A5051412598- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- Nerve injury and regeneration
- Vestibular and auditory disorders
- Botulinum Toxin and Related Neurological Disorders
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Neurogenesis and neuroplasticity mechanisms
- Amyotrophic Lateral Sclerosis Research
- Mitochondrial Function and Pathology
- Balance, Gait, and Falls Prevention
- Motor Control and Adaptation
- Autism Spectrum Disorder Research
- Neuroinflammation and Neurodegeneration Mechanisms
- EEG and Brain-Computer Interfaces
- Tissue Engineering and Regenerative Medicine
- Neurogenetic and Muscular Disorders Research
- Electrospun Nanofibers in Biomedical Applications
- Nicotinic Acetylcholine Receptors Study
- Neuroscience and Neural Engineering
- Library Science and Information Systems
- Voice and Speech Disorders
- Neural dynamics and brain function
The University of Melbourne
2014-2024
St Vincent's Hospital
2015-2024
Bionics Institute
2023-2024
Florey Institute of Neuroscience and Mental Health
2014-2023
Mental Health Australia
2017
St Vincent's Health
2016
Monash Health
1997-2014
St. Vincent's Birmingham
2009-2013
Neuroscience Institute
2011
Monash Institute of Medical Research
2010
Abstract Transformation of foetal human leukocytes followed inoculation with a filtrate cells the QIMR‐WIL leukocyte cell line, previously shown to carry herpes‐like virus. Proliferation was generally noted 24–35 days after inoculation, and resulted in establishment lines resembling those derived from peripheral patients leukaemia or infectious mononucleosis. The sex representative transformed confirmed that they were origin. occurred two separate filtrates cells, five individual foetuses,...
Recent reports of autoantibodies that bind to neuronal surface receptors or synaptic proteins have defined treatable forms autoimmune encephalitis. Despite these developments, many cases encephalitis remain unexplained. We previously described a basal ganglia with dominant movement and psychiatric disease, proposed an aetiology. Given the role dopamine in control behaviour, we hypothesized patients other putative disorders harboured serum against important proteins. Basal sera immunolabelled...
There is a need for objective measures of dyskinesia and bradykinesia Parkinson's disease (PD) that are continuous throughout the day related to levodopa dosing. The output an algorithm calculates scores every two minutes over 10 days (PKG: Global Kinetics Corporation) was compared with conventional rating scales PD in subjects. recognises as movements made lower acceleration amplitude longer intervals between movement. Similarly having normal but shorter periods without distribution from...
Myopathy complicating the therapy of severe asthma has been recently described in several case reports. Twenty-five consecutive patients admitted to intensive care unit (ICU) at this hospital for mechanical ventilation were studied incidence creatine kinase (CK) enzyme rise and development clinical myopathy. Pharmacologic was standardized, every patient receiving corticosteroids aminophylline intravenously salbutamol both nebulized intravenously. Twenty-two received muscle relaxant with...
Mutations in Cu/Zn superoxide dismutase (SOD1) are linked to motor neuron death familial amyotrophic lateral sclerosis (ALS) by an unclear mechanism, although misfolded SOD1 aggregates commonly associated with disease. Proteomic analysis of the transgenic SOD1G93A ALS rat model revealed significant up-regulation endoplasmic reticulum (ER)-resident protein-disulfide isomerase (PDI) family members lumbar spinal cords. Expression mutants (mSOD1) led PDI neuron-like NSC-34 cells but not other...
Abstract This study compares the basal ganglia of rats, marmosets, macaques, baboons, and humans. It uses established protocols to estimate volume number neurons within output nuclei (internal globus pallidus, IGP; nondopaminergic substantia nigra, SNND), two internal relay modulating (subthalamic nucleus, STh; external EGP), a modulator striatum (dopaminergic SND). Nuclear boundaries were defined by using immunohistochemistry for striatal afferents. Total numbers Nissl‐stained...
In order to examine the role of basal ganglia (BG) in regulation basic movement parameters, we recorded extracellularly from pallidal neurons conscious monkeys during performance a sequential wrist task which was composed series holds and ballistic jumps. The sequence predictable had be performed within specified time restraints. We activity 297 whose discharges were related task. included only movements at or about joint by prior examination outside behavioural paradigm. Each neuron...
In order to study the role of basal ganglia (BG) in cognitive aspects movement, we recorded extracellularly from pallidal neurons conscious monkeys while they performed a sequential wrist movement task consisting series holds and ballistic jumps. The sequence had be within specified time restraints was predictable. We activity 297 whose discharges were related task. movement-related response found influenced by contextual setting degree difficulty subgroup 82 with clear first movement....
Neuronal nicotinic acetylcholine receptors (nAChR) are present in high abundance the nervous system (Decker et al., 1995). There a large number of subunits expressed brain that combine to form multimeric functional receptors. We have generated an α<sub>4</sub>nAChR subunit knock-out line and focus on defining behavioral role this receptor subunit. Homozygous mutant mice (Mt) normal size, fertility, home-cage behavior. Spontaneous unconditioned motor behavior revealed ethogram characterized...
In amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration, TAR DNA binding protein 43 (TDP-43) accumulates in the cytoplasm of affected neurons glia, where it associates with stress granules (SGs) forms large inclusions. SGs form response to cellular stress, including endoplasmic reticulum (ER) which is induced both familial sporadic ALS. Here we demonstrate that pharmacological induction ER causes TDP-43 accumulate cytoplasm, also SGs. Furthermore, treatment salubrinal,...
Attempts to repair the central nervous system damaged as a result of trauma or disease will depend on ability restore appropriate neuronal connectivity. This rely establishing chemical and physical environments for supporting neural cells their processes in this regard, engineering biomaterials is increasing interest. It be important understand how behave these vitro, prior future vivo application. We reveal that modification 3-dimensional (3D) electrospun poly-epsilon-caprolactone (PCL)...
Amyotrophic lateral sclerosis is a rapidly progressing fatal neurodegenerative disease characterized by the presence of protein inclusions within affected motor neurons. Endoplasmic reticulum stress leading to apoptosis was recently recognized be an important process in pathogenesis sporadic human amyotrophic as well transgenic models mutant superoxide dismutase 1-linked familial sclerosis. occurs early disease, indicating critical role pathogenesis, and involves upregulation endoplasmic...
The phenomenological effects of deep brain stimulation (DBS) on the self patient remains poorly understood and under described in literature, despite growing evidence that a significant number patients experience postoperative neuropsychiatric changes. To address this lack evidence, we conducted in-depth, semistructured interviews with 17 Parkinson's disease who had undergone DBS. Exploring subjective character specific to patients' being implanted gives empirical conceptual understanding...
Aromatase catalyses the last step of oestrogen synthesis. There is growing evidence that local oestrogens influence many brain regions to modulate development and behaviour. We examined, by immunohistochemistry, expression aromatase in adult male female mouse brain, using mice which enhanced green fluorescent protein (EGFP) transcribed following physiological activation Cyp19A1 gene. EGFP-immunoreactive processes were distributed regions, including bed nucleus stria terminalis, olfactory...