A5062775755- Multiple Sclerosis Research Studies
- Advanced Neuroimaging Techniques and Applications
- Peripheral Neuropathies and Disorders
- Advanced MRI Techniques and Applications
- Systemic Lupus Erythematosus Research
- Polyomavirus and related diseases
- Functional Brain Connectivity Studies
- SARS-CoV-2 and COVID-19 Research
- Ultrasound and Hyperthermia Applications
- Long-Term Effects of COVID-19
- Rheumatoid Arthritis Research and Therapies
- Bone and Joint Diseases
- RNA regulation and disease
- Systemic Sclerosis and Related Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- MRI in cancer diagnosis
- Traumatic Brain Injury Research
- Neurogenesis and neuroplasticity mechanisms
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Autoimmune and Inflammatory Disorders Research
- Sphingolipid Metabolism and Signaling
- Neural dynamics and brain function
- Ultrasound Imaging and Elastography
- Neuroinflammation and Neurodegeneration Mechanisms
- Viral Infections and Immunology Research
Ospedale Policlinico San Martino
2017-2025
University of Genoa
2016-2025
University of Rome Tor Vergata
2025
Imperial College London
2025
John Wiley & Sons (United States)
2024
Hudson Institute
2024
Mount Sinai Hospital
2014-2023
University of Siena
2019-2023
Icahn School of Medicine at Mount Sinai
2013-2022
Mario Negri Institute for Pharmacological Research
2022
Accurate clinical course descriptions (phenotypes) of multiple sclerosis (MS) are important for communication, prognostication, design and recruitment trials, treatment decision-making. Standardized published in 1996 based on a survey international MS experts provided purely phenotypes data consensus at that time, but imaging biological correlates were lacking. Increased understanding its pathology, coupled with general concern the original descriptors may not adequately reflect more...
Object. Diffuse axonal injury (DAI) is a major complication of traumatic brain (TBI) that leads to functional and psychological deficits. Although DAI frequently underdiagnosed by conventional imaging modalities, it can be demonstrated using diffusion tensor imaging. The aim this study was assess the presence extent in patients with mild TBI. Methods. Forty-six TBI 29 healthy volunteers underwent magnetic resonance (MR) protocol including: dual—spin echo, fluid-attenuated inversion recovery,...
<b><i>Objectives:</i></b> To quantify, using diffusion tensor imaging (DTI), the tissue damage in lesions and normal-appearing white matter (NAWM) from a large cohort of patients with MS to investigate magnitude correlation between DTI-derived metrics clinical disability. <b><i>Methods:</i></b> Dual-echo DTI scans were obtained 78 relapsing-remitting, secondary progressive, or primary progressive 20 normal control participants. Post-contrast T1-weighted images also patients. After creating...
To report the 5-year risk and to identify factors for development of a seminal acute or progressive clinical event in multi-national cohort asymptomatic subjects meeting 2009 RIS Criteria.Retrospectively identified from 22 databases within 5 countries were evaluated. Time first related demyelination (acute 12-month progression neurological deficits) was compared across different groups by univariate multivariate analyses utilizing Cox regression model.Data available 451 (F: 354 (78.5%)). The...
Significance Depressive and manic phases in bipolar disorder show opposite constellations of affective, cognitive, psychomotor symptoms. These may be related to disbalance between large-scale networks, such as the default-mode (DMN) sensorimotor network (SMN) that are involved these functions. The variability resting-state signal amplitude—an index neuronal activity—of networks their balances was investigated disorder. DMN/SMN balance tilted toward DMN depression (characterized by excessive...
Conventional imaging is unable to detect damage that accounts for permanent cognitive impairment in patients with mild traumatic brain injury (mTBI). While diffusion tensor (DTI) can help diffuse axonal (DAI), it a limited indicator of tissue complexity. It has also been suggested the thalamus may play an important role development clinical sequelae mTBI. The purpose this study was determine if diffusional kurtosis (DKI), novel quantitative magnetic resonance (MRI) technique, provide early...
In patients with Multiple Sclerosis (pwMS) disease-modifying therapies (DMTs) affects immune response to antigens. Therefore, post-vaccination serological assessments are needed evaluate the effect of vaccine on SARS-CoV-2 antibody response.We designed a prospective multicenter cohort study enrolling pwMS who were scheduled for SARS-Cov-2 vaccination mRNA vaccines (BNT162b2, Pfizer/BioNTech,Inc or mRNA-1273, Moderna Tx,Inc). A blood collection before first dose and 4 weeks after second was...
Acute disseminated encephalomyelitis (ADEM) is a rare autoimmune disease of the CNS that often after viral infections and mainly affecting children. ADEM characterized by onset multifocal neurologic symptoms, encephalopathy, with brain MRI showing demyelinating abnormalities in acute phase.1 Coronavirus 2019 (COVID-19) novel entity caused pandemic severe respiratory syndrome coronavirus-2 (SARS-CoV-2), which influenza-like pneumonia, cases insufficiency.2 Many complications occurring...
Coronavirus disease 19 (COVID-19) is a novel entity that spreading throughout the world. It has been speculated patients with comorbidities and elderly could be at high risk for respiratory insufficiency death. Immunosuppression expose infected to even higher risks of complications due dampened immune response. However, it overactive response drive clinical deterioration and, based on this hypothesis, several immunosuppressants are currently being tested as potential treatment COVID-19.In...
Abstract Multiple sclerosis (MS) is a chronic and progressive neurological disease that characterized by neuroinflammation, demyelination neurodegeneration occurring from the earliest phases of may be underestimated. MS patients accumulate disability through relapse-associated worsening or progression independent relapse activity. Early intervention with high-efficacy disease-modifying therapies (HE-DMTs) represent best window opportunity to delay irreversible central nervous system damage...
BackgroundIn this study we aimed to monitor the risk of breakthrough SARS-CoV-2 infection in patients with MS (pwMS) under different DMTs and identify correlates reduced protection.MethodsThis is a prospective Italian multicenter cohort study, long-term clinical follow-up CovaXiMS (Covid-19 vaccine Multiple Sclerosis) study. 1855 pwMS scheduled for mRNA vaccination were enrolled followed up mean time 10 months. The cumulative incidence Covid-19 cases was calculated before after December...
Clinical, pathological, and imaging evidence in multiple sclerosis (MS) suggests that a smoldering inflammatory activity is present from the earliest stages of disease underlies progression disability, which proceeds relentlessly independently clinical radiological relapses (PIRA). The complex system pathological events driving "chronic" worsening likely linked with early accumulation compartmentalized inflammation within central nervous as well insufficient repair phenomena mitochondrial...
Abstract Background ChatGPT is an open-source natural language processing software that replies to users’ queries. We conducted a cross-sectional study assess people living with Multiple Sclerosis’ (PwMS) preferences, satisfaction, and empathy toward two alternate responses four frequently-asked questions, one authored by group of neurologists, the other ChatGPT. Methods An online form was sent through digital communication platforms. PwMS were blind author each response asked express their...
Purpose: To determine retrospectively whether relative cerebral blood volume (CBV) measurements can be used to predict clinical response in patients with low-grade gliomas. Materials and Methods: Approval for this retrospective HIPAA-compliant study was obtained from the Institutional Board of Research Associates, waiver informed consent. Thirty-five (23 male 12 female patients; median age, 39 years; range, 4–80 years) histologically diagnosed gliomas (21 astrocytomas 14 oligodendrogliomas...
To explore whether baseline diffusion tensor imaging (DTI) metrics are predictive of cognitive functioning 6 months post-injury in patients with mild traumatic brain injury (MTBI).Seventeen MTBI and 29 sex- age-matched healthy controls were studied.Participants underwent an MRI protocol including DTI, at average 4.0 (range: 1-10) days post-injury. Mean diffusivity (MD) fractional anisotropy (FA) measured the following white matter (WM) regions: centra semiovale, genu splenium corpus callosum...
Neuro-axonal degeneration occurs progressively from the onset of multiple sclerosis and is thought to be a significant cause increasing clinical disability. Several histopathological studies experimental autoimmune encephalomyelitis have shown that accumulation sodium in axons can promote reverse action sodium/calcium exchanger that, turn, leads lethal overload intra-axonal calcium. We hypothesized magnetic resonance imaging would provide an indicator cellular metabolic integrity ion...
<h3>BACKGROUND AND PURPOSE:</h3> Cognitive impairment is frequent among patients with mild traumatic brain injury despite the absence of detectable damage on conventional MR imaging. In this study, quantitative imaging techniques DTI, DKI, and ASL were used to measure changes in structure function thalamus WM MTBI during a short follow-up period, determine whether these can be investigate relationships cognitive performance predict outcome. <h3>MATERIALS METHODS:</h3> Twenty 16 controls...