A5031567548- Multiple Sclerosis Research Studies
- Immunotherapy and Immune Responses
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- T-cell and B-cell Immunology
- Neurobiology of Language and Bilingualism
- Molecular Biology Techniques and Applications
- Mycobacterium research and diagnosis
- Rheumatoid Arthritis Research and Therapies
- Mental Health and Psychiatry
- Delphi Technique in Research
- Orthopedic Infections and Treatments
- Dementia and Cognitive Impairment Research
- Polyomavirus and related diseases
- Systemic Lupus Erythematosus Research
- Cytokine Signaling Pathways and Interactions
- Cytomegalovirus and herpesvirus research
- Psychosomatic Disorders and Their Treatments
- Virus-based gene therapy research
- Transplantation: Methods and Outcomes
Aarhus University Hospital
2009-2025
Aarhus University
2012-2025
Science Research Laboratory
2006
Abstract Background Current proposed criteria for functional cognitive disorder (FCD) have not been externally validated. We sought to analyse the current perspectives of specialists in diagnosis and management FCD comparison with neurodegenerative conditions. Methods International experts disorders were invited assess seven illustrative clinical vignettes containing history bedside characteristics alone. Participants assigned a probable selected appropriate investigation treatment....
Background: In multiple sclerosis (MS), the educational gradient in diagnostic and disease-modifying treatment (DMT) delays is sparsely examined, results are mixed. Objectives: Among patients with relapsing-remitting MS (RRMS), we aimed to examine delay initiation of first DMT. Design: A nationwide cohort study. Methods: We linked Danish Multiple Sclerosis Registry other registries. Diagnostic was evaluated 4344 ⩾20 years at clinical onset from January 1, 2012, onwards, diagnosed by March...
Functional cognitive disorder (FCD) poses a diagnostic challenge due to its resemblance other neurocognitive disorders and limited biomarker accuracy. We aimed develop new checklist identify FCD versus disorders. The clinical was developed through mixed methods: (1) literature review, (2) three-round Delphi study with 45 clinicians from 12 countries (3) pilot discriminative accuracy in consecutive patients attending seven memory services across the UK. Items gathering consensus were...
Quantitative polymerase chain reaction (Q-PCR) studies of urine sediments have demonstrated an increased expression cytotoxin genes during episodes acute rejection renal allografts. To compensate for differences in initial sample size and cDNA preparation, standard Q-PCR experiments involve normalization to a reference gene. Although stable is prerequisite any analysis, commonly used varying across tissues various stimuli. In this study, cellular several was investigated mixed lymphocyte as...
Objectives Epstein–Barr virus (EBV) infection is associated with multiple sclerosis (MS), and EBV may transform lymphoblastoid cell lines more frequently in MS patients than controls, but it not clear whether this reflects a higher viral load or an enhanced ability to reactivate EBV. Material methods controls were examined for their B-cell subsets during 16 weeks spontaneous lymphocyte transforming events. Results had normal distribution of subsets, significantly incidence events, which...
Acute rejection remains an important cause of renal allograft dysfunction and the need for accurate diagnosis is essential to treat transplant recipients successfully. Molecular markers in urine may serve as a diagnostic tool acute rejection, but controversy still exists regarding uniqueness these biomarkers. We measured mRNA perforin (PRF), granzyme B (GZMB) granulysin (GNLY) normalized cyclophilin specimens from 24 with 12 bacteriuria, 11 cytomegalovirus (CMV) infections 17 controls stable...
Background: Teriflunomide has been associated with an increased risk of hypertension. Real-world studies including adequate control groups are lacking. We hypothesized that patients multiple sclerosis (MS) treated teriflunomide would be at higher developing hypertension than those dimethyl fumarate. Methods: conducted a cohort study linking the Danish Multiple Sclerosis Registry national health registries during 10-year period. ( N = 2656) and fumarate 2237) exposure was defined by first...