A5016987609- Multiple Sclerosis Research Studies
- Neurogenesis and neuroplasticity mechanisms
- Spinal Dysraphism and Malformations
- Neuroinflammation and Neurodegeneration Mechanisms
- Acute Lymphoblastic Leukemia research
- Rheumatoid Arthritis Research and Therapies
- Statistical Methods and Inference
- TGF-β signaling in diseases
- Health, Environment, Cognitive Aging
- Peripheral Neuropathies and Disorders
- Axon Guidance and Neuronal Signaling
- Effects of Vibration on Health
- Advanced Neuroimaging Techniques and Applications
- Wireless Body Area Networks
- Adenosine and Purinergic Signaling
- Phagocytosis and Immune Regulation
- Neuroscience and Neuropharmacology Research
- Telemedicine and Telehealth Implementation
- Human-Automation Interaction and Safety
- Bioinformatics and Genomic Networks
- Family Support in Illness
- Reproductive System and Pregnancy
- Immunotherapy and Immune Responses
- Polyomavirus and related diseases
- COVID-19 epidemiological studies
Monash University
2017-2025
Eastern Health
2017-2025
Box Hill Hospital
2017-2024
The Royal Melbourne Hospital
2017-2021
The University of Melbourne
2010-2021
John Hunter Hospital
2021
Florey Institute of Neuroscience and Mental Health
2010-2021
Royal Hobart Hospital
2021
University of Newcastle Australia
2021
The University of Sydney
2021
ABSTRACT Background Cognitive impairment is one of the most common and debilitating symptoms relapsing–remitting multiple sclerosis (RRMS). Digital cognitive biomarkers require less time resources are rapidly gaining popularity in clinical settings. We examined longitudinal trajectory iPad‐based Processing Speed Test (PST) predictors PST scores. Methods prospectively enrolled RRMS patients between 2017 2021 across six Australian MS centres. Longitudinal data was analysed with mixed effect...
Remyelination of the CNS involves regeneration mature oligodendrocytes by endogenous oligodendrocyte progenitor cells (OPCs). Previous studies have shown that bone morphogenic proteins (BMPs) inhibit production in healthy CNS. However, there is currently no information on influence BMP signaling vivo within demyelinated lesions brain or subsequent remyelination. Here, we determine a role for modulating oligodendrogliogenesis and remyelination following cuprizone-induced demyelination. We...
Importance Natalizumab cessation is associated with a risk of rebound disease activity. It important to identify the optimal switch disease-modifying therapy strategy after natalizumab limit severe relapses. Objectives To compare effectiveness and persistence dimethyl fumarate, fingolimod, ocrelizumab among patients relapsing-remitting multiple sclerosis (RRMS) who discontinued natalizumab. Design, Setting, Participants In this observational cohort study, patient data were collected from...
Background Ongoing controversy exists regarding optimal management of disease modifying therapy (DMT) in older people with multiple sclerosis (pwMS). There is concern that the lower relapse rate, combined a higher risk DMT-related infections and side effects, may alter risk-benefit balance pwMS. Given lack pwMS above age 60 randomised controlled trials, comparative efficacy high-efficacy DMTs such as ocrelizumab has not been shown We aimed to evaluate effectiveness ocrelizumab, DMT, versus...
The adult subventricular zone (SVZ) is a potential source of precursor cells to replace neural lost during demyelination. To better understand the molecular events that regulate cell responsiveness in this context we undertook microarray and quantitative PCR based analysis genes expressed within SVZ cuprizone-induced We identified an up-regulation encoding bone morphogenic protein 4 (BMP4) its receptors. Immunohistochemistry confirmed increase BMP4 levels also showed phosphorylated SMAD...
Abstract Astrocytes are a target for regenerative neurobiology because in brain injury their phenotype arbitrates integrity, neuronal death and subsequent repair reconstruction. We explored the ability of 3D scaffolds to direct astrocytes into phenotypes with potential support survival. Poly‐ε‐caprolactone were electrospun random aligned fibre orientations on which murine sub‐cultured analysed at 4 12 DIV. survived, proliferated migrated adopting morphologies, mimicking vivo stellated...
Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. The risk developing MS strongly influenced by genetic predisposition, and over 100 loci have been established as associated with susceptibility. However, biologically relevant variants underlying not defined for vast majority these loci, limiting power studies to define new avenues research development therapeutics. It therefore crucial that candidate susceptibility are carefully...
Inhibitors of Rho kinase (ROCK) have potential for management neurological disorders by inhibition glial scarring. Since astrocytes play key roles in brain physiology and pathology, we determined changes the astrocytic transcriptome produced ROCK inhibitor Fasudil to obtain mechanistic insights into its beneficial action during injury. Cultured murine were treated with (100 µM) morphological analyses revealed rapid stellation 1 h time-dependent (2-24 h) dissipation F-actin-labelled stress...
The validity, reliability, and longitudinal performance of the Patient-Determined Disease Steps (PDDS) scale is unknown in people with multiple sclerosis (MS) mild to moderate disability. We aimed examine psychometric properties PDDS.
Background: Monitoring of cognition in multiple sclerosis (MS) is critical. Traditional cognitive testing resource intensive and insensitive to subtle changes. Digital tests could address this need; however, their long-term usability remains unexplored. Objectives: To determine the acceptability feasibility digital measures MS. Methods: Participants with relapsing or secondary progressive MS were prospectively enrolled. MSReactor, a web-based test evaluating processing speed, attention...
Blocking inhibitory factors within CNS demyelinating lesions is regarded as a promising strategy to promote remyelination. Bone morphogenetic protein 4 (BMP4) an factor present in lesions. Noggin, endogenous antagonist BMP, has previously been shown increase the number of oligodendrocytes and remyelination vivo. However, it remains unclear how BMP4 signaling inhibits Here we investigated downstream pathway that mediates effect exerts upon through pharmacological transgenic approaches. Using...
Background To compare the effectiveness and treatment persistence of ocrelizumab, cladribine natalizumab in patients with relapsing–remitting multiple sclerosis switching from fingolimod. Methods Using data MSBase registry, this multicentre cohort study included subjects who had used fingolimod for ≥6 months then switched to or within 3 after discontinuation. We analysed relapse disability outcomes balancing covariates using an inverse-probability-treatment-weighting method. Propensity...
Abstract Background Upper limb dysfunction is a common debilitating feature of relapsing‐remitting multiple sclerosis (RRMS). We aimed to examine the longitudinal trajectory iPad®‐based Manual Dexterity Test (MDT) and predictors change over time. Methods prospectively enrolled RRMS patients (limited Expanded Disability Status Scale (EDSS) < 4). Longitudinal data was analysed using mixed‐effect modelling latent class mixed models. then examined whether group membership in classes predicted...
Multiple sclerosis (MS) cognitive tests are resource intensive and limited by practice effects that prevent frequent retesting. Brief, reliable valid monitoring tools urgently needed to detect subtle, subclinical changes in people with MS. Cognitive over time could contribute a new definition of disease progression, supplementing routine clinical monitoring.MSReactor is web-based battery measures psychomotor (processing) speed, visual attention working memory, using simple reaction tasks....
Background Cognitive monitoring that can detect short-term change in multiple sclerosis is challenging. Computerized cognitive batteries such as the CogState Brief Battery rapidly assess commonly affected domains. Objectives The purpose of this study was to establish acceptability and sensitivity patients compared controls. We Paced Auditory Serial Addition Test over 12 months. Methods Demographics, Expanded Disability Status Scale scores, depression anxiety scores were with performances 51...
Longitudinal cognitive trajectories in multiple sclerosis are heterogeneous and difficult to measure. We aimed identify discrete longitudinal reaction time relapsing-remitting using a computerized battery assess the association between of disability progression.All participants serially completed tasks measuring psychomotor speed, visual attention, working memory. Participants at least 3 testing sessions over minimum 180 days. times were modeled with latent class mixed models groups...
The relationship between coronavirus disease 2019 (COVID-19) infection and multiple sclerosis (MS) relapse progression remains unclear. Previous studies are limited by small sample sizes most lack a propensity-matched control cohort.