A5021179047- Cerebral Palsy and Movement Disorders
- Neonatal Respiratory Health Research
- Metabolism and Genetic Disorders
- Epigenetics and DNA Methylation
- Hydrogels: synthesis, properties, applications
- Tissue Engineering and Regenerative Medicine
- Neonatal and fetal brain pathology
- Electrospun Nanofibers in Biomedical Applications
- Family and Disability Support Research
- Nerve injury and regeneration
- Autism Spectrum Disorder Research
- Proteins in Food Systems
- Advanced Drug Delivery Systems
- Mitochondrial Function and Pathology
- Infant Development and Preterm Care
- Polymer Surface Interaction Studies
- Genomics and Rare Diseases
- Semiconductor materials and devices
- Health Systems, Economic Evaluations, Quality of Life
- Surgical Sutures and Adhesives
- Spinal Dysraphism and Malformations
- Ectopic Pregnancy Diagnosis and Management
- RNA Interference and Gene Delivery
- Mesenchymal stem cell research
- Biomedical Text Mining and Ontologies
Murdoch Children's Research Institute
2014-2025
Royal Children's Hospital
2016-2025
The University of Melbourne
2015-2025
Monash University
2003-2009
Cooperative Research Centre for Polymers
2005-2008
Molina Center for Energy and the Environment
2007
Australian Regenerative Medicine Institute
2004
Germline loss-of-function variants in CTNNB1 cause neurodevelopmental disorder with spastic diplegia and visual defects (NEDSDV; OMIM 615075) are the most frequent, recurrent monogenic of cerebral palsy (CP). We investigated range clinical phenotypes owing to disruptions determine association between NEDSDV CP.Genetic information from 404 individuals collectively 392 pathogenic were ascertained for study. From these, detailed 52 previously unpublished collected combined 68 published...
Journal Article Evaluation of a Novel Biodegradable Polymer for the Generation Dermal Matrix Get access Ami Li, BSc(Hons), BSc(Hons) *Burns Unit/Skin Engineering Laboratory, Royal Adelaide Hospital, South Australia, Australia Search other works by this author on: Oxford Academic Google Scholar Bronwyn L. Dearman, Kylie E. Crompton, PhD, PhD †PolyNovo Biomaterials Ltd., Victoria, Timothy G. Moore, John Greenwood, AM, MB ChB, MD, FRCS(Plast), FRACS **Address correspondence to Burns Unit, North...
Cerebral palsy (CP) is a clinical description for group of motor disorders that are heterogeneous with respect to causes, symptoms and severity. A diagnosis CP cannot usually be made at birth in some cases may delayed until 2-3 years age. This limits opportunities early intervention could otherwise improve long-term outcomes. has been recorded monozygotic twins discordant the disorder, indicating potential role non-genetic factors such as intrauterine infection, hypoxia-ischaemia,...
Abstract Aim To explore factors contributing to the burden of respiratory admissions in children with severe cerebral palsy (CP) by comparing a single tertiary paediatric hospital before, during, and after period social restrictions implemented reduce transmission COVID‐19 (lockdown period). Method For this observational study, three CP cohorts (pre‐lockdown, lockdown, post‐lockdown) were identified from state‐wide register linked patient‐level clinical demographic data. Medical records...
Chitosan–glycerophosphate (GP) is a physiological pH solution at room temperature which forms physical hydrogel upon heating to 37 °C. The suitable for biomedical applications and in particular as biodegradable scaffold tissue engineering. Since the structure of critical cell–material interactions, small angle neutron scattering (SANS) ultra SANS (USANS) were used examine molecular conformation chitosan chains larger scale microstructure. On nanoscale, described terms static component...
Introduction Cerebral palsy (CP) is the most common physical disability of childhood but has no cure. Stem cells have potential to improve brain injury and are proposed as a therapy for CP. However, many questions remain unanswered about appropriate cell type, timing infusions, dose required associated risks. Therefore, human safety efficacy trials necessary progress knowledge in field. Methods analysis This single group study with sample size n=12 investigate single-dose intravenous 12/12...
The aim of this study was to describe the patterns therapy service use for a sample children and adolescents with cerebral palsy over 1 year period identify factors associated frequency parental satisfaction frequency.Parents 83 completed survey on their child's occupational therapy, physiotherapy speech language pathology services previous year. Participants were randomly selected from stratified by age Gross Motor Function Classification System (GMFCS) level.During prior completion, 83%...
Aim Umbilical cord blood may have therapeutic benefit in children with cerebral palsy ( CP ), but further studies are required. On first appearance it seems that A ustralia is well placed for such a trial because we excellence research backed by extensive registers, and both public private banks. We aimed to examine the possibilities of conducting autologous umbilical cells UCBCs ) as treatment ustralia. Methods Data linkages between registers banks were used estimate potential participant...
Abstract Introduction Umbilical cord blood (UCB) is a novel treatment for cerebral palsy (CP) with clinical trials indicating UCB safe and can improve gross motor function. However, heterogeneity across research design, participant selection protocols has limited the ability to interpret overall effect, identify best responders dosing thresholds. Objectives We sought conduct systematic review individual data meta-analysis (IPDMA) 1) determine effect of measured by Gross Motor Function...