A5032401216- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Advanced NMR Techniques and Applications
- Diamond and Carbon-based Materials Research
- Neural dynamics and brain function
- Atomic and Subatomic Physics Research
- Neuroscience and Neuropharmacology Research
- Advanced Neuroimaging Techniques and Applications
- Neurotransmitter Receptor Influence on Behavior
- Complex Network Analysis Techniques
- NMR spectroscopy and applications
- High-pressure geophysics and materials
- RNA Interference and Gene Delivery
- Metal and Thin Film Mechanics
- Memory and Neural Mechanisms
- Laser-induced spectroscopy and plasma
- Laser-Ablation Synthesis of Nanoparticles
- Photoreceptor and optogenetics research
- Receptor Mechanisms and Signaling
- Medical Imaging Techniques and Applications
- Spectroscopy and Quantum Chemical Studies
- Mental Health Research Topics
- Electronic and Structural Properties of Oxides
- Quantum, superfluid, helium dynamics
- Nonlinear Dynamics and Pattern Formation
University of Turin
2019-2025
Center for Sustainable Future Technologies
2021-2024
Italian Institute of Technology
2015-2024
Center for Neuroscience and Cognitive Systems
2014-2024
Cardiff University
2024
Istituto di Fotonica e Nanotecnologie
2022
Politecnico di Milano
2022
National Research Council
2022
University of Trento
2017
Center for Nanotechnology Innovation
2010-2014
Dendrimers have been described as one of the most tunable and therefore potentially applicable nanoparticles both for diagnostics therapy. Recently, in order to realize drug delivery agents, effort has dedicated development dendrimers that could internalize into cells target specific intracellular compartments vitro vivo. Here, we describe cell internalization properties diffusion G4 G4-C12 modified PAMAM primary neuronal cultures CNS live animals. Confocal imaging on neurons reveals are...
The octopus sucker represents a fascinating natural system performing adhesion on different terrains and substrates. Octopuses use suckers to anchor the body substrate or grasp, investigate manipulate objects, just mention few of their functions. Our study focuses morphology mechanism in Octopus vulgaris. We three techniques (MRI, ultrasonography, histology) 3D reconstruction approach contribute knowledge both functionality structure O. results our investigation are two-fold. First, we...
The recent identification of multiple dominant mutations in the gene encoding β-catenin both humans and mice has enabled exploration molecular cellular basis function cognitive impairment. In humans, that cause a spectrum neurodevelopmental disorders have been identified. We identified de novo patients with intellectual disability, carefully characterized their phenotypes, were able to define recognizable disability syndrome. parallel, characterization chemically mutagenized mouse line...
BTBR T+tf/J (BTBR) mice display prominent behavioural deficits analogous to the defining symptoms of autism, a feature that has prompted widespread use model in preclinical autism research. Because neuro-behavioural traits are described with respect reference populations, multiple investigators have examined and behaviour against exhibited by C57BL/6J (B6), mouse line characterised high sociability low self-grooming. In an attempt probe translational relevance this comparison for research,...
Neuroimaging data can be represented as networks of nodes and edges that capture the topological organization brain connectivity. Graph theory provides a general powerful framework to study these their structure at various scales. By way example, community detection methods have been widely applied investigate modular many natural networks, including functional connectivity networks. Sparsification procedures are often remove weakest edges, which most affected by experimental noise, reduce...
By means of optical pumping with laser light it is possible to enhance the nuclear spin polarization gaseous xenon by four five orders magnitude. The enhanced has allowed advances in magnetic resonance (NMR) spectroscopy and imaging (MRI), including transfer molecules lungs other void spaces. A critical issue for such applications delivery sample while maintaining polarization. Described herein an efficient method introduction laser-polarized into systems biological medical interest purpose...
Orexins are neuro-modulatory peptides involved in the control of diverse physiological functions through interaction with two receptors, orexin-1 (OX1R) and orexin-2 (OX2R). Recent evidence pre-clinical models points toward a putative dichotomic role OX2R predominantly regulation sleep/wake cycle arousal, OX1R being more specifically reward processing motivated behaviour. However, specific neural substrates underlying these distinct processes rat brain remain to be elucidated. Here we used...
Here we investigate the cellular uptake mechanism and final intracellular fate of two cationic liposome formulations characterized by similar physicochemical properties but very different lipid composition efficiency for delivery DNA. The first formulation is made 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) zwitterionic helper dioleoylphosphocholine (DOPC), while second one 3β-[N-(N,N-dimethylaminoethane)-carbamoyl] cholesterol (DC-Chol) dioleoylphosphatidylethanolamine (DOPE)....
Antimicrobial peptides (AMPs) are an abundant and wide class of molecules produced by many tissues cell types in a variety mammals, plant animal species. Linear alpha-helical antimicrobial among the most widespread membrane-disruptive AMPs nature, representing particularly successful structural arrangement innate defense. Recently, have received increasing attention as potential therapeutic agents, owing to their broad activity spectrum reduced tendency induce resistance. The introduction...
Graph theory provides a powerful framework to investigate brain functional connectivity networks and their modular organization. However, most graph-based methods suffer from fundamental resolution limit that may have affected previous studies prevented detection of modules, or "communities", are smaller than specific scale. Surprise, resolution-limit-free function rooted in discrete probability theory, has been recently introduced applied networks, revealing wide size-distribution modules...
Abstract The modular organization of brain networks has been widely investigated using graph theoretical approaches. Recently, it demonstrated that partitioning methods based on the maximization global fitness functions, like Newman’s Modularity, suffer from a resolution limit, as they fail to detect modules are smaller than scale determined by size entire network. Here we explore effects this limitation study connectivity networks. We demonstrate limit prevents detection important details...
Autism spectrum disorders (ASD) are neurodevelopmental conditions characterized by pronounced social and communication deficits stereotyped behaviours. Recent psychosocial neuroimaging studies have highlighted reward-processing reduced dopamine (DA) mesolimbic circuit reactivity in ASD patients. However, the neurobiological molecular determinants of these remain undetermined. Mouse models recapitulating ASD-like phenotypes could help generate hypotheses about origin neurophysiological...
Optically enhanced NMR with 129Xe and 3He is emerging as a novel promising technique for medical imaging of lungs other tissues. Here it shown that hyperpolarized provides powerful means measuring blood oxygenation quantitatively noninvasively. The interaction xenon hemoglobin responsible an oxygen-dependent shift in red cells, sharp contrast to the current model xenon–hemoglobin binding. This effect could be exploited brain functional studies, assessment conditions diseases affected by...
The discovery of new highly potent and selective dopamine D3 receptor antagonists has recently permitted characterization the role in a wide range preclinical animal models. A novel series 1,2,4-triazol-3-yl-thiopropyl-tetrahydrobenzazepines demonstrating high level affinity selectivity with an excellent pharmacokinetic profile is reported here. In particular, pyrazolyl derivative 35 showed good oral bioavailability brain penetration associated potency vitro. vivo confirmed that this...