A5056722668- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Metal complexes synthesis and properties
- Organometallic Complex Synthesis and Catalysis
- Asymmetric Hydrogenation and Catalysis
- Crystallography and molecular interactions
- Magnetism in coordination complexes
- Metal-Organic Frameworks: Synthesis and Applications
- Ferrocene Chemistry and Applications
- Synthesis and Characterization of Heterocyclic Compounds
- Carbon dioxide utilization in catalysis
- DNA and Nucleic Acid Chemistry
- Nanomaterials for catalytic reactions
- Chemical Synthesis and Analysis
- Catalytic Cross-Coupling Reactions
- Catalytic C–H Functionalization Methods
- Chemical Reactions and Isotopes
- Radical Photochemical Reactions
- Catalytic Alkyne Reactions
- Click Chemistry and Applications
- Catalysis for Biomass Conversion
- Lanthanide and Transition Metal Complexes
- Molecular Sensors and Ion Detection
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Asymmetric Synthesis and Catalysis
University of Castilla-La Mancha
2015-2024
Hospital General Universitario de Ciudad Real
2020
Rede de Química e Tecnologia
2020
Universidad de Ciencias Médicas de la Habana
2015
Hospital Oncológico Docente "Conrado Benítez García"
2010-2013
Instituto de Química Médica
2007
University of Vienna
2002-2006
University of Havana
2006
Universidad de Burgos
2004-2005
Universitat Autònoma de Barcelona
2004-2005
One approach to reduce the side effects of chemotherapy in cancer treatment is photodynamic therapy (PDT), which allows spatiotemporal control cytotoxicity. We have used strategy coordinating π-expansive ligands increase excited state lifetimes Ir(III) half-sandwich complexes order facilitate generation 1O2. obtained derivatives formulas [Cp*Ir(C∧N)Cl] and [Cp*Ir(C∧N)L]BF4 with different degrees π-expansion C∧N ligands. Complexes more ligand are very effective photosensitizers phototoxic...
To assess the age at menopause (AM) in Latin America urban areas.A total of 17,150 healthy women, aged 40 to 59 years, accompanying patients healthcare centers 47 cities 15 American countries, were surveyed regarding their age, educational level, coverage, history gynecological surgery, smoking habit, presence menses, and use contraception or hormone therapy menopause. The AM was calculated using logit analysis.The mean entire sample 49.4 +/- 5.5 years. Mean level 9.9 4.5 oral 22.1% 7.9%,...
Ruthenium derivatives of the type [RuCl(arene)(NN)][BPh4] (arene = benzene, p-cymene) have been synthesized with NN 2-hydroxyphenylbis(pyrazol-1-yl)methane (bpzmArOH) or 2-hydroxyphenylbis(3,5-dimethylpyrazol-1-yl)methane (bpz*mArOH). In p-cymene derivative containing bpzmArOH, activation hydroxy group is observed and a scorpionate complex obtained ligand behaving in tridentate manner, [Ru(bpzmArO-κ3-N,N,O)(p-cymene)][BPh4]. The structure this that [RuCl(p-cymene)(bpz*mArOH)][BPh4] were...
The ligands 2-pyridin-2-yl-1H-benzimidazole (HL1), 1-methyl-2-pyridin-2-ylbenzimidazole (HL2), and 2-(1H-imidazol-2-yl)pyridine (HL3) the proligand 2-phenyl-1H-benzimidazole (HL4) have been used to prepare five different types of new ruthenium(II) arene compounds: (i) monocationic complexes with general formula [(η6-arene)RuCl(κ2-N,N-HL)]Y [HL = HL1, HL2, or HL3; Y Cl BF4; 2-phenoxyethanol (phoxet), benzene (bz), p-cymene (p-cym)]; (ii) dicationic aqua [(η6-arene)Ru(OH2)(κ2-N,N-HL1)](Y)2 (Y...
ADVERTISEMENT RETURN TO ISSUEPREVArticle19F and 31P NMR evidence for silver hexafluorophosphate hydrolysis in solution. New palladium difluorophosphate complexes x-ray structure determination of [Pd(.eta.3-2-Me-C3H4)(PO2F2)(PCy3)]Rafael Fernandez-Galan, Blanca R. Manzano, Antonio Otero, Maurizio Lanfranchi, Maria Angela PellinghelliCite this: Inorg. Chem. 1994, 33, 10, 2309–2312Publication Date (Print):May 1, 1994Publication History Published online1 May 2002Published inissue 1...
The reaction of [NBun4][AuR2](R = C6F5 or C6F3H2-2,4,6) with Ag[ClO4] leads to complexes [{AuAgR2}n], which react neutral ligands give [{AuAgR2L}n](L O-, N-, S- P-donor ligand, alkene, alkyne). For R and L diphenylacetylene, the product is [{AuAgR2·0.5L}n]; 0.5L can be displaced by other ligands, such as acetone, arenes, alkenes, reform [{AuAgR2L}n]. An X-ray diffraction study [{AuAgR2L}n](R C6F5, tetrahydrothiophene) reveals (AuAg)2 rings Au–Ag 2.726 2.718 Å(the first reported bond...
The synthesis and full characterization of the new aqua-complex [(η6-p-cymene)Ru(OH2)(κ2-N,N-2-pydaT)](BF4)2, [2](BF4)2, nucleobase derivative [(η6-p-cymene)Ru(9-MeG)(κ2-N,N-2-pydaT)](BF4)2, [4](PF6)2, where 2-pydaT = 2,4-diamino-6-(2-pyridyl)-1,3,5-triazine 9-MeG 9-methylguanine, are reported here. crystal structures both [4](PF6)2 chloro complex [(η6-p-cymene)RuCl(κ2-N,N-2-pydaT)](PF6), [1](PF6), have been elucidated by X-ray diffraction. former provided relevant information regarding...
(Aminoferrocenyl)phosphine ligands 2-(1-(dimethylamino)ethyl)-1-(diphenylphosphino)ferrocene (PPFA) and [η5-cyclopentadienyl][η5-4-(endo-dimethylamino)-3-(diphenylphosphino)-4,5,6,7-tetrahydro-1H-indenyl]iron(II) (PTFA), were used as in palladium(0) -(II) complexes. The reaction of Pd2(dba)3·CHCl3 with PPFA or PTFA the presence electron-withdrawing olefins maleic anhydride (MA) dimethyl fumarate (DMFU) gave complexes Pd(PTFA)(DMFU) (2), Pd(PPFA)(MA) (3), Pd(PPFA)(DMFU) (4). Allylic...
Abstract A new and safer methodology has been developed for the synthesis of bis(pyrazol‐1‐yl)methane ligands (NN). Several containing different phenyl groups on central carbon atom have obtained. Ruthenium derivatives type [Ru(arene)Cl(NN)]BPh 4 (arene = benzene, p ‐cymene) synthesised using these ligands. One or two isomers that differ regarding axial equatorial disposition group metallacycle Their formation is rationalised by considering steric effects. The structures five were determined...
The ligands 4,6-bis(pyrazol-1-yl)pyrimidine (bpzpm), 4,6-bis(3,5-dimethylpyrazol-1-yl)pyrimidine (bpz*pm), 4,6-bis(4-methylpyrazol-1-yl)pyrimidine (Mebpzpm), and 3,6-bis(3,5-dimethylpyrazol-1-yl)pyridazine (ppdMe) were synthesized made to react with Cu(I) centers in the presence of different counteranions. Different [2 × 2] metallic grids obtained. With bpzpm, bpz*pm, Mebpzpm, a new type grid was obtained where facing divergent two counteranions (BF4- or PF6-) hosted resulting cavities...
New coordination polymers have been obtained by the self-assembly of silver salts AgX (X = BF 4, PF 6, CF 3SO 3) and 2,4-diamino-6-R-1,3,5-triazines L (R phenyl p-tolyl) formulas AgLX ( 1- 6). A complex different stoichiometry, [Ag 3L 2(H 2O)(acetone) 2](BF 4) 3, 7 phenyl), has also synthesized. The three-dimensional structures five compounds determined X-ray diffraction studies. For complexes, when X 4 R or p-tolyl, chiral chains with alternating Ag are formed. cross-linked counteranions in...
The synthesis of octahedral copper and zinc coordination complexes containing ligands the type 6R,2,4-bis(3,5-dimethylpyrazol-1-yl)triazine is described. They exhibit simultaneous presence C-H/pi anion-pi interactions on both sides same triazine ring. When pyrazolyl groups are not methylated, lone pair-pi coexist In addition, interplay between studied by means high level correlation ab initio calculations. demonstrate that synergistic effects present when coexist. These have been evaluated...
The preparation of three series arene Ru(II) half-sandwich compounds with the functional ligand 4,4′-dimethoxy-2,2′-bipyridine (dmobpy) is described. new cationic derivatives have general formula [(η6-arene)RuCl(κ2-N,N-dmobpy)]X (arene = benzene, X Cl– ([1]Cl), BF4– ([1][BF4]), TsO– ([1]TsO), PF6– ([1][PF6]); p-cymene (p-cym), ([2]Cl), ([2][BF4]), ([2]TsO), ([2][PF6]); 2-phenoxy-1-ethanol (phoxet), ([3]Cl), ([3][BF4]), ([3]TsO), ([3][PF6])). structures [1]Cl, [1]TsO, [2]TsO, [2][BF4], and...
The new complex [(η6-p-cym)RuCl(κ2-N,N-dmbpy)](BF4) (p-cym = p-cymene; dmbpy 4,4′-dimethyl-2,2′-bipyridine) is water-soluble and active in the catalytic transfer hydrogenation (TH) of different ketones (cyclohexanone, 2-cyclohexenone, 3-pentanone) to corresponding alcohols using aqueous HCOONa/HCOOH as hydrogen source at pH 4.4. A higher activity was found for TH imine N-benzylideneaniline under same conditions. Excellent results have been obtained catalyst recycling. Aqua, formato, hydrido...
The synthesis and characterization of Pt(II) (1 2) Ru(II) arene (3 4) or polypyridine (5 6) complexes is described. With the aim having a functional group to form bioconjugates, one uncoordinated carboxyl has been introduced in all complexes. Some were selected for their potential photodynamic therapy (PDT). molecular structures 2 5, as well that sodium salt 4'-(4-carboxyphenyl)-2,2':6',2″-terpyridine ligand (cptpy), determined by X-ray diffraction. Different techniques used evaluate binding...
Considering the interest in processes related to hydrogen storage such as CO2 hydrogenation and formic acid (FA) decomposition, we have synthesized a set of Ir, Rh, or Ru complexes be tested versatile precatalysts these reactions. In relation with formation H2 from FA, possible applicability transfer (TH) challenging substrates quinoline derivatives using FA/formate donor has also been addressed. Bearing mind importance secondary coordination sphere interactions, N,N' ligands containing NH2...
Photoredox catalysis constitutes a very powerful tool in organic synthesis, due to its versatility, efficiency, and the mild conditions required by photoinduced transformations. In this paper, we present an efficient selective photocatalytic procedure for aerobic oxidative dehydrogenation of partially saturated N-heterocycles afford respective N-heteroarenes (indoles, quinolines, acridines, quinoxalines). The protocol involves use new Ir(III) biscyclometalated photocatalysts general formula...
Complexes of formula [RuCl2(arene)(κ1-dpim)] (dpim = 2-(diphenylphosphino)-1-methylimidazole) (arene p-cymene, 1a; C6H6, 1b) were prepared by the reaction [RuCl2(p-cymene)]2 or [RuCl2(C6H6)(CH3CN)] with dpim. 1a and 1b structurally characterized NMR spectroscopy X-ray diffraction. The these precursors BF4- salts led, in dichloromethane, to cationic complexes [RuCl(arene)(κ2-dpim)]BF4 2a; 2b). However, methanol products unexpected phosphinite derivatives type...
Abstract The reactions of two diaminotriazine ligands 2,4‐diamino‐6‐(2‐pyridyl)‐1,3,5‐triazine (2‐pydaT) and 6‐phenyl‐2,4‐diamino‐1,3,5‐triazine (PhdaT) with ruthenium–arene precursors led to a new family ruthenium(II) compounds that were spectroscopically characterized. Four the complexes cationic, general formula [( η 6 ‐arene)Ru( κ 2 ‐ N , ‐2‐pydaT)Cl]X (X=BF 4 TsO; arene= p ‐cymene: 1.BF4 1.TsO arene=benzene: 2.BF4 2.TsO ). neutral cyclometalated complex ‐cymene)Ru( C ‐PhdaT*)Cl] ( 3 )...
New cationic, half-sandwich Ru(II) arene compounds of general formula [(η(6)-arene)RuCl(κ(2)-N,N-L)]X (where L are functionalized phenanthrolines such as 1,10-phenanthroline-5-amine (aphen); 5,6-epoxy-5,6-dihydro-[1,10]phenanthroline (ephen); or 4,7-dihydroxy-1,10-phenanthroline (dhphen)) have been prepared to study their anticancer potential. All the isolated complexes fully characterized by spectroscopic and analytical techniques. The structure...
Despite their outstanding properties as potential photosensitizers for photodynamic therapy (PDT), Ir(III) biscyclometalated complexes need both further developments to overcome remaining limitations and in-depth investigations into mechanisms of action reach clinic application in the treatment cancer. This work describes synthesis a family general formula [Ir(C^N)2(N^N′)]Cl (N^N′ = thiabendazole-based ligands; C^N ppy (2-phenylpyridinate) (Series A), or dfppy...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFirst Observation in a Niobium Complex of the Rotation Coordinated H-D Molecule Blocked at NMR Time ScaleFelix A. Jalon, Antonio Otero, Blanca R. Manzano, Elena Villasenor, and Bruno ChaudretCite this: J. Am. Chem. Soc. 1995, 117, 40, 10123–10124Publication Date (Print):October 1, 1995Publication History Published online1 May 2002Published inissue 1 October...
Four new enantiopure homo- and heteroannularly bridged ferrocenyl diphosphine ligands have been synthesized, characterized, tested in enantioselective hydrogenations of olefins [methyl-(Z)-(α)-(acetamido)cinnamate, (Z)-(α)-methylcinnamic acid dimethyl itaconate], ketones (ethyl pyruvate, methyl phenylglyoxylate, ketopantolactone), the imine 2-ethyl-N-(2-methoxy-1-methylethylidene)-6-methylbenzeneamine (MEAI). Generally, homoannularly ligand...
The self-assembly of the ligands bis(pyrazol-1-yl)(pyridine-4-yl)methane (L1) and bis(3,5-dimethylpyrazol-1-yl)(pyridine-4-yl)methane (L2) with AgBF4 leads to three types species: L1 gives rise formation a boxlike cyclic dimer (1) while L2 two different coordination polymers that are sequence isomers. With dependence on crystallization conditions, either homochiral helix (2) spontaneous resolution or zigzag polymer is formed (3). By means solid-state circular dichroism studies, presence both...