A5082131396- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- SARS-CoV-2 and COVID-19 Research
- Systemic Lupus Erythematosus Research
- Protein Tyrosine Phosphatases
- Systemic Sclerosis and Related Diseases
- vaccines and immunoinformatics approaches
- Bacillus and Francisella bacterial research
- Retinal and Optic Conditions
- Long-Term Effects of COVID-19
- Cardiovascular Function and Risk Factors
- Psychosomatic Disorders and Their Treatments
- Acute Lymphoblastic Leukemia research
- Vaccine Coverage and Hesitancy
- IL-33, ST2, and ILC Pathways
- Cardiovascular Effects of Exercise
- Genomic variations and chromosomal abnormalities
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- T-cell and Retrovirus Studies
- Sphingolipid Metabolism and Signaling
- Infectious Encephalopathies and Encephalitis
- Reproductive System and Pregnancy
- Research on Leishmaniasis Studies
- Poxvirus research and outbreaks
- Cerebrovascular and genetic disorders
Clínica Alemana
2020-2025
Clínica Dávila
2021-2025
Universidad del Desarrollo
2021-2025
Hospital Italiano de Buenos Aires
2025
Hospital General de Agudos Dr. TEODORO ALVAREZ
2021
McGill University
2013-2014
Montreal Neurological Institute and Hospital
2013-2014
Universidad de Los Andes, Chile
2005-2012
Hospital Clínico de la Universidad de Chile
2010-2011
University of Chile
2010
Clinical trial results demonstrating that B-cell depletion substantially reduces new relapses in patients with multiple sclerosis (MS) have established B cells play a role the pathophysiology of MS relapses. The same treatment appears not to impact antibodies directed against central nervous system, which underscores contribution antibody-independent functions disease activity. One mechanism by are now thought contribute activity is over-activating T cells, including through aberrant...
BackgroundNeuromyelitis optica spectrum disorders (NMOSD) is an increasing diagnostic and therapeutic challenge in Latin America (LATAM). Despite the heterogeneity of this population, ethnic socioeconomic commonalities exist, epidemiologic studies from region have had a limited geographic population outreach. Identification some aspects entire are lacking.ObjectivesTo determine ethnic, clinical characteristics, utilization tools types therapy for patients with NMOSD American...
Neuromyelitis optica spectrum disorder (NMOSD) is a severe autoimmune astrocytopathy mediated by aquaporin-4-immunoglobulin G (AQP4-IgG) antibodies, leading to complement-mediated neural injury. While ravulizumab, long-acting C5 inhibitor, approved for relapse prevention in AQP4-IgG-positive NMOSD, its role acute attacks remains unestablished. We report 58-year-old woman with highly relapsing course of NMOSD who developed fulminant attack bilateral corticospinal tract involvement, resulting...
Background: Neuromyelitis optica spectrum disorder (NMOSD) misdiagnosis (i.e. the incorrect diagnosis of patients who truly have NMOSD) remains an issue in clinical practice. We determined frequency and factors associated with NMOSD evaluated a cohort from Latin America. Methods: retrospectively reviewed medical records NMOSD, according to 2015 diagnostic criteria, referral clinics six American countries (Argentina, Chile, Paraguay, Colombia, Ecuador, Venezuela). Diagnoses prior ultimate...
To determine the range of fluctuation in total lymphocyte counts (TLCs) peripheral blood over a 4- to 7-year period patients with MS receiving fingolimod (FTY720) and relation between TLCs T-cell subsets (CD4+, CD8+, CCR7+/-) that are differentially regulated lymph nodes by fingolimod.TLCs were measured every 3 months (n = 23) for 4 7 years. subset analyses performed on whole-blood samples and/or freshly isolated or cryopreserved mononuclear cells.All serially studied had mean <0.6 × 10(9)...
Background: Vaccination against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first approved on 8th of December 2020. Though safe and effective, very rare side effects continue to be identified as global vaccination advances. They do not necessarily leave "a signal" in public registries if incidence remains below previously reported total levels. Optic neuritis (ON) is a but recognised adverse event after immunisation. The risk post-vaccination ON visual outcome...
To date, there are no data available on the safety of COVID-19 vaccines in Latin American patients with Multiple Sclerosis (MS).Characterize (LATAM) (pwMS).A cross-sectional study between February 1, 2021, and April 30, 2021. Individuals MS from LATAM countries were invited to participate a self-administered web-based survey, through patient organizations region.393 vaccinated pwMS 10 different included. The administered were: inactivated virus (IVV) 38.2% patients, adenovirus vector (AdV)...
Recent studies suggested that type 2 angiotensin receptor (AT2R) could contribute to regulation of blood pressure and/or vascular remodeling. A key question relates the effects potential modulators AT2R expression. In present work, we evaluated if high salt intake (70 mmol/L NaCl in drinking water) modulate rat mesenteric artery function and Angiotensin II dose-response curves were studied perfused pressurized small-diameter arteries presence losartan (AT1R antagonist). Arteries...
ABSTRACT Background: Despite the abundance of information concerning ocrelizumab in phase III clinical trials, there is scarce evidence regarding real-world patient profiles. Objective: The aim this study was to investigate profiles, effectiveness and persistence with treatment among patients who used for multiple sclerosis Latin America. Methods: This a retrospective multicenter Argentina, Chile Mexico. Medical record databases on received were analyzed. Demographic variables described,...
Optic neuritis (ON) is often the initial symptom of neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein-associated disease (MOGAD). We aimed to compare frequency pattern chiasmatic lesions in MOGAD-related ON (MOGAD-ON) NMOSD-related (NMOSD-ON) using conventional brain imaging (magnetic resonance [MRI]) Latin America (LATAM).We reviewed medical records MRI (≤30 days from onset) patients with a first event MOGAD-ON NMOSD-ON. Patients Argentina (n = 72),...
Determining the diagnosis of Crohn's disease has been highly difficult mainly during first years this study carried out at Pontificia Universidad Catolica (PUC) Clinical Hospital. For instance, it frequently confused with Irritable bowel syndrome and sometimes misdiagnosed as ulcerative colitis, infectious colitis or enterocolitis, intestinal lymphoma, coeliac disease. Consequently, seems advisable to characterize what most relevant clinical features are, in order establish a clear concept...
Monkeypox is a zoonotic viral disease that was identified in 1958 research monkeys came from Singapore. It an orthopoxvirus belongs to the Poxviridae family [1]. This infection restricted Africa but last year cases started raising not only rest of world [1,2]. why it became interest; important acknowledge its epidemiological behavior, risks and vaccines, especially recently struck by COVID-19, challenging physicians way treating vaccinating their immunosuppressed patients.