A5079404465- Multiple Sclerosis Research Studies
- Autoimmune and Inflammatory Disorders Research
- Genetics and Neurodevelopmental Disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- COVID-19 and Mental Health
- Autism Spectrum Disorder Research
- Powdery Mildew Fungal Diseases
- Retinal Development and Disorders
- SARS-CoV-2 and COVID-19 Research
- Polyomavirus and related diseases
- Health Systems, Economic Evaluations, Quality of Life
- T-cell and Retrovirus Studies
- Olfactory and Sensory Function Studies
- Family Support in Illness
- Neuroscience and Neuropharmacology Research
- Family and Disability Support Research
- Epigenetics and DNA Methylation
- Psoriasis: Treatment and Pathogenesis
- Digital Mental Health Interventions
- Parkinson's Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Photoreceptor and optogenetics research
- Retinal Diseases and Treatments
- Amyotrophic Lateral Sclerosis Research
- Mycobacterium research and diagnosis
The University of Melbourne
2013-2024
Sinai Hospital
2024
University of Tasmania
2021-2022
University of Technology Sydney
2021
KU Leuven
2021
University of the Punjab
2019
Monash University
2012-2018
The Alfred Hospital
2012-2018
Australian Regenerative Medicine Institute
2012
Indraprastha Apollo Hospitals
2012
<h3>Background and Objectives</h3> People with multiple sclerosis (MS) are a vulnerable group for severe coronavirus disease 2019 (COVID-19), particularly those taking immunosuppressive disease-modifying therapies (DMTs). We examined the characteristics of COVID-19 severity in an international sample people MS. <h3>Methods</h3> Data from 12 data sources 28 countries were aggregated (sources could include patients 1–12 countries). Demographic (age, sex), clinical (MS phenotype, disability),...
Certain demographic and clinical characteristics, including the use of some disease-modifying therapies (DMTs), are associated with severe acute respiratory syndrome coronavirus 2 infection severity in people multiple sclerosis (MS). Comprehensive exploration these relationships large international samples is needed.Clinician-reported demographic/clinical data from 27 countries were aggregated into a set 5,648 patients suspected/confirmed disease 2019 (COVID-19). COVID-19 outcomes...
Abstract Background People with multiple sclerosis (MS) are a vulnerable group for severe COVID-19, particularly those taking immunosuppressive disease-modifying therapies (DMTs). We examined the characteristics of COVID-19 severity in an international sample people MS. Methods Data from 12 data-sources 28 countries were aggregated. Demographic and clinical covariates queried, alongside outcomes, hospitalisation, admission to ICU, requiring artificial ventilation, death. Characteristics...
Modifiable lifestyle factors are important to aid people with multiple sclerosis in the self-management of their disease. Current programs limited by face-to-face mode delivery but there is immense potential internet deliver these effectively.The aims this study assess feasibility a digitalized educational program for MS.In randomized controlled trial, MS were randomly allocated participate 6-week tailored web-based or generic standard-care course, and blinded allocation. Participants...
Modifiable lifestyle factors, including diet, have been implicated in multiple sclerosis (MS) progression, but prospective evidence is limited. The aim of this study was to examine relationships between quality diet and subsequent disability over 7.5 years an international cohort people living with MS (pwMS).Data from 602 participants the HOLISM (Health Outcomes Lifestyle In a Sample Multiple sclerosis) were analysed. Quality assessed using modified Diet Habits Questionnaire (DHQ)....
We have used a transgenic approach to visualize functionally activated neurons and their projections. The mice contain tau-lacZ fusion gene regulated by the promoter for c -fos , an immediate early that is rapidly induced in after functional stimulation. Constitutive expression of β-galactosidase (β-gal), lacZ product, was low accord with previous reports c- fos expression. However, β-gal positive clearly cell bodies, axons, dendrites. Treatment kainic acid, strong inducer expression,...
Rett syndrome (RTT), the second leading cause of mental retardation in girls, is caused by mutations X-linked gene for methyl-CpG-binding protein 2 (MeCP2), a transcriptional repressor. In addition to well-documented neuroanatomical and behavioral deficits, RTT characterized reduced markers cholinergic activity general neuronal health. Previously, we have shown that early postnatal choline (Cho) supplementation improves symptoms mouse model (Mecp2(1lox) mice). this study, use NMR...
Objectives To establish a Prostate Cancer Outcomes Registry‐Australia and New Zealand ( PCOR ‐ ANZ ) for monitoring outcomes of prostate cancer treatment care, in cost‐effective manner. Materials Methods Stakeholders were recruited based on their interest, importance achieving the reporting clinical practice patient outcomes, amalgamation existing registries. Each participating jurisdiction is responsible local governance, site recruitment, data collection, transfer into . each registry,...
Abstract Background and purpose Modifiable lifestyle factors, including diet, may affect clinical outcomes in multiple sclerosis (MS). This study assessed the relationships between disability, fatigue, depression risk people with MS. Methods Participants from Health Outcomes Lifestyle In a Sample of Multiple (HOLISM) international cohort were over 2.5 years. Dietary data obtained using modified Diet Habits Questionnaire (DHQ), disability calculated Patient‐determined MS Severity Score...
Increasingly, dietary improvements have been shown to positive associations with health outcomes in people multiple sclerosis (pwMS). However, adhering a MS-specific or high-quality diet may be challenge. We therefore assessed the level of diet-adherence necessary improve depression, fatigue, and disability.Data from an international population pwMS followed over 7.5 years (n = 671) were analyzed. Self-reported quality via habits questionnaire (DHQ), adherence six MS-diets [Ashton Embry Best...
People with multiple sclerosis (pwMS) report reduced quality of life (QoL). Engagement healthy lifestyle behaviours, including consuming a diet, regular physical activity, and adequate vitamin D exposure, is associated higher QoL. We aim to assess whether individual behaviours are more beneficial QoL than others, there additive benefits by engaging in concurrently.Data from pwMS who completed an online survey at baseline, 2.5-, 5- 7.5-year follow-up, were analysed. Behaviours assessed...
Abstract Background People living with multiple sclerosis (plwMS) seek access to information on evidence-based lifestyle-related risk factors associated (MS). As the internet has made delivery of lifestyle increasingly accessible and cost-effective, we designed Multiple Sclerosis Online Course (MSOC) deliver a multimodal modification program for plwMS. Two MS online courses were developed: intervention course based recommendations Overcoming (OMS) standard-care representing standard from...
Purpose: This study explored whether the proangiogenic factor Angiotensin II (AngII) had a direct effect on activation state of microglia via type 1 receptor (AT1-R). Methods: Microglial dynamic activity was investigated in live retinal flatmounts from adult Cx3Cr1+/GFP mice under control, AngII (5 μM) or + candesartan (0.227 conditions. The effects intravitreal administration (10 mM) were also at 24 hours, with retinae processed for immunocytochemistry, flow cytometry, inflammatory...
BackgroundFatigue is among the most prevalent symptoms for people with multiple sclerosis (pwMS) and significantly detrimental to mental health-related (mental) quality of life (QoL). We examined role depression physical activity as mediators in fatigue-QoL relationship pwMS.MethodsUsing baseline cross-sectional data from an international cohort 2,104 pwMS, characteristics fatigue QoL, measured by Fatigue Severity Scale MSQOL-54 respectively, were assessed using linear log-binomial...
Fatigue and disability are indicators of disease progression experienced by many people with multiple sclerosis (pwMS). Understanding trajectories these outcomes, their predictors, may provide insight to potential interventions for MS management.
Healthy lifestyle behaviour modification may improve health outcomes in people with multiple sclerosis (pwMS), but empirical evidence is needed to confirm prior study findings. We developed an online multimodal intervention (Multiple Sclerosis Online Course) examine the impact of on pwMS via a randomized control trial (RCT). However, present specifically analyses baseline data assess engagement healthy lifestyles by RCT participants and cross-sectional associations outcomes.
Abstract Background Growing evidence suggests a role of lifestyle modification in improved health outcomes for people with multiple sclerosis (pwMS); however, perspectives pwMS who engage are lacking. Objective We explored regarding the lifestyle‐related risk factors (MS) disease management to understand attitudes and experiences as part self‐management from patient perspective. Design Participants were ≥18 years English speaking responded free‐text open‐ended question Health Outcomes...
There is increasing interest in the role of diet multiple sclerosis (MS) progression and whether a healthier may lead to improved health wellbeing people living with MS (plwMS).To assess prospective relationship quality dietary intakes life (QoL) an international cohort plwMS followed over 7.5 years.Data from Health Outcomes Lifestyle In Sample Multiple (HOLISM) baseline 7.5-year review were analysed. Quality was assessed using Diet Habits Questionnaire (DHQ). QoL measured by MSQOL-54,...