A5039120460- Cancer Genomics and Diagnostics
- Ovarian cancer diagnosis and treatment
- Genetic factors in colorectal cancer
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Sarcoma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Cancer Cells and Metastasis
- Molecular Biology Techniques and Applications
- Gene expression and cancer classification
- FOXO transcription factor regulation
- Genomic variations and chromosomal abnormalities
- Multiple Myeloma Research and Treatments
- Bioinformatics and Genomic Networks
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- vaccines and immunoinformatics approaches
- T-cell and B-cell Immunology
- Extracellular vesicles in disease
- Protein Degradation and Inhibitors
- Occupational and environmental lung diseases
- Genomics and Rare Diseases
- Blood Pressure and Hypertension Studies
- Chromatin Remodeling and Cancer
IRCCS Humanitas Research Hospital
2022-2025
Mario Negri Institute for Pharmacological Research
2014-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2015-2023
University of Milano-Bicocca
2002-2013
Fondazione Edmund Mach
2013
Radboud University Nijmegen
2010-2012
Radboud University Medical Center
2010-2012
National Taiwan University
2012
Wayne State University
2011
University of Padua
2011
Ovarian cancer (OvC) constitutes significant management challenges primarily due to its late-stage diagnosis and the development of resistance chemotherapy. The standard treatment regimen typically includes carboplatin paclitaxel, with addition poly (ADP-ribose) polymerase inhibitors for patients high-grade serous ovarian (HGSOC) harboring BRCA1/2 mutations. However, variability in responses suggests need investigate factors beyond mutations, such as DNA repair mechanisms epigenetic...
In hypertensive patients, 24-hour blood pressure (BP) variability (V) shows a positive relationship with organ damage, damage progression, and cardiovascular morbidity. The clinical relevance of BPV in the population has never been investigated. sample 3200 individuals, randomly selected from general Monza (Milan, Italy), we evaluated BP by an automatic oscillometric device every 20 minutes for 24 hours left ventricular mass index (LVMI) echocardiography. each subject, individual systolic...
Lurbinectedin is a novel anticancer agent currently undergoing late-stage (Phase II /III) clinical evaluation in platinum-resistant ovarian, BRCA1/2-mutated breast and small-cell lung cancer. structurally related to trabectedin it inhibits active transcription the DNA repair machinery tumour cells.In this study we investigated whether lurbinectedin has ability modulate inflammatory microenvironment viability of myeloid cells tumour-bearing mice.Administration significantly selectively...
Triple-negative breast cancer (TNBC) is an aggressive and heterogeneous subgroup of tumors clinically defined by the lack estrogen, progesterone HER2 receptors, limiting use targeted therapies employed in other malignancies. Recent evidence indicates that c-MYC a key driver TNBC. The BET-bromodomain inhibitor OTX015 (MK-8628) has potent antiproliferative activity accompanied down-regulation several tumor types, demonstrated synergism with mTOR everolimus different models. aim this study was...
Abstract Aberrant microRNA (miR) expression has an important role in tumour progression, but its involvement bone marrow fibroblasts of multiple myeloma patients remains undefined. We demonstrate that a specific miR profile parallels the transition from monoclonal gammopathy undetermined significance (MGUS) to myeloma. Overexpression miR‐27b‐3p and miR‐214‐3p triggers proliferation apoptosis resistance via FBXW7 PTEN/AKT/GSK3 pathways, respectively. Transient transfection inhibitors...
Purpose: Stage I epithelial ovarian cancer (EOC) represents about 10% of all EOCs and is characterized by good prognosis with fewer than 20% patients relapsing. As it occurs less frequently advanced-stage EOC, its molecular features have not been thoroughly investigated. We demonstrated that in stage EOC miR-200c-3p can predict patients' outcome. In the present study, we analyzed expression long non-coding RNAs (lncRNA) to enable potential definition a transcriptional signature prognostic...
Immune synapse formation between dendritic cells (DCs) and T is one of the key events in immune reaction. In immunogenic synapses, presence fully mature DCs mandatory; consequently, modulation DC maturation may promote tolerance represents a valuable therapeutic approach autoimmune diseases. field cell therapy, bone marrow mesenchymal stem (MSCs) have been extensively studied for their immunoregulatory properties, such as inhibiting immunogenicity during vitro differentiation ameliorating...
Clear cell renal carcinoma (RCC) is the most common and invasive adult cancer. For purpose of identifying RCC biomarkers, we investigated chromosomal regions individual genes modulated in pathology. We applied dual strategy assessing integrating genomic transcriptomic data, today considered effective approach for understanding genetic mechanisms cancer sensitive cancer-related genes.We performed first integrated analysis DNA RNA profiles samples using Affymetrix technology. Using 100K SNP...
Epithelial ovarian cancer (EOC) is a spectrum of different diseases, which makes their treatment challenge. Forkhead box M1 (FOXM1) an oncogene aberrantly expressed in many solid cancers including serous EOC, but its role non-serous EOCs remains undefined. We examined FOXM1 expression and correlation to prognosis across the three major EOC subtypes, tumorigenesis chemo-resistance vitro.Gene signatures were generated by microarray for 14 clear-cell 26 endometrioid EOCs, 15 normal endometrium...
Epithelial ovarian cancer (EOC) is one of the most lethal gynecologic diseases, with survival rate virtually unchanged for past 30 years. EOC comprises different histotypes molecular and clinical heterogeneity, but up till now present gold standard platinum-based treatment has been conducted without any patient stratification. The aim study to generate microRNA (miRNA) profiles characteristic each stage I histotype, identify subtype-specific biomarkers improve our understanding underlying...
Microarray technology was used to profile miRNA expression in primary tumor and stromal tissue from paraffin embedded material of 51 patients with colorectal cancer. 26 miRNAs resulted differentially expressed at least 2-fold change respect stroma (16 more the 10 stroma). 10/26 were confirmed as qRTPCR: miR-200c-3p, miR-141-3p, miR-200b-3p, miR-200a-3p, miR-1246, miR-92a-3p, miR-194-5p, miR-192-5p, miR-3651-5p, miR-574-3p. No significant association found between expressions stage diagnosis,...
Physical activity improves the prognosis of cancer patients, partly by contrasting associated muscle wasting (cachexia), through still unknown mechanisms. We asked whether aerobic exercise causes secretion skeletal muscles proteins (myokines) that may contrast cachexia. Media conditioned peroxisome proliferator-activated receptor γ coactivator 1α (PGC1α)-expressing myotubes, reproducing some metabolic adaptations exercise, as increased mitochondrial biogenesis and oxidative phosphorylation,...
High-grade serous epithelial ovarian cancer (HGS-EOC) is defined by high levels of somatic copy-number alterations (SCNA) with marked spatial and temporal tumor heterogeneity. Biomarkers serving to monitor drug response detect disease recurrence are lacking, a fact which reflects an unmet clinical need.A total 185 plasma samples 109 matched biopsies were collected from 46 patients HGS-EOC, analyzed shallow whole-genome sequencing (sWGS). The percentage fraction (TF) in the was used study...
Abstract Wnt signaling is a major driver of stemness and chemoresistance in ovarian cancer, yet the genetic drivers that stimulate its expression remain largely unknown. Unlike other cancers, mutations pathway are not reported high-grade serous cancer (HGSOC). Hence, key challenge must be addressed to develop effective targeted therapies identify nonmutational activation. Using an miRNA sensor-based approach, we have identified miR-181a as novel Wnt/β-catenin signaling. miR-181ahigh primary...