A5060051584- Multiple Sclerosis Research Studies
- Systemic Sclerosis and Related Diseases
- Polyomavirus and related diseases
- Fungal Plant Pathogen Control
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Inflammatory Bowel Disease
- Cytokine Signaling Pathways and Interactions
- Rheumatoid Arthritis Research and Therapies
- Parkinson's Disease Mechanisms and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Helicobacter pylori-related gastroenterology studies
- SARS-CoV-2 and COVID-19 Research
- Peripheral Neuropathies and Disorders
- Pregnancy and Medication Impact
- Hereditary Neurological Disorders
- Sphingolipid Metabolism and Signaling
- Pharmacological Effects and Toxicity Studies
- Appendicitis Diagnosis and Management
- Mycobacterium research and diagnosis
- Veterinary medicine and infectious diseases
- Infectious Encephalopathies and Encephalitis
- Ovarian cancer diagnosis and treatment
- Spinal Hematomas and Complications
- Powdery Mildew Fungal Diseases
Slagelse Hospital
2019-2024
Region Zealand
2023
Odense University Hospital
2019-2021
Karolinska Institutet
2012-2020
Sygehus Sønderjylland
2019
Aalborg University
2019
Rigshospitalet
2019
Danish Multiple Sclerosis Center
2019
Aarhus University Hospital
2019
University of Southern Denmark
2019
Background and purpose Cardiovascular disease ( CVD ) risk amongst multiple sclerosis MS patients appears raised, but few studies have examined an unselected patient group. course may be relevant for risk. Our aim was to assess variation by in patients. Methods The Multiple Sclerosis Register identified 7667 who received diagnosis between 1964 2005. They were matched age, period, region sex with 76 045 members of the general population without using S wedish registers. Poisson regression...
Patients with multiple sclerosis (MS) and spinal cord injury (SCI) commonly sustain central neuropathic pain (NP) spasticity. Despite a lack of consistent evidence, cannabis-based medicine (CBM) has been suggested as supplement treatment. We aimed to investigate the effect CBM on NP spasticity in patients MS or SCI. performed randomized, double-blinded, placebo-controlled trial Denmark. aged ≥18 years (intensity >3, ≤9 numerical rating scale (NRS0-10) and/or (>3 NRS0-10) were randomized...
<h3>Objective</h3> To compare on-treatment efficacy and discontinuation outcomes in teriflunomide (TFL) dimethyl fumarate (DMF) the treatment of relapsing-remitting multiple sclerosis (RRMS) a real-world setting. <h3>Methods</h3> We identified all patients starting TFL or DMF from Danish Multiple Sclerosis Registry compared between using TFL, adjusted for clinical baseline variables propensity score-based methods. <h3>Results</h3> included 2,236 study: 1,469 on 767 DMF. Annualized relapse...
Background: In multiple sclerosis (MS), the educational gradient in diagnostic and disease-modifying treatment (DMT) delays is sparsely examined, results are mixed. Objectives: Among patients with relapsing-remitting MS (RRMS), we aimed to examine delay initiation of first DMT. Design: A nationwide cohort study. Methods: We linked Danish Multiple Sclerosis Registry other registries. Diagnostic was evaluated 4344 ⩾20 years at clinical onset from January 1, 2012, onwards, diagnosed by March...
Comorbid inflammatory conditions in multiple sclerosis (MS) patients suggest shared risks with MS.To estimate if the risk of immune-mediated disease MS and their parents is increased.Swedish register data were analysed using Cox regression to among 11284 fathers 12006 mothers patients, compared 123158 129409 index subjects without MS. Similar analyses conducted 20276 203951 without.Parents did not have a significantly altered risk. Patients had consistently raised for several diseases:...
Objective Teriflunomide is a once-daily, oral disease-modifying therapy (DMT) for relapsing forms of multiple sclerosis (MS). We studied clinical outcomes in real-world setting involving population-based large cohort unselected patients enrolled The Danish Multiple Sclerosis Registry (DMSR) who started teriflunomide treatment between 2013–2019. Methods This was complete nationwide study with prospectively cases. Demographic and disease-specific patient parameters related to history, efficacy...
A reduced cancer risk amongst patients with multiple sclerosis (MS) has been reported. Theoretically, this could represent a genuine reduction in or, alternatively, 'diagnostic neglect', where is undiagnosed when symptoms are misattributed to MS.Assess all-cause mortality following diagnosis MS compared cohort without MS.A of (n = 19,364) and the general population 192,519) were extracted from national Swedish registers 1969 2005. All-cause after was population. Poisson regression analysis...
Objective To determine if comorbid asthma is associated with accumulation of multiple sclerosis (MS)-related impairment and disability. Method We sent a comprehensive questionnaire to cohort patients MS examined the association between reaching Expanded Disability Status Scale (EDSS) scores 4.0 6.0. Multiple Sclerosis Impact (MSIS-29) were compared without asthma. Results 680 participated in our study whom 88 (12.9%) had There was no difference prevalence England general population (OR:...
Appendicectomy for acute appendicitis, but not other causes, is inversely associated with immune-mediated diseases such as ulcerative colitis, suggesting appendicitis a marker of immune characteristics influencing disease risk. This study investigated the association appendectomy and its underlying diagnosis multiple sclerosis (MS).Swedish general population registers Swedish MS register provided information on 20,542 cases diagnosed between 1964-2006 204,157 controls matched age, sex,...
Rationale: Cognitive dysfunction is a common presenting symptom in patients with HIV/AIDS. It usually directly associated HIV infection or due to opportunistic infection. Rapidly progressive dementia, however, rarely observed acute during immune reconstitution. Recently, case of Creutzfeld-Jakob disease (CJD) has been reported patient chronic The incidence CJD not known be increased among immunocompromised patients. Patient concerns: We here report the 59-year-old male recent diagnosis...
Background: Teriflunomide has been associated with an increased risk of hypertension. Real-world studies including adequate control groups are lacking. We hypothesized that patients multiple sclerosis (MS) treated teriflunomide would be at higher developing hypertension than those dimethyl fumarate. Methods: conducted a cohort study linking the Danish Multiple Sclerosis Registry national health registries during 10-year period. ( N = 2656) and fumarate 2237) exposure was defined by first...
Case reportThe patient and her two children had onset of gastroenteritis (GE) with diarrhea vomiting eight weeks prior to the initial presentation at our emergency room.The GE lasted for 24 hours.The day after GE, began feel a burning sensation on right side scalp as well slight pain in lower back.Two days later, she sought general practitioner nearby community medical center, due lumbar discomfort numbness feet hands.Infection parameters antibodies Lyme disease blood were normal.Due...
Background: Coronavirus in trigeminal nerve (TGN) has for decades been studied as a candidate neurotropic virus associated with multiple sclerosis (MS).The novel coronavirus 2019 (COVID-19) outbreak infected cases is challenging the whole immune system.The lesson from MS treatment and new era of COVID-19 therapies are value to review.Method: Searched databases identify strongest evidence biopsy, autopsy, cerebrospinal fluid (CSF), when using keywords coronavirus, January 1940 April 2020.The...
Objectives:The modern era of multiple sclerosis (MS) biomarkers has been ongoing for many years, with the periodical approval and renewing MS criteria we are still facing challenges.The new revision was recently approved, a few years after McDonald's Criteria, it also followed by promise to find landmarks establishment an diagnosis its courses.An innate immunological clinical sign -which can better connect suspected etiology disease is major interest.Data Sources: A literature search...