A5008608270- Inflammatory Bowel Disease
- Genetic factors in colorectal cancer
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Gastroesophageal reflux and treatments
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Screening and Detection
- Microscopic Colitis
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Colorectal Cancer Surgical Treatments
- Esophageal and GI Pathology
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Esophageal Cancer Research and Treatment
- Angiogenesis and VEGF in Cancer
- Colorectal and Anal Carcinomas
- Diverticular Disease and Complications
- Immune cells in cancer
- Neuropeptides and Animal Physiology
- Chemokine receptors and signaling
- Liver Disease Diagnosis and Treatment
- Digestive system and related health
Vita-Salute San Raffaele University
2022-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2012-2025
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2024-2025
Humanitas University
2014-2023
IRCCS Ospedale San Raffaele
2022-2023
IRCCS Humanitas Research Hospital
2010-2023
University of Milan
2009-2019
Fondazione Humanitas per la Ricerca
2003-2015
Institut thématique Immunologie, inflammation, infectiologie et microbiologie
2014
University Gastroenterology
2014
Tumor-infiltrating T lymphocytes (TIL) play a key role in the clinical outcome of human colorectal cancer; however, dynamics their recruitment along cancer progression have not been fully elucidated. Tertiary lymphoid tissue (TLT) is an ectopic organized lymph node-like structure that typically forms at sites chronic inflammation and involved adaptive immune responses. Its occurrence sporadically documented its relevance largely unknown.The TLT, correlation with TILs, were evaluated...
<b>Background:</b> Cold polypectomy techniques (without electrocautery) by means of biopsy forceps or snare are widely adopted for the removal subcentimetric polyps. However, few data available on safety this approach. The aim study was to assess cold polyps, as well rate advanced neoplasia in these lesions. <b>Patients and methods:</b> In a prospective multicenter trial, consecutive patients with at least one < 10-mm polyp colonoscopy were prospectively included. All polyps detected within...
Patients with early-onset colorectal cancer (eoCRC) are managed according to guidelines that not age-specific. A multidisciplinary international group (DIRECt), composed of 69 experts, was convened develop the first evidence-based consensus recommendations for eoCRC.
The outcome of patients with colorectal cancer is more favorable when the tumor exhibits high-frequency microsatellite instability (MSI). Although associated earlier-stage tumors, MSI has been proposed as an independent predictor survival. We tested prognostic value in a large series diagnosed last decade.The survival 893 consecutive characterized by status was analyzed. 89 (10%) were classified according to mismatch repair (MMR) defect, MMR germ-line mutation, hMLH1 and p16 promoter...
Studies comparing magnetic resonance enterography (MRE) and computerized tomography (CTE) for Crohn's disease (CD) are scarce. The aim of this study was to prospectively compare the sensitivity, specificity, accuracy abdominal MRE CTE assess activity complications (fistulas, strictures) in ileocolonic CD. A total 44 patients (23 male; 21 female; mean age 44) with CD underwent both MR CT a short time interval (mean 5 days). 16-slice intravenous contrast an MRI oral paramagnetic were...
Limited data are available regarding the frequency of oesophageal motility and bolus transit abnormalities in subgroups patients with gastro-oesophageal reflux disease (GERD).To assess endoscopically defined GERD subgroups.Patients (N=755) typical symptoms underwent upper endoscopy, conventional or impedance manometry and/or impedance-pH testing. They were divided into: erosive oesophagitis (EO; N=340), Barrett Oesophagus (BO; N=106), non-erosive (NERD; endoscopy-, abnormal pH SAP/SI+;...
Abstract Tumor perineural dissemination is a hallmark of human pancreatic ductal adenocarcinoma (PDAC) and represents major source local tumor recurrence after surgery. In this study, we provide in vitro vivo evidence that the chemokine receptor CX3CR1 may be involved neurotropism PDAC cells to peripheral nerves. Neoplastic from cell lines surgical specimens express CX3CR1, absent normal ducts. Its unique ligand, transmembrane CX3CL1, expressed by neurons nerve fibers. + migrated response...
BackgroundSince immunomodulators and antitumor necrosis factor (TNF) agents are increasingly used to treat inflammatory bowel disease (IBD), it is recommended administer antipneumococcal vaccination prevent opportunistic pneumonia. There some evidence that concomitant immunosuppression may impair the immune response vaccination. We aimed evaluate rates pneumococcal in four different treatment groups (mesalamine, azathioprine, infliximab, infliximab plus azathioprine).
Inflammatory cells are an essential component of the tumor microenvironment. Neutrophils have emerged as important players in orchestration and effector phase innate adaptive immunity. The significance tumor-associated neutrophils (TAN) colorectal cancer (CRC) has been subject conflicting reports present study was designed to set up a reliable methodology assess TAN infiltration CRC evaluate their clinical significance. CD66b myeloperoxidase (MPO) were assessed candidate neutrophil markers...
Background and aims Inflammatory CC chemokines have long been associated with cancer, but unequivocal evidence of a role in clinically relevant models carcinogenesis is lacking. D6, promiscuous decoy receptor that scavenges inflammatory chemokines, plays non-redundant reducing the response various organs. As inflammation key player development bowel disease (IBD) IBD-associated colorectal we investigated D6 expression human colitis colon its experimental inflammation-associated cancer....
Tumor-associated macrophages (TAMs) play a role in tumor development and progression. We hypothesized that abundance of TAMs might modify efficacy 5-fluorouracil chemotherapy colorectal cancer. measured the density CD68+ at invasive front primary carcinoma (PT-TAMs; n = 208), available matched metastatic lymph node (LN-TAMs; 149), an independent set cancers (PT-TAMs, 111). The hazard ratios for disease-free survival were computed by Cox proportional-hazards model. In exploratory analysis,...