Juan Ignacio Rojas
A5042670252- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Systemic Lupus Erythematosus Research
- Systemic Sclerosis and Related Diseases
- Rheumatoid Arthritis Research and Therapies
- Polyomavirus and related diseases
- SARS-CoV-2 and COVID-19 Research
- Dementia and Cognitive Impairment Research
- Health Systems, Economic Evaluations, Quality of Life
- Viral Infections and Immunology Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Ultrasound and Hyperthermia Applications
- Autoimmune and Inflammatory Disorders Research
- Long-Term Effects of COVID-19
- Parkinson's Disease Mechanisms and Treatments
- Acute Ischemic Stroke Management
- Radiation Dose and Imaging
- Cerebrovascular and Carotid Artery Diseases
- Virology and Viral Diseases
- Acute Lymphoblastic Leukemia research
- Drilling and Well Engineering
- Hydraulic Fracturing and Reservoir Analysis
- RNA regulation and disease
- Protein Tyrosine Phosphatases
- Neuroinflammation and Neurodegeneration Mechanisms
Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno
2020-2025
Hospital Universitario Austral
2020-2025
Rush University Medical Center
2024
Novartis (Switzerland)
2024
Merck (Germany)
2024
Bayer (United States)
2024
Hospital Alemán
2024
The University of Queensland
2023
QIMR Berghofer Medical Research Institute
2023
University of Tasmania
2021-2023
<h3>Background and Objectives</h3> People with multiple sclerosis (MS) are a vulnerable group for severe coronavirus disease 2019 (COVID-19), particularly those taking immunosuppressive disease-modifying therapies (DMTs). We examined the characteristics of COVID-19 severity in an international sample people MS. <h3>Methods</h3> Data from 12 data sources 28 countries were aggregated (sources could include patients 1–12 countries). Demographic (age, sex), clinical (MS phenotype, disability),...
Certain demographic and clinical characteristics, including the use of some disease-modifying therapies (DMTs), are associated with severe acute respiratory syndrome coronavirus 2 infection severity in people multiple sclerosis (MS). Comprehensive exploration these relationships large international samples is needed.Clinician-reported demographic/clinical data from 27 countries were aggregated into a set 5,648 patients suspected/confirmed disease 2019 (COVID-19). COVID-19 outcomes...
To assess the age at menopause (AM) in Latin America urban areas.A total of 17,150 healthy women, aged 40 to 59 years, accompanying patients healthcare centers 47 cities 15 American countries, were surveyed regarding their age, educational level, coverage, history gynecological surgery, smoking habit, presence menses, and use contraception or hormone therapy menopause. The AM was calculated using logit analysis.The mean entire sample 49.4 +/- 5.5 years. Mean level 9.9 4.5 oral 22.1% 7.9%,...
Old age groups have different risk profile and stroke features compared to younger groups. Our aim was examine the factor subtype in patients older than 80 years with ischemic stroke. Data of 535 or transient attack (TIA) were prospectively recorded. Cardiovascular factors individuals aged under 80. Of a total 179 over (33.5%). The mean 84.4 +/- 4.4 (61.8%; 111 women). most common included hypertension (82.7%) hyperlipidemia (40.2%). Lacunar frequent (41.7%). When compared, we observed...
Objective: Objective and reproducible evaluation of data quality is paramount importance for studies ‘real-world’ observational data. Here, we summarise a standardised quality, density generalisability process implemented by MSBase, global multiple sclerosis (MS) cohort study. Methods: Error rate, score were developed using all 35,869 patients enrolled in MSBase as November 2015. The was calculated across six domains (follow-up, demography, visits, MS relapses, paraclinical therapy)...
Background: We need high-quality data to assess the determinants for COVID-19 severity in people with MS (PwMS). Several studies have recently emerged but there is great benefit aligning collection efforts at a global scale. Objectives: Our mission scale-up and provide community data-driven insights as soon possible. Methods: Numerous stakeholders were brought together. Small dedicated interdisciplinary task forces created speed-up formulation of study design work plan. First step was agree...
Autologous hematopoietic stem cell transplant (AHSCT) is available for treatment of highly active multiple sclerosis (MS).
previous reports have shown that in Dementia with Lewy body (DLB) and attention-deficit hyperactivity disorder (ADHD) a hypodopaminergic noradrenergic substrate seems to play central role developing the diseases. We investigated hypothesis attention deficit may precede DLB expressed as adult ADHD symptoms long before clinical onset of dementia.patients DLB, Alzheimer disease type (ADT) controls were recruited from membership Italian Hospital Medical Care Program Argentina 2000 2005. The...
The aim of this study was to compare brain atrophy in radiologically isolated syndrome (RIS), clinically (CIS), and individuals with subjective complaints (ISC).Patients RIS were included prospectively during June 2009 2012. CIS patients ISC used the sample. An automated analysis tool, SIENAX, obtain normalized total volume (NTBV), cortical (NCV), white matter (NWMV). ANOVA test analyze data.A 10 patients, 43 29 included. NTBV 1.56 mm(3) × 10(6) , 1.52 CIS, 1.64 (P = .12 vs. P .003 ISC); NCV...
<h3>Objective:</h3> To describe clinical and radiologic outcomes of children with incidental findings on neuroimaging suggestive CNS demyelination (termed "radiologically isolated syndrome" or RIS). <h3>Methods:</h3> Clinical data were obtained from a historical cohort no symptoms demyelinating disease who had MRI scans that met the 2010 criteria for dissemination in space MS. <h3>Results:</h3> We identified 38 (27 girls 11 boys) RIS now being prospectively followed at 16 sites 6 countries....
Cardiovascular risk factors (CRF) were widely described as related to dementia. There are very few studies regarding this association in FTD. The objective of the study was compare frequency CRF our population with FTD and controls. 100 consecutive subjects diagnosis according Lund-Manchester clinical criteria 200 controls matched by age sex included between January 2003 February 2007 at Cognitive Behavior Unit Hospital Italiano de Buenos Aires. Clinical evaluation, laboratory tests, brain...
Novel epidemiological data have appeared in recent years Latin America (LATAM). The objective of this study was to perform an updated systematic review the epidemiology disease reported LATAM.We conducted a published articles from January 1995 December 2016.Incidence were found four studies and ranged 0.3 3 annual cases per 100,000 person-years. Prevalence 13 0.83 38.2 inhabitants. Two showed increase prevalence incidence last five specific regions.The provides information on features MS...
Background Steps towards the development of diagnostic criteria are needed for children with radiologically isolated syndrome to identify at risk clinical demyelination. Objectives To evaluate 2005 and 2016 MAGNIMS magnetic resonance imaging dissemination in space multiple sclerosis, both alone oligoclonal bands cerebrospinal fluid added, as predictors a first event consistent central nervous system demyelination syndrome. Methods We analysed an international historical cohort 61 (≤18...
BackgroundNeuromyelitis optica spectrum disorders (NMOSD) is an increasing diagnostic and therapeutic challenge in Latin America (LATAM). Despite the heterogeneity of this population, ethnic socioeconomic commonalities exist, epidemiologic studies from region have had a limited geographic population outreach. Identification some aspects entire are lacking.ObjectivesTo determine ethnic, clinical characteristics, utilization tools types therapy for patients with NMOSD American...
Abstract Background People with multiple sclerosis (MS) are a vulnerable group for severe COVID-19, particularly those taking immunosuppressive disease-modifying therapies (DMTs). We examined the characteristics of COVID-19 severity in an international sample people MS. Methods Data from 12 data-sources 28 countries were aggregated. Demographic and clinical covariates queried, alongside outcomes, hospitalisation, admission to ICU, requiring artificial ventilation, death. Characteristics...