A5102019218- HER2/EGFR in Cancer Research
- Innovation and Knowledge Management
- Angiogenesis and VEGF in Cancer
- Additive Manufacturing and 3D Printing Technologies
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Hemodynamic Monitoring and Therapy
- Quality and Supply Management
- Cancer Treatment and Pharmacology
- Digital Transformation in Industry
- Veterinary Pharmacology and Anesthesia
- Collaboration in agile enterprises
- Product Development and Customization
- Veterinary Medicine and Surgery
- Immune cells in cancer
- Lung Cancer Treatments and Mutations
- Congenital Heart Disease Studies
- Competitive and Knowledge Intelligence
- Frailty in Older Adults
- Fibroblast Growth Factor Research
- Cancer therapeutics and mechanisms
- Reproductive System and Pregnancy
- Cardiovascular and Diving-Related Complications
- Cell death mechanisms and regulation
- Management, Economics, and Public Policy
Ospedale Maria Vittoria
2023
Università Cattolica del Sacro Cuore
2005-2022
University of the Sacred Heart
2016
Presidio Ospedaliero
2009
Azienda Ospedaliero Universitaria San Giovanni Battista
2007
University of Campania "Luigi Vanvitelli"
2006
Novartis (Spain)
2005
Cancer stem cells have been isolated from several solid tumors including prostate, colon, liver, breast, and ovarian cancer. Stem nervous system prostate express CD133 antigen, which is widely used to isolate hematopoietic progenitor cells. The aims of this study were investigate the expression CD133-1 CD133-2 epitopes in primary biologically characterize + cancer cells, also according clinicopathologic parameters. Tissue specimens obtained at surgery 41 carcinomas; eight normal ovaries five...
Purpose The purpose of this paper is to explore the topic customer integration into supply chains. Particular attention focused on literature concerning customer-driven and customer-centric aim provide a deeper understanding these two approaches, clarify differences, compare them conceptual model research propositions, leading theoretical managerial implications. Design/methodology/approach presents systematic review conducted using consolidated methodology. protocol used allows for...
We investigated the association of survivin expression with prognosis and other apoptosis-related biological factors in 110 primary ovarian cancer patients admitted to Division Gynecologic Oncology, Catholic University Rome. Immunohistochemistry was performed on formalin-fixed, paraffin-embedded sections by using polyclonal antibody ab469 for survivin, mouse monoclonal antibodies (clone 124 DO-7), bcl-2 p53, respectively. Cytoplasmic immunoreaction observed 84.5% cases, while nuclear...
Abstract This paper debates the ongoing processes of digital transformation enhanced by 4th industrial revolution in successful companies which have a long time business history and an international presence. The aim is analyzing how what they experienced learned 2nd 3rd revolutions represents key elements that shaped their DNA continue to inspire point gradual radical change concept preferred disruption. Such learning are primary values transfer companies’ order implement it efficiently...
3039 Background: AEE788 is an oral inhibitor with potent activity against multiple tyrosine kinases including EGFR, HER2, and VEGFR2. This phase 1 study was to assess the safety, pharmacokinetics (PK), pharmacodynamics (PD), MTD/DLT dose levels, optimal biologic of AEE788. Methods: Patients (pts) advanced solid tumors were enrolled. Doses escalated in a standard Phase I design 3–6 pts/cohort. Safety monitoring included extensive cardiac assessments. All but pt naïve EGFR VEGF inhibitory...
To our knowledge, very few data about the role of Topoisomerase IIα (TOPO-IIα), an enzyme involved in critical steps tumour cell proliferation and chemoresistance are currently available ovarian cancer patients. The aim this study was to investigate prognostic value TOPO-IIα expression a large, single institution series 96 primary untreated advanced patients admitted Gynecologic Oncology Unit, Catholic University Campobasso Rome. Immunohistochemistry carried out by using MoAb anti-human...
Three-dimensional printing (3DP) is used for multiple purposes in many fields and it attracting attention, both academically managerially, the context of a customer-centric approach to supply chain management. The purpose this paper explore how 3DP enables customer-centricity through value co-creation by analysis case study, manufacture an innovative 3D printed component aerospace sector. research highlights that: 1) usage adoption external orientation drawing on four sources co-creation; 2)...
Three-dimensional printing (3D printing) is one of the customer centric innovations that characterizes new industrial revolution. This innovation has significant implications for many companies in any sector, even most traditional ones. The present study aims to lay foundations increasing and extending knowledge on identify key determinants allow adoption a “customer innovation”, particular 3D printing, by business customers from point view technology provider through conceptual framework....
Three-dimensional printing (3DP) is used for multiple purposes in many fields and it attracting attention, both academically managerially, the context of a customer-centric approach to supply chain management. The purpose this paper explore how 3DP enables customer-centricity through value co-creation by analysis case study, manufacture an innovative 3D printed component aerospace sector. research highlights that: 1) usage adoption external orientation drawing on four sources co-creation; 2)...
In 2020, the global health emergency situation accelerated companies' digital transformation process. Digital channels became a fundamental aspect for managing relationships with their customers and stakeholders, so rethinking of structures channel management requires more in-depth knowledge. This research analyses explores impact in strategies SMEs. The study is conducted on Italian medium-sized enterprises, also known as 'micro-multinationals' or 'pocket multinationals', considering key...
Platypnea-Orthodeoxia Syndrome [POS] is dyspnea and hypoxemia in the upright position that improves supine position. Cardiac POS predominantly caused by congenital interatrial communications [CIC] paired with changes thoracic anatomy, allowing orthostatic right to left cardiac shunting. High suspicion, especially without significant pulmonary disease, does not easily correct supplemental oxygen, should lead clinician obtain echocardiographic imaging, documenting shunting, typically through a...