A5060384074- Hematopoietic Stem Cell Transplantation
- Mesenchymal stem cell research
- Acute Lymphoblastic Leukemia research
- Cytomegalovirus and herpesvirus research
- Transplantation: Methods and Outcomes
- Polyomavirus and related diseases
- Lysosomal Storage Disorders Research
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Childhood Cancer Survivors' Quality of Life
- Neonatal Respiratory Health Research
- Immunodeficiency and Autoimmune Disorders
- Neurogenesis and neuroplasticity mechanisms
- Blood disorders and treatments
- Virus-based gene therapy research
- CAR-T cell therapy research
- Prenatal Screening and Diagnostics
- Pluripotent Stem Cells Research
- Neutropenia and Cancer Infections
- Neurogenetic and Muscular Disorders Research
- Autism Spectrum Disorder Research
- Neonatal and fetal brain pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Renal Transplantation Outcomes and Treatments
- T-cell and B-cell Immunology
Duke University
2016-2025
Marcus (United States)
2018-2025
Duke University Hospital
2013-2024
Duke Medical Center
2014-2024
Discovery Institute
2024
University Medical Center Utrecht
2023
University of Wisconsin–Madison
2022
Baylor College of Medicine
2020-2022
University of Nebraska Medical Center
2017-2021
Duke Children's Hospital & Health Center
2020
A program for banking, characterizing, and distributing placental blood, also called umbilical-cord transplantation provided grafts 562 patients between August 24, 1992, January 30, 1998. We evaluated this experience.
Transplantation of bone marrow from unrelated donors is limited by a lack HLA-matched and the risk graft-versus-host disease (GVHD). Placental blood sibling can reconstitute hematopoiesis. We report preliminary results transplantation using partially HLA-mismatched placental donors.
Umbilical-cord blood from unrelated donors who are not HLA-identical with the recipients can restore hematopoiesis after myeloablative therapy in children. We studied use of transplantation umbilical-cord to adults.
Original Article from The New England Journal of Medicine — Effect Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor on Hematopoietic Reconstitution after High-Dose Chemotherapy and Autologous Bone Marrow Transplantation
Infantile Krabbe's disease produces progressive neurologic deterioration and death in early childhood. We hypothesized that transplantation of umbilical-cord blood from unrelated donors before the development symptoms would favorably alter natural history among newborns whom was diagnosed because a family history. compared outcomes these with infants who underwent after an untreated cohort affected children.Eleven asymptomatic (age range, 12 to 44 days) 14 symptomatic 142 352 infantile...
PURPOSE We studied high-dose cyclophosphamide, cisplatin, and carmustine (CPA/cDDP/BCNU) with autologous bone marrow support (ABMS) as consolidation after standard-dose adjuvant chemotherapy treatment of primary breast cancer involving 10 or more axillary lymph nodes. PATIENTS AND METHODS One hundred two women stage IIA, IIB, IIIA, IIIB nodes at surgery were registered; 85 eligible, treated, assessable. Patients treated four cycles doxorubicin, fluorouracil (CAF), followed by CPA/cDDP/BCNU...
Hurler's syndrome (the most severe form of mucopolysaccharidosis type I) causes progressive deterioration the central nervous system and death in childhood. Allogeneic bone marrow transplantation before age two years halts disease progression prolongs life, but many children lack a donor. We investigated feasibility using cord-blood transplants from unrelated donors myeloablative preparative regimen that did not involve total-body irradiation young with syndrome.Between December 1995 October...
We treated two children who had adenosine deaminase deficiency and severe combined immunodeficiency disease by injecting bovine modified conjugation with polyethylene glycol. The enzyme was rapidly absorbed after intramuscular injection a half-life in plasma of 48 to 72 hours. Weekly doses approximately 15 U per kilogram body weight maintained activity at three times the level erythrocyte normal subjects. principal biochemical consequences were almost completely reversed. In erythrocytes,...
Data from epidemiological and animal model studies suggest that nutrition during pregnancy may affect the health status of subsequent generations. These transgenerational effects are now being explained by disruptions at level epigenetic machinery. Besides in vitro environmental exposures, possible impact on reprogramming methylation profiles imprinted genes a much earlier time point, such as spermatogenesis or oogenesis, has not previously been considered. In this study, our aim was to...
Several epidemiologic studies have demonstrated associations between periconceptional environmental exposures and health status of the offspring in later life. Although these environmentally related effects been attributed to epigenetic changes, such as DNA methylation shifts at imprinted genes, little is known about potential maternal paternal preconceptional overnutrition or obesity.We examined parental obesity relation profiles multiple human genes important normal growth development, as:...
Preliminary studies using directed-donor ex vivo expanded human mesenchymal stem cells (hMSCs) have shown promise in the treatment of acute graft-versus-host disease (aGVHD). However, their production is cumbersome and standardization difficult. We describe first experience a premanufactured, universal donor, formulation hMSCs (Prochymal) children (n = 12; 10 boys; 9 Caucasian; age range: 0.4-15 years) with treatment-resistant grade III IV aGVHD who received therapy on compassionate use...
Umbilical-cord blood has been used as the source of hematopoietic stem cells in an estimated 30,000 transplants. The limited number a single cord-blood unit prevents its use recipients with larger body mass and results delayed recovery higher mortality. Therefore, we hypothesized that greater numbers two units cord would be associated improved outcomes after transplantation.Between December 1, 2006, February 24, 2012, total 224 patients 1 to 21 years age hematologic cancer were randomly...
Delayed hematopoietic recovery is a major drawback of umbilical cord blood (UCB) transplantation. Transplantation ex vivo-expanded UCB shortens time to recovery, but long-term, robust engraftment by the expanded unit has yet be demonstrated. We tested hypothesis that UCB-derived cell product consisting stem cells for 21 days in presence nicotinamide and noncultured T fraction (NiCord) can accelerate provide long-term engraftment.In phase I trial, 11 adults with hematologic malignancies...
Folic acid (FA) supplementation before and during pregnancy has been associated with decreased risk of neural tube defects although recent reports suggest it may also increase the other chronic diseases. We evaluated exposure to maternal FA in relation aberrant DNA methylation at two differentially methylated regions (DMRs) regulating Insulin-like Growth Factor 2 (IGF2) expression infants. Aberrant these IGF2 deregulation increased susceptibility several Using a self-administered...
Severe steroid-refractory acute graft-versus-host disease (aGVHD) is related to significant mortality and morbidity after allogeneic stem cell transplantation. Early clinical trials of therapy with human mesenchymal cells (hMSCs) in pediatric patients severe aGVHD resistant multiple immunosuppressive agents showed promising results. In this study, we evaluated the risk/benefit profile remestemcel-L (Prochymal), a third-party, off-the-shelf source hMSCs, as rescue agent for...
Allogeneic hematopoietic cell transplantation (allo-HCT) is potentially curative for certain hematologic malignancies and nonmalignant diseases. The field of allo-HCT has witnessed significant advances, including broadening indications transplantation, availability alternative donor sources, less toxic preparative regimens, new manipulation techniques, novel GVHD prevention methods, all which have expanded the applicability procedure. These advances led to clinical practice conundrums when...
Various types of cellular injection have become a popular and costly treatment option for patients with knee osteoarthritis despite paucity literature establishing relative efficacy to each other or corticosteroid injections. Here we aimed identify the safety cell injections from autologous bone marrow aspirate concentrate, adipose stromal vascular fraction allogeneic human umbilical cord tissue-derived mesenchymal cells, in comparison (CSI). The study was phase 2/3, four-arm parallel,...