A5102713002- Platelet Disorders and Treatments
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Acute Myeloid Leukemia Research
- Blood groups and transfusion
- Cancer Genomics and Diagnostics
- Cell Adhesion Molecules Research
- Retinoids in leukemia and cellular processes
- Blood Pressure and Hypertension Studies
- Hematopoietic Stem Cell Transplantation
- Monoclonal and Polyclonal Antibodies Research
- Autoimmune Bullous Skin Diseases
- Blood disorders and treatments
- Blood properties and coagulation
- Acute Lymphoblastic Leukemia research
- TGF-β signaling in diseases
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Immune Cell Function and Interaction
- Diabetes Treatment and Management
- Renal Diseases and Glomerulopathies
- Ubiquitin and proteasome pathways
- Immune cells in cancer
- Diabetes Management and Research
- Chronic Lymphocytic Leukemia Research
Stanford University
2023-2025
Geriatric Research Education and Clinical Center
2023-2024
The University of Texas MD Anderson Cancer Center
2011-2024
VA Palo Alto Health Care System
2024
University of Toronto
2012-2023
St. Michael's Hospital
2012-2023
Canadian Blood Services
2018-2023
Kirin (United States)
2021
Unity Health Toronto
2020
Kunming Medical University
2018
Abstract Immune thrombocytopenia (ITP) is a common bleeding disorder caused primarily by autoantibodies against platelet GPIIbIIIa and/or the GPIb complex. Current theory suggests that antibody-mediated destruction occurs in spleen, via macrophages through Fc–FcγR interactions. However, we and others have demonstrated anti-GPIbα (but not GPIIbIIIa)-mediated ITP often refractory to therapies targeting FcγR pathways. Here, generate mouse anti-mouse monoclonal antibodies (mAbs) recognize GPIbα...
Platelets are small anucleate cells circulating in the blood. It has been recognized for more than 100 years that platelet adhesion and aggregation at site of vascular injury critical events hemostasis thrombosis; however, recent studies demonstrated that, addition to these classic roles, platelets also have important functions inflammation immune response. contain many proinflammatory molecules cytokines (e.g., P-selectin, CD40L, IL-1β, etc.), which support leukocyte trafficking, modulate...
Osteoporosis (OP) is a serious health problem that contributes to osteoporotic structural damage and bone fragility. MicroRNAs (miRNAs) can exert important functions over endocrinology. Therefore, it of substantial significance clarify the expression function miRNAs in endocrine physiology pathology improve potential therapeutic value for metabolism-related diseases. We explored effect microRNA-182-5p (miR-182-5p) on osteoblast proliferation differentiation OP rats after alendronate (ALN)...
Platelets are small, versatile blood cells that critical for hemostasis/thrombosis. Local platelet accumulation is a known contributor to proinflammation in various disease states. However, the anti-inflammatory/immunosuppressive potential of platelets has been poorly explored. Here, we uncovered, unexpectedly, desialylated (dPLTs) down-regulated immune responses against both platelet-associated and -independent antigen challenges. Utilizing multispectral photoacoustic tomography, tracked...
Istradefylline is a selective adenosine A2A receptor antagonist for the treatment of patients with Parkinson's disease (PD) experiencing OFF episodes while on levodopa/decarboxylase inhibitor.This pooled analysis eight randomized, placebo-controlled, double-blind phase 2b/3 studies evaluated efficacy and safety istradefylline.Istradefylline was in PD receiving levodopa carbidopa/benserazide motor fluctuations. Eight 12- or 16-week trials were conducted (n = 3,245); four these basis...
This study aimed to investigate the mechanism by which microRNA-206 (miR-206) affects proliferation, apoptosis, migration and invasion of osteosarcoma (OS) cells targeting ANXA2 via AKT signaling pathway.A total 132 OS tissues 120 osteochondroma were examined in this study. The relationship between miR-206 was verified with a dual-luciferase reporter assay. expression ANXA2, AKT, PARP, FASN, Survivin, Bax, Mcl-1 Bcl-1 mRNA protein above two groups qRT-PCR western blotting. cultured divided...
Identification of circulating tumor DNA (ctDNA) following curative intent therapies is a surrogate for microscopic residual disease patients with metastatic colorectal cancer (mCRC). Preclinically, in micrometastatic microsatellite stable (MSS) cancer, increased TGFβ signaling results exclusion antitumor cytotoxic T cells from the microenvironment. Bintrafusp alfa (BA) bifunctional fusion protein composed extracellular domain TGFβRII receptor (“TGFβ trap”) and anti-PD-L1 antibody. Patients...
Importance It is unclear whether the effects of intensive vs standard blood pressure (BP) targets seen in clinical trials generalize to patients with chronic kidney disease (CKD) encountered everyday practice due differences distribution cardiovascular risk factors and coexisting conditions. Objective To evaluate beneficial adverse BP control observed Systolic Blood Pressure Intervention Trial (SPRINT) are transportable a target population adults CKD practice. Design, Setting, Participants...
Nucleophosmin (NPM) is a multifunctional protein frequently overexpressed in actively proliferating cells. Strong evidence indicates that NPM required for embryonic development and genomic stability. Here we report enhances the proliferative potential of hematopoietic stem cells (HSCs) increases their survival upon stress challenge. Both short term liquid culture clonogenic progenitor cell assays show selective expansion NPM-overexpressing HSCs. Interestingly, HSCs infected with retrovirus...
Platelets play critical roles in hemostasis and thrombosis. Emerging evidence indicates that they are versatile cells also involved many other physiological processes disease states. Fetal neonatal alloimmune thrombocytopenia (FNAIT) is a life threatening bleeding disorder caused by fetal platelet destruction maternal alloantibodies developed during pregnancy. Gene polymorphisms cause surface protein incompatibilities between mother fetus, ultimately lead to alloimmunization. FNAIT the most...
Transcriptional mechanisms governing hematopoietic stem cell (HSC) quiescence, self-renewal, and differentiation are not fully understood. Sequence-specific ssDNA-binding protein 2 (SSBP2) is a candidate acute myelogenous leukemia (AML) suppressor gene located at chromosome 5q14. SSBP2 binds the transcriptional adaptor Lim domain-binding 1 (LDB1) enhances LDB1 stability to regulate expression. Notably, Ldb1 essential for HSC specification during early development maintenance in adults. We...
Promyelocytic leukemia nuclear bodies (PML NBs) are comprised of PML and a striking variety its associated proteins. Various cellular functions have been attributed to NBs, including the regulation gene expression. We report here that induced expression recruits Sp1 into leading reduction transactivation function. Specifically, Chromatin immunoprecipitation (ChIP) assay demonstrated significantly diminishes amount binding target promoter, immunofluorescence staining showed dramatic increase...