A5000907740- Multiple Sclerosis Research Studies
- Advanced MRI Techniques and Applications
- Ultrasound and Hyperthermia Applications
- Advanced Neuroimaging Techniques and Applications
- Peripheral Neuropathies and Disorders
- Polyomavirus and related diseases
- Systemic Lupus Erythematosus Research
- RNA regulation and disease
- Electron Spin Resonance Studies
- Ultrasound Imaging and Elastography
- Mycobacterium research and diagnosis
- Neuroinflammation and Neurodegeneration Mechanisms
- Glioma Diagnosis and Treatment
- Medical Image Segmentation Techniques
- Cell Image Analysis Techniques
- Radiation Dose and Imaging
- Neurogenesis and neuroplasticity mechanisms
- Viral Infections and Immunology Research
- CNS Lymphoma Diagnosis and Treatment
- MRI in cancer diagnosis
- Long-Term Effects of COVID-19
- Radiopharmaceutical Chemistry and Applications
- Cytokine Signaling Pathways and Interactions
- Hereditary Neurological Disorders
- Systemic Sclerosis and Related Diseases
University of Southern California
2016-2025
Keck Hospital of USC
2017-2024
Assembly of First Nations
2024
Yale University
2011-2023
Fayetteville Public Library
2022-2023
Ege University
2023
Simon Fraser University
2023
Memorial Sloan Kettering Cancer Center
2022
University of Michigan
2022
Columbia University Irving Medical Center
2022
We describe the clinical course of a patient with multiple sclerosis in whom progressive multifocal leukoencephalopathy (PML), an opportunistic viral infection central nervous system, developed during treatment interferon beta-1a and selective adhesion-molecule blocker, natalizumab. The first PML lesion apparent on magnetic resonance imaging was indistinguishable from lesion. Despite corticosteroids, cidofovir, intravenous immune globulin, progressed rapidly, rendering quadriparetic,...
Histopathological reports of multiple sclerosis and its animal models have shown evidence a link between axonal injury in active lesions impaired glutamate metabolism. Mature oligodendrocytes play role uptake to maintain homeostasis but white matter the loss expression transporters lesion vicinity results ineffective removal. Using magnetic resonance spectroscopy technique that isolates at 3 T, we compared levels normal subjects patients different brain areas. Metabolite concentrations...
Abstract Objective Magnetic resonance imaging at 7 Tesla produces high‐resolution gradient‐echo phase images of patients with multiple sclerosis (MS) that quantify the local field shifts from iron in basal ganglia and lesions. Phase is easily integrated into clinical examinations because it a postprocessing technique does not require additional scanning. The purpose this study was to MS investigate their relation disease duration disability status. Methods Thirty‐two subjects including 19 13...
Thalamic volume is a candidate magnetic resonance imaging (MRI)-based marker associated with neurodegeneration to hasten development of neuroprotective treatments. Our objective describe the longitudinal evolution thalamic atrophy in MS and normal aging, estimate sample sizes for study design.Six hundred one subjects (2,632 MRI scans) were analyzed. Five twenty relapse-onset (clinically isolated syndrome, n = 90; relapsing-remitting MS, 392; secondary progressive 38) underwent annual...
Increasing evidence indicates that the thalamus may be a location of early neurodegeneration in multiple sclerosis (MS). Our objective was to identify presence gray matter volume loss and thinning patients with radiologically isolated syndrome (RIS).Sixty-three participants were included this case-control study. Twenty-one RIS age- sex-matched 42 healthy controls 1:2 ratio. All underwent brain MRIs on single 3T scanner. After lesion segmentation inpainting, 1 mm(3)-isometric T1-weighted...
<h3>Objective:</h3> To investigate a potential effect of riluzole on serum neurofilaments (Nf) compared to placebo and the relationship between longitudinal clinical MRI outcomes Nf levels. <h3>Methods:</h3> Serum samples were obtained from participants enrolled in randomized double-blind trial neuroprotection with vs as an add-on weekly interferon-β (IFN-β)–1a IM initiated 3 months after randomization. measurements performed by ELISA electrochemiluminescence immunoassay. <h3>Results:</h3>...
The radiologically isolated syndrome (RIS) represents the earliest detectable pre-clinical phase of multiple sclerosis (MS). This study evaluated impact therapeutic intervention in preventing first symptom manifestation at this stage disease spectrum.We conducted a multi-center, randomized, double-blinded, placebo-controlled involving people with RIS. Individuals without clinical symptoms typical MS but incidental brain MRI anomalies consistent central nervous system (CNS) demyelination were...
The radiologically isolated syndrome (RIS) was defined in 2009 as the presence of asymptomatic, incidentally identified demyelinating-appearing white matter lesions CNS within individuals lacking symptoms typical multiple sclerosis (MS). RIS criteria have been validated and predict transition to symptomatic MS reliably. performance that require fewer MRI is unknown. 2009-RIS subjects, by definition, fulfil three four for 2005 dissemination space (DIS) subjects fulfilling only one or two at...
The presence and degree of neuronal degeneration already existing in patients at their initial presentation with a clinically isolated syndrome suggestive multiple sclerosis (CIS) is unclear, whole brain or normalised grey matter analyses have not demonstrated significant atrophy CIS cohorts clinical presentation. Voxel-based allow detection regional throughout the and, therefore, may be sensitive to patients, these changes correspond disability.This study used modified voxel-based...
Natalizumab is an effective treatment for patients with multiple sclerosis (MS) that associated a risk of progressive multifocal leukoencephalopathy (PML). Recommendations were published in 2006 to improve early diagnosis PML using magnetic resonance imaging (MRI). However, due the small number MS initially diagnosed PML, criteria could only be derived from lesions human immunodeficiency virus. Therefore, there urgent need assess MRI characteristics update existing recommendations. In this...
This trial examined the efficacy of a stress management program in reducing neuroimaging markers multiple sclerosis (MS) disease activity.A total 121 patients with relapsing forms MS were randomized to receive therapy for (SMT-MS) or wait-list control condition. SMT-MS provided 16 individual treatment sessions over 24 weeks, followed by 24-week post-treatment follow-up. The primary outcome was cumulative number new gadolinium-enhancing (Gd+) brain lesions on MRI at weeks 8, 16, and 24....
MR imaging can be used to measure structural changes in the brains of individuals with multiple sclerosis and is essential for diagnosis, longitudinal monitoring, therapy evaluation. The North American Imaging Multiple Sclerosis Cooperative steering committee developed a uniform high-resolution 3T protocol relevant quantification cerebral lesions atrophy implemented it at 7 sites across United States. To assess intersite variability scan data, we imaged volunteer relapsing-remitting MS...
Objective There is increasing evidence that altered glutamate (Glu) homeostasis involved in the pathophysiology of multiple sclerosis (MS). The aim this study was to evaluate vivo effects excess brain Glu on neuroaxonal integrity measured by N‐acetylaspartate (NAA), volume, and clinical outcomes a large, prospectively followed cohort MS subjects. Methods We used multivoxel spectroscopy at 3T longitudinally estimate NAA concentrations from large areas normal‐appearing white gray matter (NAWM...
To identify the top brain regions affected by MS-specific atrophy (i.e., in excess of normal aging) and to test whether aging increase or decrease these with age.Six hundred fifty subjects (2,790 MRI time points) were analyzed: 520 relapse-onset MS from a 5-year prospective cohort annual standardized 1-mm 3D T1-weighted images (3DT1s; 2,483 MRIs) 130 healthy controls longitudinal 3DT1s (307 MRIs). Rates change all FreeSurfer (v5.3) Structural Image Evaluation Using Normalization Atrophy...
Abstract Although multiple sclerosis has traditionally been considered a white matter disease, extensive research documents the presence and importance of grey injury including cortical deep regions. The exhibits broad range pathology is uniquely suited to study mechanisms clinical relevance tissue in using magnetic resonance techniques. Deep associated with cognitive disability. Recently, MRI characterization properties, such as thalamic volume, have tested potential trial end points...