A5022981599- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Cardiovascular Health and Disease Prevention
- Cardiovascular Function and Risk Factors
- Liver Disease Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
- Nutritional Studies and Diet
- Sodium Intake and Health
- Cardiovascular Disease and Adiposity
- Gout, Hyperuricemia, Uric Acid
- Hemodynamic Monitoring and Therapy
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Hepatitis C virus research
- Alcohol Consumption and Health Effects
- Cerebrovascular and Carotid Artery Diseases
- Heart rate and cardiovascular health
- Liver Disease and Transplantation
- HIV-related health complications and treatments
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular and exercise physiology
- Aortic Disease and Treatment Approaches
- Renal Transplantation Outcomes and Treatments
- COVID-19 Clinical Research Studies
- Aortic aneurysm repair treatments
- Cardiac Health and Mental Health
University of Milano-Bicocca
2016-2025
University of Milan
2016-2022
IRCCS Istituto Auxologico Italiano
2006-2018
Istituti di Ricovero e Cura a Carattere Scientifico
2009-2018
MultiMedica
2009-2017
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
2016-2017
Eastbourne District General Hospital
2016
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2005-2016
Ospedale Maggiore
2005-2016
Azienda Ospedaliera San Gerardo
2008-2015
Background— Studies in hypertensive patients suggest that ambulatory blood pressure (BP) is prognostically superior to office BP. Much less information available the general population, however. Obtaining this was purpose of Pressioni Arteriose Monitorate e Loro Associazioni (PAMELA) study. Methods and Results— Office, home, 24-hour BP values were obtained 2051 subjects between 25 74 years age who representative population Monza (Milan, Italy). Subjects followed up for an average 131 months,...
In the Pressioni Arteriose Monitorate e Loro Associazioni (PAMELA) study, office, home, and ambulatory blood pressure (BP) values were measured contemporaneously between 1990 1993 in a large population sample (n=2051). Cardiovascular (CV) non-CV death certificates collected over next 148 months, which allowed us to assess prognostic value of selective combined elevation these 3 BPs long follow-up. There 69 CV 233 all-cause deaths. Compared with subjects normal office 24-hour BP, hazard ratio...
The hypothesis has been advanced that cardiovascular prognosis is related not only to 24-hour mean blood pressure but also variability. Data, however, are inconsistent, and no long-term prognostic study available. In 2012 individuals randomly selected from the population of Monza (Milan), ambulatory (Spacelabs 90207) was measured via readings spaced by 20 minutes. Systolic diastolic variability obtained calculating following: (1) SD 24-hour, day, night values; (2) day-night difference; (3)...
It is debated whether white-coat (WCHT) and masked hypertension (MHT) are at greater risk of developing a sustained hypertensive state (SHT). In 1412 subjects the Pressioni Arteriose Monitorate e Loro Associazioni Study, we measured office blood pressure (BP), 24-hour ambulatory BP, home BP. The condition WCHT was identified as BP >140/90 mm Hg mean <125/79 or <132/82 Hg. Corresponding values for MHT diagnosis were <140/90 Hg, ≥125/79 ≥132/82 SHT when both means over threshold...
In hypertensive patients, 24-hour blood pressure (BP) variability (V) shows a positive relationship with organ damage, damage progression, and cardiovascular morbidity. The clinical relevance of BPV in the population has never been investigated. sample 3200 individuals, randomly selected from general Monza (Milan, Italy), we evaluated BP by an automatic oscillometric device every 20 minutes for 24 hours left ventricular mass index (LVMI) echocardiography. each subject, individual systolic...
The prevalence of the metabolic syndrome (National Cholesterol Education Program Adult Treatment Panel III criteria) and its relationships with daily life blood pressures, cardiac damage, prognosis were determined in 2013 subjects from a Northern Italian population aged 25 to 74 years. Home pressure, 24-hour left ventricular mass index (echocardiography) also measured. Cardiovascular noncardiovascular deaths registered over 148 months. Metabolic was found 16.2% sample, an office pressure...
Limited information is available on whether and to what extent the different patterns of nocturnal blood pressure profile reported in hypertension are characterized by differences sympathetic drive that may relate to, account for, day-night changes. In 34 untreated middle-aged essential hypertensive dippers, 17 extreme 18 nondippers, 10 reverse we assessed muscle nerve traffic, heart rate, beat-to-beat arterial at rest during baroreceptor deactivation stimulation. Measurements were also...
Previous studies have shown that left ventricular hypertrophy (LVH) represents a cardiovascular risk factor independently of clinic blood pressure (BP). The present study was aimed at determining the impact LVH on incidence morbid and fatal events taking into account not only classical factors but also home ambulatory BP values, which been to an important independent prognostic impact.In 1716 patients belonging 'Pressioni Arteriose Monitorate E Loro Associazioni' population Monza, we...
Background— In high-cardiovascular-risk treated hypertensive patients, the incidence of cardiovascular events has been reported to relate visit-to-visit blood pressure (BP) variability. We investigated whether BP variability is prognostically important in mildly moderately patients whom treatment aims at avoiding but also preventing or delaying progression organ damage. Methods and Results— analyzed pooled data from European Lacidipine Study on Atherosclerosis (ELSA), a randomized,...
The prognostic value of white coat hypertension (WCH) is still debated. In 2051 subjects representative the general population Monza, we measured office, ambulatory, and home blood pressure (BP). risk cardiovascular all-cause mortality was assessed over 16 years in normotensive, sustained hypertensive, WCH subjects, last group being defined as usually done clinical practice (ie, by normality 1 out-of-office [ambulatory or home] BP with an office elevation). Compared normotensive mortality,...
Menopause is commonly associated with some blood pressure (BP) rise, but cross-sectional or longitudinal studies completed so far were often too small and unable to indicate whether this BP increase really dependent on menopause, was caused by age changes in body mass index (BMI).The SIMONA study (Study Hypertension Prevalence the Italian population) a large 18 326 women of range 46-59 years, consecutively seen 302 practitioners all over Italy, representing 60% that National Health care list...
Baseline carotid intima-media thickness (IMT) and plaques are considered predictors of cardiovascular events, but whether they maintain predictive value in treated hypertensive patients time-related (or treatment-induced) IMT changes additional unknown.Analyses were performed the data from European Lacidipine Study on Atherosclerosis (ELSA), a large, randomized, intervention trial which 2334 7 countries followed up under effective antihypertensive treatment for 3.75 years. Kaplan-Meier...
A sustained blood pressure elevation is associated with an increased risk of new-onset diabetes mellitus. Whether this the case also in white-coat and masked hypertension unknown.In 1412 individuals Pressioni Arteriose Monitorate E Loro Associazioni study stratified for sex age decades, we measured office, home 24-h ambulatory together fasting plasma glucose other metabolic variables. This allowed to identify patients white-coat, masked, true normotension.Over a 10-year period, increase...
Objective: To compare the prevalence of metabolic syndrome (MS) in HIV-positive patients with that from a sample general Italian population. Design: Cross-sectional study. Methods: A total 1263 HIV-infected 18 years age or older were recruited centers for infectious diseases northern and central Italy. Controls 2051 subjects aged 25 to 74 representative residents Monza, town Milan province, who enrolled Pressioni Arteriose Monitorate E Loro Associazioni Results: The MS HIV group was 20.8%,...
Obesity is associated with a higher risk of developing diabetes mellitus (DM), hypertension (HT), and left ventricular hypertrophy (LVH). The present study assessed in the general population impact body weight visceral obesity on development alterations glucose metabolism cardiac structure, as well elevation blood pressure. In 1412 subjects randomly selected representative Monza, we twice (in 1990/1991 2000/2001) mass index (BMI); waist circumference; office, home, 24-hour ambulatory...
Recent studies have reported that in patients under antihypertensive treatment visit-to-visit (or long-term) variability of clinic BP within a given patient has an independent prognostic significance. Partly based on between-patient dispersion values during (interindividual variability) it also been long-term is greater for β-blocker than calcium antagonist and other types treatment.To measure intraindividual variations both 24-h mean the hypertensive European Lacidipine Study...
Serum uric acid (SUA) has been associated with an increased cardiovascular risk, but no conclusive evidence exists on whether it is independent risk factor or a reflection of other factors to which related. We examined the relationship SUA number variables [including never evaluated before, such as organ damage and out-of-office blood pressure (BP)], well its prognostic relevance in population.In 2045 participants Pressioni Arteriose Monitorate E Loro Associazioni study, we measured, along...
We estimated the risk of cardiovascular events, mortality, and all-cause mortality associated with left atrium (LA) enlargement alone or combined echocardiographic ventricular hypertrophy (LVH) in 1785 representatives general population Monza recruited for Pressioni Arteriose Monitorate E Loro Associazioni (PAMELA) study. LA was assessed by measuring diameter via echocardiography. defined as a >2.3 cm/m 2 , whereas LVH mass index ≥114 g/m 99 men women, respectively. Death certificates...
It is still largely unknown whether the neuroadrenergic responses to renal denervation (RD) are involved in its blood pressure (BP)–lowering effects and represent predictors of BP RD. In 15 treated true resistant hypertensives, we measured before days, 1, 3, 6 months after RD clinic, ambulatory beat-to-beat BP. Measurements included muscle sympathetic nerve traffic (MSNA), spontaneous baroreflex–MSNA sensitivity, various humoral metabolic variables. Twelve hypertensives served as controls....