A5064631265- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Nicotinic Acetylcholine Receptors Study
- Receptor Mechanisms and Signaling
- Nerve injury and regeneration
- Tryptophan and brain disorders
- Memory and Neural Mechanisms
- Pain Mechanisms and Treatments
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Cannabis and Cannabinoid Research
- Cytokine Signaling Pathways and Interactions
- Alcoholism and Thiamine Deficiency
- Breastfeeding Practices and Influences
- Anarchism and Radical Politics
- Psychedelics and Drug Studies
- Cardiac Arrest and Resuscitation
- Pharmacogenetics and Drug Metabolism
- Brazilian cultural history and politics
- Colorectal Cancer Screening and Detection
- Youth, Politics, and Society
- Treatment of Major Depression
- Pharmacological Effects and Toxicity Studies
- Forensic Toxicology and Drug Analysis
- Animal Behavior and Welfare Studies
Mario Negri Institute for Pharmacological Research
2009-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2013-2021
Hospital General Universitario Gregorio Marañón
2015
Nerviano Medical Sciences
1995
Abstract: Following administration of 8‐hydroxy‐2‐(di‐ n ‐propylamino)tetralin (8‐OH‐DPAT; 0.04–5.0 μg/0.5 μl) in the raphe nucleus dorsalis (DR) or medianus (MR), synthesis serotonin (5‐HT), as assessed by accumulation 5‐hydroxytryptophan (5‐HTP) after decarboxylase inhibition, was measured various regions rat CNS. At all doses, 8‐OH‐DPAT DR significantly reduced 5‐HTP striatum, accumbens, cortex, and prefrontal whereas even highest dose had no effect hippocampus, hypothalamus, spinal cord....
Brain-derived neurotrophic factor (BDNF) dynamic changes were investigated in the medial prefrontal cortex (mPFC) and nucleus accumbens (NAc) during use early phases of cocaine abstinence after 14 sessions (2 h self-administration/d; 0.25 mg/0.1 ml.6 s infusion) by employing a 'yoked control-operant paradigm'. The effect on BDNF was region-specific dependent withdrawal time. In NAc, protein levels increased immediately last self-administration session, with larger increase passively...
Cardiac arrest (CA) is one of the leading causes death worldwide. Due to hypoxic ischemic brain injury, CA survivors may experience variable degrees neurological dysfunction. This study, for first time, describes progression CA-induced neuropathology in rat. rats displayed and exploratory deficits. Brain MRI revealed cortical striatal edema at 3 days (d), white matter (WM) damage corpus callosum (CC), external capsule (EC), internal (IC) d7 d14. At d3 a significantly correlated with score....
Os resíduos gerados pela população humana têm se tornado uma das principais preocupações ambientais no contexto da sustentabilidade, com ênfase especial nos orgânicos, que representam 50% dos urbanos. Apesar grande quantidade de a coleta adequada é muitas vezes inexistente, o resulta em degradação ambiental. Este estudo foi realizado por meio pesquisa bibliográfica, qualitativa, exploratória e descritiva, analisando artigos científicos sobre compostagem educação ambiental.O presente trabalho...
Chronic self-administration of nicotine induces maladaptive changes in the cortico-accumbal glutamate (Glu) network. Consequently, re-exposure to nicotine-associated cues raises extracellular Glu nucleus accumbens reinstating drug-seeking. Restoring basal concentrations Glu, thereby increasing tonic activation presynaptic group II metabotropic receptors (mGluR2/3) with N-acetylcysteine (N-AC), might offer a valid therapeutic approach for maintaining smoking abstinence. Although N-AC...
Increases in alpha calcium/calmodulin-dependent protein kinase type II (αCaMKII) activity the nucleus accumbens shell has been proposed as a core component motivation to self-administer cocaine and priming-induced drug-seeking. Since withdrawal promotes drug-seeking, we hypothesized that abstinence from self-administration should enhance αCaMKII well.
Electromagnetic field (EMF) technology has the potential to improve scientific data capture and welfare assessment by allowing automated collection from individual cages. However, it is important determine any impact that a new itself may have on animal welfare, previous studies found contrasting results of EMF laboratory rodent anxiety-like behaviour cognition. We therefore investigated whether there was an effect low frequency experienced continuously over six-week period, as integral part...
ABSTRACT Environmental stimuli repeatedly associated with the self‐administered drugs may acquire motivational importance. Because dopamine (DA) D 2 /D 3 partial agonists and antagonists interfere ability of drug‐associated cues to induce drug‐seeking behaviour, present study investigated whether bifeprunox, 7‐[4‐([1,1′biphenyl]‐3‐ylmethyl)‐1‐piperazinyl]‐2(3H)‐benzoxazolone mesylate), a high‐affinity agonist subfamily DA receptors serotonin 1A receptors, influences reinstatement cue‐induced...
Pharmacological stimulation of N-methyl-D-aspartate receptors (NMDAr) could enhance the outcome cue-exposure therapy for smoking cessation. NMDAr can be achieved by increasing pharmacologically synaptic levels glycine, a necessary co-agonist. Here, we evaluate effects SSR504734, selective inhibitor glycine type I transporter (GlyT1) in an extinction-reinstatement procedure inducing robust and lasting nicotine-seeking behavior rats. Male Wistar rats were trained to associate discriminative...
Abstract Previous studies have shown that adolescent exposure to cocaine increases drug use in adulthood, albeit incubation of seeking was found be attenuated rats trained self‐administer during adolescence. We here hypothesize could alter the rewarding properties psychostimulant adulthood. By employing two most widely used animal‐experimental‐preclinical models investigate addiction, we evaluated whether contingent versus non‐contingent self‐administration adolescence modulates its...
4,4'-DMAR is an analogue of the known psychostimulants 4-methylaminorex and aminorex. In light reports deaths associated with its abuse, easy access from Internet vendors, EU Council recently decided on control measures across member states. Here we describe a validated method for measuring plasma levels cis-4,4'-DMAR, crucial preclinical studies analysis in human plasma. Chromatographic separation was done by gradient elution Kinetex C18 column 0.1% formic acid water acetonitrile at 0.2...
Gamma-hydroxybutyric acid (GHB) is an endogenous brain substance that has diverse neuropharmacological actions, including rewarding properties in different animal species and humans. As other drugs of abuse, GHB affects the firing ventral tegmental neurons (VTA) anaesthetized animals hyperpolarizes dopaminergic VTA slices. However, no direct behavioural data on effects applied or target regions its neurons, e.g. nucleus accumbens (NAc), are available. Here, we investigated various doses...
Abstract Nicotine‐associated cues can trigger reinstatement in humans as well animal models of drug addiction. To date, no behavioral intervention or pharmacological treatment has been effective preventing relapse the long term. A large body evidence indicates that N‐acetylcysteine (N‐AC) blunts activation glutamatergic (GLUergic) neurons nucleus accumbens (Nacc) associated with reinstatement. We evaluated effect an experimental cue exposure therapy (eCET) alone combination N‐AC to verify...
<i>para</i>-Methyl-4-methylaminorex (4,4′-DMAR) is a phenethylamine derivative with psychostimulant activity whose abuse has been associated several deaths and wide range of adverse effects. We recently validated high-performance liquid chromatography—tandem mass spectrometry method to measure the compound's concentrations in plasma, we applied it describe pharmacokinetic properties 4,4′-DMAR after single dose rats. In this study, investigated brain disposition metabolism...
No presente artigo, busca-se uma compreensão acerca do pensamento libertário anarquista, explorando suas ideias e práticas a partir meio que entendem como um elemento central para reprodução social: educação. A dessa premissa, são analisadas as principais características ensino instituições criadas de tais teorias, Escola Moderna em Barcelona, destacando o papel transformador educação desempenha na visão anarquista. O trabalho se fundamenta nos escritos autores teóricos movimento libertário,...
We previously demonstrated that nELAV/GAP-43 pathway is pivotal for learning and its hippocampal expression up-regulated by acute stress following repeated cocaine administration. therefore hypothesized abstinence-induced may sustain during early abstinence 2 weeks of self-administration. found contingent, but not non-contingent, exposure selectively increases nELAV, GAP-43, immediately after the last self-administration session, an effect wanes 24 h comes back 7 days later when nELAV...
Introducción: La clasificación NICE permite la diferenciación entre pólipos hiperplásicos y adenomatosos de colon.