Giampaolo Brichetto
A5016510324- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Stroke Rehabilitation and Recovery
- Cerebral Palsy and Movement Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Effects of Vibration on Health
- Systemic Sclerosis and Related Diseases
- Autoimmune and Inflammatory Disorders Research
- Balance, Gait, and Falls Prevention
- Rheumatoid Arthritis Research and Therapies
- Long-Term Effects of COVID-19
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Motor Control and Adaptation
- SARS-CoV-2 and COVID-19 Research
- Vestibular and auditory disorders
- Mycobacterium research and diagnosis
- Amyotrophic Lateral Sclerosis Research
- Genetic Neurodegenerative Diseases
- Polyomavirus and related diseases
- Wireless Body Area Networks
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Family Support in Illness
- Action Observation and Synchronization
- Herpesvirus Infections and Treatments
Associazione Italiana Sclerosi Multipla
2016-2025
Multiple Sclerosis Foundation
2015-2024
Multiple Sclerosis Society
2020-2024
Vita-Salute San Raffaele University
2024
University of Genoa
2001-2022
Mario Negri Institute for Pharmacological Research
2022
Istituti di Ricovero e Cura a Carattere Scientifico
2022
King's College London
2021-2022
Multiple Sclerosis International Federation
2018
BackgroundIn this study we aimed to monitor the risk of breakthrough SARS-CoV-2 infection in patients with MS (pwMS) under different DMTs and identify correlates reduced protection.MethodsThis is a prospective Italian multicenter cohort study, long-term clinical follow-up CovaXiMS (Covid-19 vaccine Multiple Sclerosis) study. 1855 pwMS scheduled for mRNA vaccination were enrolled followed up mean time 10 months. The cumulative incidence Covid-19 cases was calculated before after December...
In a multicenter cross-sectional study, the authors assessed pain in patients with multiple sclerosis (MS) using symptom-oriented approach. Out of 2,077 questionnaires, we used 1,672 for data analysis. Pain and frequencies included trigeminal neuralgia 2%, Lhermitte’s sign 9%, dysesthetic 18.1%, back 16.4%, painful tonic spasms 11%. Comparison between different groups showed significant differences age, Expanded Disability Status Scale, disease duration, course, but not sex. This study...
Improvement of sensory strategies is a relevant part balance rehabilitation in multiple sclerosis (MS). This study aimed to Assess the effectiveness visual-feedback exercises improving MS. We divided 36 patients into Wii and control-treated groups that underwent rehabilitation. Outcomes were obtained for Berg Balance Scale (BBS), Modified Fatigue Impact Scale, sway area under conditions opened closed eyes. BBS showed statistically significant improvement (from 49.6 54.6 points, p < 0.05)...
Despite recent advances in multiple sclerosis (MS) care, many patients only infrequently access health care services, or are unable to them easily, for reasons such as mobility restrictions, travel costs, consultation and treatment time constraints, a lack of locally available MS expert services. Advances mobile communications have led the introduction electronic (eHealth) technologies, which helping improve both quality As Internet is now readily accessible through smart devices, most...
It is unclear how multiple sclerosis (MS) affects the severity of COVID-19. The aim this study to compare COVID-19-related outcomes collected in an Italian cohort patients with MS expected age- and sex-matched population.Hospitalization, intensive care unit (ICU) admission, death after COVID-19 diagnosis 1,362 were compared population a retrospective observational case-cohort population-based control. observed vs events whole different subgroups (higher risk: Expanded Disability Status Scale...
Upper limb impairments can occur in patients with multiple sclerosis, affecting daily living activities; however there is at present no definite agreement on the best rehabilitation treatment strategy to pursue. Moreover, motor training has been shown induce changes white matter architecture healthy subjects. This study aimed evaluating behavioral and microstructural following a 2-month upper based task-oriented exercises sclerosis. Thirty (18 females 12 males; age = 43.3 ± 8.7 years) stable...
Cognitive impairment is common in people with neurological diseases and severely affects their social professional life. It has been shown that intensive personalized cognitive rehabilitation (CR), based on working memory exercises, leads to improved status of healthy cognitive-impaired subjects. New technologies would help promote accessible, at-home, self-managed CR interventions.The aim this paper describe the design Training Kit (COGNI-TRAcK), an app for mobile devices, self-administer...
Cognitive impairment is common in multiple sclerosis (MS), but the definition of best cognitive rehabilitation tools and features still an open issue among researchers. The aims present study were to evaluate effectiveness COGNI-TRAcK (a customized application software delivering personalized working memory-based exercises) on cognitively impaired people with MS investigate effects adaptive vs. a non-adaptive training administered by means COGNI-TRAcK.Twenty eight patients (20 women, age...
COVID-19 pandemic is creating collateral damage to persons with disabling conditions of different aetiology. The restrictions imposed contain the spread infection limiting access many health services, including rehabilitation. It expected that such situation will lead long lasting negative consequences for disability, increasing functional limitations in chronic and hindering recovery after acute events. aim this paper explore impact on people reporting contents sixth Italian Society...
The MuSC-19 project is an Italian cohort study open to international partners that collects data on multiple sclerosis (MS) patients with COVID-19. During the second wave of pandemic, serological tests became routinely available.To evaluate seroprevalence anti-SARS-CoV-2 antibodies according use disease-modifying therapy (DMT) in a subset included set who had undergone test.We evaluated association between positive test results and time elapsed since infection onset, age, sex, Expanded...
Availability of new disease-modifying therapies (DMTs) and changes therapeutic paradigms have led to a general improvement multiple sclerosis (MS) prognosis in adults. It is still unclear whether this also involves patients with pediatric-onset MS (POMS), whose early management more challenging.To evaluate the POMS over time association managing standards.Retrospective, multicenter, observational study. Data were extracted collected May 2019 from Italian Registry, digital database including...
Significant advancements have been achieved in delineating the progress of Global PROMS (PROMS) Initiative. The Initiative, a collaborative endeavor by European Charcot Foundation and Multiple Sclerosis International Federation, strives to amplify influence patient input on MS care establish cohesive perspective Patient-Reported Outcomes (PROs) for diverse stakeholders. This initiative has established an expansive, participatory governance framework launching four dedicated working groups...
Cerebellar symptoms are extremely disabling and common in Multiple Sclerosis (MS) subjects. In this feasibility study, we developed tested a robot therapy protocol, aimed at the rehabilitation of incoordination MS Eight subjects with clinically defined performed planar reaching movements while grasping handle robotic manipulandum, which generated forces that either reduced (error-reducing, ER) or enhanced (error-enhancing, EE) curvature their movements, assessed beginning each session. The...
Objective To describe the disruptions in care experienced by persons with Multiple Sclerosis Italy due to COVID-19 pandemic and self-reported impact on their health wellbeing. Methods A cross-sectional online survey was completed 2722 Sclerosis, after instituted a national lockdown response pandemic. Results Persons reported that caused broad usual social services, which impacted Disruptions were consistently associated negative impacts expected progression of disease, out-of-pocket...
The aim was to compare the effectiveness of dual-task training (DTT) compared single mobility (SMT) on walking, and cognition, in persons with Multiple Sclerosis (pwMS). Forty pwMS were randomly assigned DTT or SMT groups. DTT-group performed exercises using an interactive tablet-based application, while SMT-group received conventional walking balance exercises. Both interventions supervised identical weeks (8) sessions (20). Nine cognitive-motor conditions assessed at baseline, after...
Abstract Background Cognitive dysfunction affects up to 70% of people with progressive MS (PMS). It can exert a deleterious effect on activities daily living, employment and relationships. Preliminary evidence suggests that performance improve cognitive rehabilitation (CR) aerobic exercise (EX), but existing data are predominantly from relapsing-remitting without impairment. There is therefore need investigate whether this also the case in forms disease who have objectively identified...
Background: Altered integration of signals from visual (VIS), somatosensory (PROP) and vestibular system (VEST) lead to balance control impairments affecting the daily living activities patients with multiple sclerosis (PwMS). As a consequence, tailored interventions could be crucial in improving efficacy rehabilitation treatments. Objective: The objective this paper is assess treatments for disorders based on visual, deficits versus traditional exercises. Methods: Thirty-two PwMS were...