A5046943484- Neuroscience and Neural Engineering
- Nerve injury and regeneration
- Nanoparticle-Based Drug Delivery
- EEG and Brain-Computer Interfaces
- Electrospun Nanofibers in Biomedical Applications
- Glioma Diagnosis and Treatment
- RNA Interference and Gene Delivery
- 3D Printing in Biomedical Research
- Nanoplatforms for cancer theranostics
- Neurogenesis and neuroplasticity mechanisms
- Tissue Engineering and Regenerative Medicine
- Extracellular vesicles in disease
- Muscle activation and electromyography studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Immune cells in cancer
- Advanced biosensing and bioanalysis techniques
- Conducting polymers and applications
- Silk-based biomaterials and applications
- Mesenchymal stem cell research
- Spinal Cord Injury Research
- Axon Guidance and Neuronal Signaling
- Neural dynamics and brain function
- Neuroinflammation and Neurodegeneration Mechanisms
- Angiogenesis and VEGF in Cancer
- Proteoglycans and glycosaminoglycans research
Emory University
2007-2025
Duke University
2016-2024
The Wallace H. Coulter Department of Biomedical Engineering
2010-2023
Pratt Institute
2016-2022
Tucker-Davis Technologies (United States)
2021
University of California, Davis
2021
Durham Technical Community College
2021
Georgia Institute of Technology
2009-2018
Indiana University – Purdue University Indianapolis
2018
Purdue University West Lafayette
2018
Abstract This review focuses on the application of nanomaterials for neural interfacing. The junction between nanotechnology and tissues can be particularly worthy scientific attention several reasons: (i) Neural cells are electroactive, electronic properties nanostructures tailored to match charge transport requirements electrical cellular (ii) unique mechanical chemical critical integration with tissue as long‐term implants. (iii) Solutions many problems in biology/medicine limited by...
Prosthetic devices that are controlled by intracortical electrodes recording one's 'thoughts' a reality today, and no longer merely in the realm of science fiction. However, widespread clinical use implanted is hampered lack reliability chronic recordings, independent type used. One major hypothesis has been astroglial scar electrically impedes electrodes. there temporal discrepancy between stabilization scar's electrical properties failure with lagging 1 month. In this study, we test...
Chondroitin sulfate proteoglycans (CSPGs) are a major class of axon growth inhibitors that up-regulated after spinal cord injury (SCI) and contribute to regenerative failure. Chondroitinase ABC (chABC) digests glycosaminoglycan chains on CSPGs can thereby overcome CSPG-mediated inhibition. But chABC loses its enzymatic activity rapidly at 37 °C, necessitating the use repeated injections or local infusions for period days weeks. These infusion systems invasive, infection-prone, clinically...
The ability to successfully interface the brain external electrical systems is important both for fundamental understanding of our nervous system and development neuroprosthetics. Silicon microelectrode arrays offer great promise in realizing this potential. However, when they are implanted into brain, recording sensitivity lost due inflammation astroglial scarring around electrode. scar thought result from acute injury during electrode insertion as well chronic caused by micromotion To...
The goal of this study was to determine if an iodinated, liposomal contrast agent could be used for high-resolution, micro-CT low-contrast, small-size vessels in a murine model.A second-generation, blood pool encapsulating high concentration iodine (83-105 mg I/mL) evaluated. A total five mice weighing between 20 and 28 g were infused with equivalent volume doses (500 microL agent/25 mouse weight) imaged our system intervals up 240 min postinfusion. animals anesthetized, mechanically...
Delivery of chemotherapeutic agents after encapsulation in nanocarriers such as liposomes diminishes side-effects, PEGylated nanocarrier pharmacokinetics decrease dosing to healthy tissues and accumulate tumors due the enhanced permeability retention effect. Once tumor, however, tumor cells is limited potentially by rate release from carriers size-constrained, poor diffusivity interstitium. Here, we report design fabrication a thermosensitive liposomal that maintains its stability with high...
Agarose hydrogel scaffolds were engineered to stimulate and guide neuronal process extension in three dimensions vitro. The extracellular matrix (ECM) protein laminin (LN) was covalently coupled agarose using the bifunctional cross-linking reagent 1,19- carbonyldiimidazole (CDI). Compared unmodified gels, LN-modified gels significantly enhanced neurite from three-dimensionally (3D) cultured embryonic day 9 (E9) chick dorsal root ganglia (DRGs), PC 12 cells. After incubation of DRGs or cells...
Abstract The phenotypic expression of various neural cells is influenced by extracellular matrix (ECM) molecules. This study aims to develop a three‐dimensional gel tailored support neurite extension from cells. Laminin‐derived (LN) oligopeptides CDP‐GYIGSR, 19‐mer IKVAV containing sequence, GRGDSP, cocktail the three aforementioned LN peptides (PEPMIX), and control peptide sequence GGGGG were covalently linked an agarose hydrogel backbone using bi‐functional coupling agent 1′1,...
Neural electrodes could significantly enhance the quality of life for patients with sensory and/or motor deficits as well improve our understanding brain functions. However, long-term electrical connectivity between neural tissue and recording sites is compromised by development astroglial scar around probes. In this study we investigate effect a nanoscale laminin (LN) coating on Si-based probes chronic cortical reaction in rat model. Tissue was evaluated after 1 day, week, 4 weeks...
Abstract Brain tumor invasion leads to recurrence and resistance treatment. Glioma cells invade in distinct patterns, possibly determined by microenvironmental cues including chemokines, structural heterogeneity, fluid flow. We hypothesized that flow originating from pressure differentials between the brain is active glioma invasion. Using vitro models, we show interstitial promotes cell multiple lines. Flow effects were CXCR4-dependent, because they abrogated CXCR4 inhibition. Furthermore,...