A5050976625- Neuroscience and Neuropharmacology Research
- Multiple Sclerosis Research Studies
- Ion channel regulation and function
- Neuroscience and Neural Engineering
- SARS-CoV-2 and COVID-19 Research
- Neurobiology and Insect Physiology Research
- Pharmacological Receptor Mechanisms and Effects
- Metabolomics and Mass Spectrometry Studies
- Chemical Synthesis and Analysis
- Bioinformatics and Genomic Networks
- Lipid Membrane Structure and Behavior
- Health Systems, Economic Evaluations, Quality of Life
- Computational Drug Discovery Methods
- Electrochemical Analysis and Applications
- Photoreceptor and optogenetics research
- Nicotinic Acetylcholine Receptors Study
- Molecular Sensors and Ion Detection
- Phenothiazines and Benzothiazines Synthesis and Activities
- Mental Health and Patient Involvement
- Long-Term Effects of COVID-19
- Autoimmune and Inflammatory Disorders Research
- Polyomavirus and related diseases
- Ethics in Clinical Research
- Mindfulness and Compassion Interventions
- Genetics, Bioinformatics, and Biomedical Research
Optimal Solutions (United States)
2025
Accelerated Cure Project for Multiple Sclerosis
2013-2024
South Texas Accelerated Research Therapeutics
2024
Research Network (United States)
2020-2022
The University of Melbourne
2021-2022
University of Tasmania
2021-2022
University of Technology Sydney
2021
KU Leuven
2021
Mammoth Hospital
2021
International AIDS Vaccine Initiative
2021
<h3>Background and Objectives</h3> People with multiple sclerosis (MS) are a vulnerable group for severe coronavirus disease 2019 (COVID-19), particularly those taking immunosuppressive disease-modifying therapies (DMTs). We examined the characteristics of COVID-19 severity in an international sample people MS. <h3>Methods</h3> Data from 12 data sources 28 countries were aggregated (sources could include patients 1–12 countries). Demographic (age, sex), clinical (MS phenotype, disability),...
Systems biology has developed in recent years from a technology-driven enterprise to new strategic tool Life Sciences, particularly for innovative drug discovery and development. Combining the ultimate systems phenotyping with in-depth investigations of biomolecular mechanisms will enable revolution our understanding disease pathology advance translational medicine, combination therapies, integrative personalized medicine. A prerequisite deriving benefits such approach is reliable...
1. Miniature end-plate currents were recorded at neuromuscular junctions of toads, either in voltage-clamped fibres or with extracellular electrodes. The two methods gave similar results. 2. Two types m.e.p.c.s, differing their growth times (50-300 musec and 0-5-5 msec) found. more frequent had the shorter times. 3. decay m.e.p.c.s was exponential a single time constant. constant an function membrane potential, becoming less as depolarized. In contrast, there little change, some cases...
1. The post-synaptic effects of the aliphatic alcohols, ethanol to hexanol, were investigated at neuromuscular junctions toads, with particular emphasis on ethanol. 2. alcohols increased amplitude and duration miniature end-plate potentials. It is shown that this effect was due prolongation decay phase currents (m.e.p.c.s). There no growth m.e.p.c.s. 3. prolonged m.e.p.c.s in remained exponential normally sensitive membrane potential. Prolonged associated an equivalent mean elementary...
<h3>Objective</h3> To develop a valid algorithm for identifying multiple sclerosis (MS) cases in administrative health claims (AHC) datasets. <h3>Methods</h3> We used 4 AHC datasets from the Veterans Administration (VA), Kaiser Permanente Southern California (KPSC), Manitoba (Canada), and Saskatchewan (Canada). In VA, KPSC, Manitoba, we tested performance of candidate algorithms based on inpatient, outpatient, disease-modifying therapy (DMT) compared to medical records review using...
Certain demographic and clinical characteristics, including the use of some disease-modifying therapies (DMTs), are associated with severe acute respiratory syndrome coronavirus 2 infection severity in people multiple sclerosis (MS). Comprehensive exploration these relationships large international samples is needed.Clinician-reported demographic/clinical data from 27 countries were aggregated into a set 5,648 patients suspected/confirmed disease 2019 (COVID-19). COVID-19 outcomes...
We employed diffusion-weighted MRI (DWI) to identify regions of focal brain ischemia during the first 3 hours after permanent occlusion middle cerebral artery in rats. Using DWI as early 30 minutes onset ischemia, it was possible areas destined progress infarction over next 24 untreated animals, demonstrated by postmortem evaluation. studies revealed cerebroprotective effects a noncompetitive N-methyl-D-aspartate receptor antagonist, CNS 1102, administered 15 postocclusion, both on cortical...
The anticonvulsant barbiturate phenobarbitone increases membrane current and conductance responses to γ-aminobutyric acid (GABA) in cultured mouse spinal neurons. Analyses of GABA fluctuations under control conditions the presence show that principle action is increase average time during which GABA- activated channels remain open. duration miniature synaptic currents with a constant decay similar mean open-time GABA-activated prolonged by drug. results suggest (1) events are GABA-mediated...
People with multiple sclerosis (PwMS) experienced changes in health behaviors and access to MS care due the COVID-19 pandemic. The USA has highest recognized number of Covid19 infections globally. extent impact not been well characterized large samples PwMS date. patient perspective on would complement physician-reported cases literature.
Background: We need high-quality data to assess the determinants for COVID-19 severity in people with MS (PwMS). Several studies have recently emerged but there is great benefit aligning collection efforts at a global scale. Objectives: Our mission scale-up and provide community data-driven insights as soon possible. Methods: Numerous stakeholders were brought together. Small dedicated interdisciplinary task forces created speed-up formulation of study design work plan. First step was agree...
Significant advancements have been achieved in delineating the progress of Global PROMS (PROMS) Initiative. The Initiative, a collaborative endeavor by European Charcot Foundation and Multiple Sclerosis International Federation, strives to amplify influence patient input on MS care establish cohesive perspective Patient-Reported Outcomes (PROs) for diverse stakeholders. This initiative has established an expansive, participatory governance framework launching four dedicated working groups...
1. Intracellular recordings using the voltage‐clamp technique were made at room temperature (24 +/‐ 1.5 degrees C) from mouse spinal and sensory neurones growing in dissociated cell culture. 2. Membrane current responses could be elicited by ionophoresis of neutral amino acids, gamma‐aminobutyric acid (GABA), beta‐alanine (BALA) glycine to body processes these neurones. 3. All membrane associated with increases fluctuations. Most analysis presented here was applied generated body. 4. Many...
Abstract Background Data generated using 'omics' technologies are characterized by high dimensionality, where the number of features measured per subject vastly exceeds subjects in study. In this paper, we consider issues relevant design biomedical studies which goal is discovery a subset and an associated algorithm that can predict binary outcome, such as disease status. We compare performance four commonly used classifiers (K-Nearest Neighbors, Prediction Analysis for Microarrays, Random...
A two‐microelectrode voltage‐clamp technique was used to record membrane current responses induced by the application of neutral amino acids, γ‐aminobutyric acid (GABA) and glycine, mouse spinal neurones maintained in cell culture. Membrane GABA were depressed convulsant agents, bicuculline, Picrotoxin pentylenetetrazole. glycine compound, strychnine. Analysis fluctuations about mean response during prolonged applications revealed that neither conductance nor average open‐time GABA‐activated...
The Patient-Centered Outcomes Research Institute (PCORI) recently launched PCORnet to establish a single inter-operable multicenter data research network that will support observational and randomized clinical trials. This paper provides an overview of the patient-powered networks (PPRNs), patient organizations focused on particular health condition are interested in sharing information engaging research. PPRNs build their foundation trust within communities draw expertise, working with...
There are limited data on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine reactogenicity in persons with multiple sclerosis (PwMS) and how is affected by disease-modifying therapies (DMTs). The objective of this retrospective cross-sectional study was to generate real-world sclerosis-specific safety information, particularly the context specific DMTs, provide information mitigate concerns hesitant PwMS.Between 3/2021 6/2021, participants iConquerMS, an online...
1. The membrane potential of giant muscle fibres Maia squinado was measured with an intracellular wire electrode. On applying L-glutamate to the fibre cell deplorized and fluctuations around its mean level--glutamate noise--were seen. 2. variance glutamate voltage noise is proportional level depolarization. can be regarded as being caused by numerous exponentially decaying elementary events about 5 X 10(-10) V in amplitude. miniature excitatory junctional (min.e.j.p.) approximately 6000...