A5039237680- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Prion Diseases and Protein Misfolding
- Cholinesterase and Neurodegenerative Diseases
- Peripheral Neuropathies and Disorders
- Neurotransmitter Receptor Influence on Behavior
- Memory and Neural Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Computational Drug Discovery Methods
- Advanced Neuroimaging Techniques and Applications
- Nuclear Receptors and Signaling
- Tryptophan and brain disorders
- Metabolomics and Mass Spectrometry Studies
- Hereditary Neurological Disorders
- Neurological diseases and metabolism
- Urban Planning and Valuation
- Supramolecular Self-Assembly in Materials
- Nerve injury and regeneration
- Advanced X-ray Imaging Techniques
- Neurological Disease Mechanisms and Treatments
- Medicinal Plants and Neuroprotection
- Peripheral Nerve Disorders
- RNA Interference and Gene Delivery
- Advanced MRI Techniques and Applications
Mario Negri Institute for Pharmacological Research
2015-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2015-2025
Azienda Ospedaliera San Gerardo
2021-2025
University of Milano-Bicocca
2019-2024
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
2018
Universitat de Barcelona
2017
Humanitas University
2016
University of Milan
2016
Centro San Giovanni di Dio Fatebenefratelli
2013
Istituto Nazionale di Fisica Nucleare, Sezione di Milano
2011-2013
Inability to form new memories is an early clinical sign of Alzheimer’s disease (AD). There ample evidence that the amyloid-β (Aβ) peptide plays a key role in pathogenesis this disorder. Soluble, bio-derived oligomers Aβ are proposed as mediators synaptic and cognitive dysfunction, but more tractable models Aβ−mediated impairment needed. Here we report that, mice, acute intracerebroventricular injections synthetic 1–42 impaired consolidation long-term recognition memory, whereas mature...
Abstract Neuropeptide Y (NPY) has been implicated in the pathophysiology of certain mood disorders, including depression and anxiety. It is, however, not known which five cloned NPY receptors mediate these functions. We investigated effect Y2 receptor deletion on anxiety stress‐related behaviours. In elevated plus maze, knock out (Y2 −/− ) mice showed a 2.7‐fold higher frequency entering into, spent 3.8 times more time within, open arms compared to controls, while entries into closed did...
A hallmark of Alzheimer disease (AD) is the accumulation amyloid-β (Aβ) peptide in brain. Considerable evidence suggests that soluble Aβ oligomers are responsible for synaptic dysfunction and cognitive deficit observed AD. However, mechanism by which these exert their neurotoxic effect remains unknown. Recently, it was reported bind to cellular prion protein with high affinity. Here, we show N1, main physiological cleavage fragment protein, necessary sufficient binding early oligomeric...
Temporal lobe epilepsy remains amongst the most common and drug refractory of neurological disorders. Gene therapy may provide a realistic therapeutic approach alternative to surgery for intractable focal epilepsies. To test this hypothesis, we applied here gene approach, using recombinant adeno-associated viral (rAAV) vector expressing human neuropeptide Y (NPY) gene, progressive spontaneous seizure model temporal induced by electrical stimulation pole hippocampus, which replicates many...
Alzheimer's disease is characterized by the accumulation and deposition of plaques β-amyloid (Aβ) peptide in brain. Given its pivotal role, new therapies targeting Aβ are demand. We rationally designed liposomes brain promoting disaggregation assemblies evaluated their efficiency reducing burden mouse models. Liposomes were bifunctionalized with a derived from apolipoprotein-E receptor-binding domain for blood–brain barrier phosphatidic acid binding. Bifunctionalized display unique ability...
The multiplicity of systems affected in Alzheimer's disease (AD) brains calls for multi-target therapies. Although mesenchymal stem cells (MSC) are promising candidates, their clinical application is limited because risks related to direct implantation the host. This could be overcome by exploiting paracrine action. We herein demonstrate that vivo systemic administration secretome collected from MSC exposed vitro AD mouse brain homogenates (MSC-CS), fully replicates cell-mediated...
Parkinson's disease and related disorders are devastating neurodegenerative pathologies. Since α-synuclein was identified as a main component of Lewy bodies neurites, efforts have been made to clarify the pathogenic mechanisms α-synuclein's detrimental effects. oligomers most harmful species may recruit activate glial cells. Inflammation is emerging bridge between genetic susceptibility environmental factors co-fostering disease. However, direct evidence linking inflammation activities or...
In the wake of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, an increasing number patients with neurological disorders, including Guillain-Barré (GBS), have been reported following this infection. It remains unclear, however, if these cases are coincidental or not, as most publications were case reports small regional retrospective cohort studies. The International GBS Outcome Study is ongoing prospective observational study enrolling within weeks from onset...
Fatal familial insomnia (FFI) and a genetic form of Creutzfeldt-Jakob disease (CJD178) are clinically different prion disorders linked to the D178N protein (PrP) mutation. The phenotype is determined by 129 M/V polymorphism on mutant allele, which thought influence PrP misfolding, leading formation distinctive strains with specific neurotoxic properties. However, mechanism misfolded variants cause diseases not known. We generated transgenic (Tg) mice expressing mouse homolog FFI These...
Tau is an important protein of the central nervous system formed by 352–441 amino acids and encoded MAPT (microtubule-associated tau) gene on chromosome 17 which generates 6 isoforms. located in axons, dendrites, nucleus, cell membrane, synapses neurons. The also expressed to a lesser extent astrocytes oligodendrocytes, although its role these cells has been little investigated. present interstitial fluid can cross into cerebrospinal (CSF) reach systemic circulation. main function tau...
Alzheimer disease (AD) is characterized by cognitive impairment that starts with memory loss to end in dementia. Loss of synapses and synaptic dysfunction are closely associated AD patients. Biochemical pathological evidence suggests soluble Aβ oligomers correlate impairment. Here, we used the TgCRND8 mouse model investigate role JNK long term deficits. mice were chronically treated cell-penetrating c-Jun N-terminal kinase inhibitor peptide (D-JNKI1). D-JNKI1, preventing action, completely...