A5008412419- Advanced Polymer Synthesis and Characterization
- Block Copolymer Self-Assembly
- Click Chemistry and Applications
- Nanomaterials for catalytic reactions
- biodegradable polymer synthesis and properties
- Alzheimer's disease research and treatments
- Innovative Microfluidic and Catalytic Techniques Innovation
- Supramolecular Self-Assembly in Materials
- Nanoparticle-Based Drug Delivery
- Dendrimers and Hyperbranched Polymers
- Pickering emulsions and particle stabilization
- Chemical Synthesis and Analysis
- Polymer Surface Interaction Studies
- Covalent Organic Framework Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced Drug Delivery Systems
- Cholinesterase and Neurodegenerative Diseases
- Nanocluster Synthesis and Applications
- Nanoporous metals and alloys
- Microfluidic and Capillary Electrophoresis Applications
- Forensic Fingerprint Detection Methods
- Bone Tissue Engineering Materials
- Metal-Organic Frameworks: Synthesis and Applications
- Lipid Membrane Structure and Behavior
- Polymer composites and self-healing
Institut de Chimie et des Matériaux Paris-Est
2015-2024
Centre National de la Recherche Scientifique
2014-2024
Université Paris-Est Créteil
2015-2024
John Wiley & Sons (United Kingdom)
2021
Interface (United Kingdom)
2021
University of East Asia
2021
John Wiley & Sons (United States)
2021
Paris-Est Sup
2015-2018
Universidad Politécnica Estatal del Carchi
2016-2017
Institut de Chimie
2014
Since its discovery, controlled/living radical polymerization (CLRP) has proven to be a mature technology for building tailor-made (block) copolymers, functional polymers and with wide range of biological recognition. Due these considerable advantages over other synthetic approaches, CLRP techniques have been successfully exploited construct novel polymer-protein/peptide bioconjugates high level structural control varied interesting, somehow unexpected, features. A comprehensive review the...
Background: Because of the described hazards related to inhalation manufactured nanoparticles, we investigated lung toxicity biodegradable poly (lactide-co-glycolide) (PLGA) nanoparticles displaying various surface properties on human bronchial Calu-3 cells. Methods: Positively and negatively charged as well neutral were tailored by coating their with chitosan, Poloxamer, or (vinyl alcohol), respectively. Nanoparticles characterized in terms size, zeta potential, chemical composition,...
We have demonstrated that the polyethylene glycol (PEG) corona of long-circulating polymeric nanoparticles (NPs) favors interaction with amyloid-beta (Aβ(1-42)) peptide both in solution and serum. The influence PEGylation poly(alkyl cyanoacrylate) poly(lactic acid) NPs on monomeric soluble oligomeric forms Aβ(1-42) was by capillary electrophoresis, surface plasmon resonance, thioflavin T assay, confocal microscopy, where binding affected aggregation kinetics. capture serum also evidenced...
Abstract The combination of polymeric with biological materials, to create biohybrid macromolecules that merge the properties both natural and synthetic components, is a flourishing area in life sciences biotechnology. click chemistry philosophy has recently provided powerful tool this direction, leading plethora novel, tailor‐made biomacromolecules unprecedented structural characteristics properties. different strategies, using alkyne–azide cycloadditions bioorthogonally achieve coupling...
A versatile and efficient functionalization strategy for polymeric nanoparticles (NPs) has been reported successfully applied to PEGylated, biodegradable poly(alkyl cyanoacrylate) (PACA) nanocarriers. The relevance of this platform was demonstrated in both the fields cancer Alzheimer's disease (AD). Prepared by copper-catalyzed azide–alkyne cycloaddition (CuAAC) subsequent self-assembly aqueous solution amphiphilic copolymers, resulting functionalized NPs exhibited requisite characteristics...
Functional giants: Amphiphilic bioconjugates can be synthesized in situ by grafting polystyrene from a protein (see scheme). The resulting giant amphiphiles display low polydispersities and the characteristic aggregation properties of amphiphilic biomacromolecules. A second, catalytically active guest also included within superstructures.
Despite the wide interest raised by lung administration of nanoparticles (NPs) for treatment various diseases, little information is available on their effect toward airway epithelial barrier function. In this study, potential damage pulmonary epithelium upon exposure to poly(lactide-co-glycolide) (PLGA) NPs has been assessed in vitro using a Calu-3-based model bronchial barrier. Positively and negatively charged as well neutral PLGA were obtained coating surface with chitosan (CS),...
A novel, generic method for the synthesis of families tri-block protein–polymer giant amphiphiles was designed and developed. We have synthesized a hydrophilic α-maleimido poly-1-alkyne with Mn = 9.5 kDa (1H-NMR) narrow PDi (1.15 as measured by SEC) via ATRP (Atom Transfer Radical Polymerization). This polymer succesfully coupled to BSA afford multifunctional bioconjugate which isolated using protein purification techniques fully characterized. Following post-functionalization approach, we...
Solvothermally synthesized oleylamine-coated CoFe<sub>2</sub>O<sub>4</sub>-NPs, exhibiting NMR relaxometric properties, were modified by click chemistry and interacted with cell lines.
Rhodamine B-tagged poly(alkyl cyanoacrylate) amphiphilic copolymers have been synthesised, characterised and successfully used to prepare fluorescent nanoparticles for human brain endothelial cell imaging, allowing their uptake intracellular trafficking be finely observed.
A novel application of capillary electrophoresis with laser-induced fluorescence detection (CE-LIF) was proposed to efficiently detect and monitor the interaction between polymeric nanoparticles β-Amyloid peptide (Aβ1−42), a biomarker for Alzheimer's Disease (AD), at concentrations close physiological conditions. The CE-LIF method allowed PEGylated poly(alkyl cyanoacrylate) (NPs) soluble Aβ1−42 monomers be highlighted. These results were confirmed by surface plasmon resonance (SPR) confocal...
Surface studies of developed fingerprints have aided in the elimination criminal cases before moving to court. The combination X-ray photoelectron spectroscopy (XPS) with aryldiazonium gold(III), 4-O2NC6H4N2+AuCl4-, surface modifier has been shown be a novel approach latent fingerprint detection and development for quantification film elements. robust gold-aryl was on reducing chemicals excreted sebaceous without need external stimuli at lesser extent after contacting free metal surface....
Abstract In this paper, a straightforward method to produce poly(3‐hydroxyalkanoate)‐based multicompartment micelles (MCMs) is presented. Thiol‐ene addition used graft sequentially perfluorooctyl chains and poly(ethylene glycol) oligomers onto poly(3‐hydroxyoctanoate‐ co ‐hydroxyundecenoate) backbone. Well‐defined copolymers are obtained as shown by 1 H NMR size‐exclusion chromatography. After nanoprecipitation in water, novel PHA‐based MCMs evidenced cryo‐transmission electron microscopy....
A novel class of chemically addressable, multifunctional Giant Amphiphiles was synthesized in excellent yields and polydispersity following simultaneous or sequential living radical polymerization the click, copper(I)-catalysed azide–alkyne cycloaddition (CuAAC). This new approach allows chemical tailoring biomacromolecules situ formation nanocontainers.
Thiol-coated nanoporous materials are engineered from polystyrene-<italic>block</italic>-poly(<sc>d</sc>,<sc>l</sc>-lactide) precursors having a disulfide junction. Further adsorption of GNPs on pore surface provides novel supported catalysts.