A5033365657- Multiple Sclerosis Research Studies
- Neuroscience and Neuropharmacology Research
- Peripheral Neuropathies and Disorders
- Memory and Neural Mechanisms
- Polyomavirus and related diseases
- Stress Responses and Cortisol
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Cellular transport and secretion
- Alzheimer's disease research and treatments
- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Systemic Sclerosis and Related Diseases
- Circadian rhythm and melatonin
- Autoimmune and Inflammatory Disorders Research
- Biochemical effects in animals
- Virology and Viral Diseases
- Retinal Development and Disorders
- Hypothalamic control of reproductive hormones
- Vestibular and auditory disorders
- Long-Term Effects of COVID-19
- Acute Lymphoblastic Leukemia research
- Neuroendocrine regulation and behavior
- Ocular Diseases and Behçet’s Syndrome
- Metabolism and Genetic Disorders
Fernando Pessoa University
2016-2025
Sana'a University
2025
Hospital de São João
2015-2024
Universidade do Porto
2006-2024
Alfred Health
2021-2024
Monash University
2021-2024
The Royal Melbourne Hospital
2024
Box Hill Hospital
2024
Eastern Health
2024
National Hospital for Neurology and Neurosurgery
2024
In Multiple Sclerosis (MS) prevalence studies of community and clinical samples, indicate that 45–60% patients are cognitively impaired. These cognitive dysfunctions have been traditionally described as heterogeneous, but more recent suggest there is a specific pattern MS-related dysfunctions. With the advent disease-modifying medications for MS emphasis on early intervention treatment, detection impairment at its earliest stage becomes particularly important. this review authors address:...
Observations were made with the electron microscope on biopsies from frontal cerebral cortex of four patients showing clinical symptoms advanced Alzheimer's disease (AD). Sections all showed neuronal dendrites, and to a lesser extent, perikarya, packed paired helical filaments (PHFs) correlated complete loss normal content microtubules. It was usually impossible visualize beginning end PHF since it passed out plane section. However, not infrequently, PHFs could be seen apparently arising at...
To investigate pregnancy-related disease activity in a contemporary multiple sclerosis (MS) cohort.Using data from the MSBase Registry, we included pregnancies conceived after 31 Dec 2010 women with relapsing-remitting MS or clinically isolated syndrome. Predictors of intrapartum relapse, and postpartum relapse disability progression were determined by clustered logistic regression Cox analyses.We 1998 1619 MS. Preconception annualized rate (ARR) was 0.29 (95% CI 0.27-0.32), fell to 0.19...
Importance Ocrelizumab, a humanized monoclonal antibody targeted against CD20+ B cells, reduces the frequency of relapses by 46% and disability worsening 40% compared with interferon beta 1a in relapsing-remitting multiple sclerosis (MS). Rituximab, chimeric anti-CD20 agent, is often prescribed as an off-label alternative to ocrelizumab. Objective To evaluate whether effectiveness rituximab noninferior ocrelizumab MS. Design, Setting, Participants This was observational cohort study...
Anti-CD20 monoclonal antibodies are a class of immunosuppressive drugs widely used in the treatment central nervous system (CNS) inflammatory diseases, with well-established efficacy and safety. Although rare, these therapies can be associated serious adverse events including hematological infectious complications. This study aims to evaluate their safety tolerability profile real-world clinical practice. We conducted retrospective cohort comprising patients diagnosed multiple sclerosis (MS)...
In relapsing-remitting multiple sclerosis (RRMS), extended exposure to high-efficacy disease modifying therapy may increase the risk of side effects, compromise treatment adherence, and inflate medical costs. Treatment de-escalation, here defined as a switch lower efficacy therapy, is often considered by patients physicians, but evidence guide such decisions scarce. this study, we aimed compare clinical outcomes between who de-escalated versus those continued their therapy. retrospective...
Thyroid hormone deficiency has long been considered to affect profoundly such cognitive functions as learning and memory, which are known depend on the structural integrity of hippocampal formation. Since we previously found that number granule cells dentate gyrus is reduced in hypothyroid animals, decided extend our observations pyramidal hippocampus order gain further insight into effects hypothyroidism upon other neuronal links trisynaptic circuitry, inasmuch CA1 neurons be particularly...
Abstract The circadian rhythms displayed by numerous biological functions are known to be sex specific and affected aging. It has not been settled yet whether the sex‐ age‐related characteristics of derive from changes in anatomy suprachiasmatic nucleus. To shed light on these issues, we applied unbiased stereological techniques estimate volume nucleus as well total number its cells mean their somata nuclei progressively older groups male female Wistar rats (aged 1, 6, 12, 18, 24, 30...
Background: Time matters in multiple sclerosis (MS). Irreversible neural damage and cell loss occur from disease onset. The MS community has endorsed a management strategy of prompt diagnosis, timely intervention regular proactive monitoring treatment effectiveness activity to improve outcomes people with MS. Objectives: We sought develop internationally applicable quality standards for timely, brain health–focused care. Methods: A panel specialist neurologists participated an iterative,...
To determine the predictive value of social support on health related quality life (HRQoL) in multiple sclerosis (MS) patients.The sample is composed by 150 MS consecutive patients. We used Medical Outcomes Study Social Support Survey to assess and Health Status Questionnaire HRQoL. For inferential analysis, we Multiple Linear Regression with stepwise selection variables.The age, basic education, psychological disability explains 41.6% variance physical function, 29.4% performance 30.6%...
Autologous hematopoietic stem cell transplant (AHSCT) is available for treatment of highly active multiple sclerosis (MS).
Importance Natalizumab cessation is associated with a risk of rebound disease activity. It important to identify the optimal switch disease-modifying therapy strategy after natalizumab limit severe relapses. Objectives To compare effectiveness and persistence dimethyl fumarate, fingolimod, ocrelizumab among patients relapsing-remitting multiple sclerosis (RRMS) who discontinued natalizumab. Design, Setting, Participants In this observational cohort study, patient data were collected from...
Sickle cell anemia (SCA) is recognized globally, but little known about affected Hispanic populations. In partnership with Dominican Republic, a Caribbean Island large SCA population, TCD screening program provided hydroxyurea to children conditional velocities. Building local capacity, ten medical graduates were certified in examinations and trained management. Stroke Avoidance for Children REpública Dominicana trial (SACRED, NCT02769845) enrolled 283 average age 8.7±3.4 years 130 (46%)...
Abstract The effects of hypothyroidism upon the structure central nervous system adult rats are poorly understood in spite evidence that mature brain is vulnerable to this condition. Existing developmental studies show morphological changes induced by thyroid hormone deficiency related alterations neurogenesis. We studied granular layer dentate gyrus under different experimental conditions hypothyroidism, because rodents neurogenesis granule cells continues during adulthood. following groups...
There is evidence that chronic ethanol treatment (CET) disrupts the biological rhythms of various brain functions and behaviors. Because suprachiasmatic nucleus (SCN) widely recognized as dominant pacemaker circadian system, we have examined effects CET withdrawal on main morphological features chemoarchitecture this hypothalamic nucleus. Groups rats ethanol-treated for 6 12 months were compared with withdrawn (ethanol-treated then switched to a normal diet an additional months) groups...
Exposure of rats to sustained stress has been associated with behavioural impairments, the degree impairment being greater increasing age subject. Although deficits have frequently attributed stress-induced neuronal loss in hippocampus, validity that view may be disputed since it is based on data collected using conventional morphometric methods which are subject bias. The question whether per se does indeed induce hippocampal cell losses was therefore re-examined unbiased stereological...