A5002826474- Multiple Sclerosis Research Studies
- Long-Term Effects of COVID-19
- Click Chemistry and Applications
- DNA and Nucleic Acid Chemistry
- Autoimmune Neurological Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Mycobacterium research and diagnosis
- SARS-CoV-2 and COVID-19 Research
- PI3K/AKT/mTOR signaling in cancer
- RNA Interference and Gene Delivery
- Synthesis and Biological Evaluation
- Pediatric Hepatobiliary Diseases and Treatments
- COVID-19 Clinical Research Studies
- Cancer therapeutics and mechanisms
- Cardiac Arrest and Resuscitation
- Thermal Regulation in Medicine
- Drug Transport and Resistance Mechanisms
- Advanced biosensing and bioanalysis techniques
- Sphingolipid Metabolism and Signaling
- Tuberous Sclerosis Complex Research
- Quinazolinone synthesis and applications
- Effects of Radiation Exposure
- Chemical Synthesis and Analysis
- Respiratory Support and Mechanisms
- Polyomavirus and related diseases
Université de Reims Champagne-Ardenne
2018
Hôpital Maison Blanche
2018
Centre Hospitalier Universitaire de Reims
2018
Laboratoire de Chimie Organique
2001
Université de Montpellier
2001
Centre National de la Recherche Scientifique
2001
The radiologically isolated syndrome (RIS) was defined in 2009 as the presence of asymptomatic, incidentally identified demyelinating-appearing white matter lesions CNS within individuals lacking symptoms typical multiple sclerosis (MS). RIS criteria have been validated and predict transition to symptomatic MS reliably. performance that require fewer MRI is unknown. 2009-RIS subjects, by definition, fulfil three four for 2005 dissemination space (DIS) subjects fulfilling only one or two at...
A well-known mechanism leading to the emergence of multidrug-resistant tumor cells is overexpression P-glycoprotein, which capable lowering intracellular drug concentrations. In present study, we tested capability 2-pyrrolinodoxorubicin (p-DOX), a highly potent derivative DOX, bypass multidrug resistance. The accumulation, distribution and cytotoxicity p-DOX were in two cell lines (K562 A2780) their DOX-resistant counterparts (K562/ADR A2780/ADR). Cellular accumulation dramatically lowered...
Oligonucleotide models bearing 6, 12 or 18 histamine residues were synthesized on solid support and labeled with fluorescein. Only the oligo 6 showed a high uptake in HeLa cells nuclear localization. Experiment 4°C bafilomicyn A1 suggest that proceeded by an endocytosis mechanism followed destabilization of membrane. Once cytoplasm reached rapidly nucleus.