A5014760544- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Neuroendocrine regulation and behavior
- Memory and Neural Mechanisms
- Nicotinic Acetylcholine Receptors Study
- Pain Mechanisms and Treatments
- Neuroendocrine Tumor Research Advances
- Tryptophan and brain disorders
- Chemokine receptors and signaling
- Neuropeptides and Animal Physiology
- Cannabis and Cannabinoid Research
- Stress Responses and Cortisol
- Pharmacological Receptor Mechanisms and Effects
- Adipose Tissue and Metabolism
- Natural Compound Pharmacology Studies
- Nerve injury and regeneration
- Treatment of Major Depression
- Ion channel regulation and function
- Muscle Physiology and Disorders
- Psychedelics and Drug Studies
- Neuroblastoma Research and Treatments
- Olfactory and Sensory Function Studies
- Eicosanoids and Hypertension Pharmacology
- Lung Cancer Research Studies
Mario Negri Institute for Pharmacological Research
2011-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2013-2021
University of Siena
1999-2003
University of Calabria
2003
University of Salerno
1999
Polish Academy of Sciences
1993
University of Chicago
1984-1986
Abstract Tumor perineural dissemination is a hallmark of human pancreatic ductal adenocarcinoma (PDAC) and represents major source local tumor recurrence after surgery. In this study, we provide in vitro vivo evidence that the chemokine receptor CX3CR1 may be involved neurotropism PDAC cells to peripheral nerves. Neoplastic from cell lines surgical specimens express CX3CR1, absent normal ducts. Its unique ligand, transmembrane CX3CL1, expressed by neurons nerve fibers. + migrated response...
Polymorphism of tryptophan hydroxylase, the rate-limiting enzyme in synthesis brain serotonin (5-HT), is associated with less 5-HT DBA/2J and BALB/c than C57BL/6J 129/Sv mice. We selected forced swimming test, a mouse model used to assess antidepressant potential drugs, neurochemical techniques study strain differences response citalopram, selective reuptake inhibitor. Citalopram reduced immobility time mice but had no such effect The drug accumulation 5-hydroxytryptophan (5-HTP), an...
Physical activity improves the prognosis of cancer patients, partly by contrasting associated muscle wasting (cachexia), through still unknown mechanisms. We asked whether aerobic exercise causes secretion skeletal muscles proteins (myokines) that may contrast cachexia. Media conditioned peroxisome proliferator-activated receptor γ coactivator 1α (PGC1α)-expressing myotubes, reproducing some metabolic adaptations exercise, as increased mitochondrial biogenesis and oxidative phosphorylation,...
Abstract: Experiments were performed to confirm that noradrenergic terminals regulate extracellular concentrations of dopamine (DA) in the frontal cortex rats. The effects 20 mg/kg 1‐[2‐[bis(4‐fluorphenyl)methoxy]‐ethyl]‐4‐(3‐phenylpropyl)piperazine (GBR 12909), a selective inhibitor DA uptake, and 2.5 desipramine (DMI) on striatum studied rats given 6‐hydroxydopamine (6 µg/µl) bilaterally into locus coeruleus destroy terminals. GBR 12909 increased dialysate similarly vehicle...
Dopamine (DA) D3 receptors have been suggested to play a role in mechanisms underlying the ability of drug-associated cues induce drug-seeking behaviour. The present study investigated whether SB-277011-A, selective DA receptor antagonist, modulates reinstatement cocaine-seeking behaviour induced by cocaine-associated stimuli. also explored or not this modulation is generable seeking behaviours associated with nutritive reinforcer such as sucrose. Separate groups rats were trained associate...
Alzheimer disease (AD) is characterized by cognitive impairment that starts with memory loss to end in dementia. Loss of synapses and synaptic dysfunction are closely associated AD patients. Biochemical pathological evidence suggests soluble Aβ oligomers correlate impairment. Here, we used the TgCRND8 mouse model investigate role JNK long term deficits. mice were chronically treated cell-penetrating c-Jun N-terminal kinase inhibitor peptide (D-JNKI1). D-JNKI1, preventing action, completely...
The synthesis, pharmacological evaluation, and structure−activity relationships (SARs) of a series novel pyrroloquinoxalines heteroaromatic-related derivatives are described. new pyrroloquinoxaline-related ligands were tested in rat cortex, tissue expressing high density 5-HT3 receptors, on NG108-15 cells exhibited IC50 values the low nanomolar or subnanomolar range, as measured by inhibition [3H]zacopride binding. SAR studies detailed herein delineated number structural features required...
The synthesis, pharmacological evaluation, and structure−activity relationships (SARs) of a series novel arylalkylpiperazines structurally related to BP897 (3) are described. In binding studies, the new derivatives were tested against panel dopamine, serotonin, noradrenaline receptor subtypes. Focusing mainly on dopamine D3 receptors, SAR studies brought light number structural features required for high affinity selectivity. Several heteroaromatic systems explored their affinities,...
Brain-derived neurotrophic factor (BDNF) dynamic changes were investigated in the medial prefrontal cortex (mPFC) and nucleus accumbens (NAc) during use early phases of cocaine abstinence after 14 sessions (2 h self-administration/d; 0.25 mg/0.1 ml.6 s infusion) by employing a 'yoked control-operant paradigm'. The effect on BDNF was region-specific dependent withdrawal time. In NAc, protein levels increased immediately last self-administration session, with larger increase passively...
Peripheral neuropathy is one of the most frequent and severe complications diabetes. Hydroxytyrosol (HT), major antioxidant polyphenolic compound olive oil, has been investigated as a new potential treatment to counteract progression peripheral diabetic in rats. An established model streptozotocin-induced diabetes used. After confirmation hyperglycemia, nondiabetic animals were randomized receive either low dose or high HT, corresponding vehicle, for 6 weeks. At end 6-week period treatment,...