A5061384121- Peripheral Neuropathies and Disorders
- Hereditary Neurological Disorders
- Peripheral Nerve Disorders
- Nerve injury and regeneration
- Myasthenia Gravis and Thymoma
- Orthopedic Surgery and Rehabilitation
- Botulinum Toxin and Related Neurological Disorders
- Neurological disorders and treatments
- Neurogenetic and Muscular Disorders Research
- Transcranial Magnetic Stimulation Studies
- Long-Term Effects of COVID-19
- Genetic Neurodegenerative Diseases
- Pain Mechanisms and Treatments
- Muscle Physiology and Disorders
- Mitochondrial Function and Pathology
- Muscle activation and electromyography studies
- Inflammatory Myopathies and Dermatomyositis
- Cardiomyopathy and Myosin Studies
- Amyotrophic Lateral Sclerosis Research
- Nerve Injury and Rehabilitation
- Motor Control and Adaptation
- Neurology and Historical Studies
- Vestibular and auditory disorders
- Parkinson's Disease Mechanisms and Treatments
- Monoclonal and Polyclonal Antibodies Research
University of Chieti-Pescara
2015-2024
Ospedale SS. Annunziata
1999-2014
Laboratory for Biomedical Neurosciences
2011-2014
Ospedale regionale di Lugano
2011
Ente Ospedaliero Cantonale
2010
Institute of Aging
2009
Foundation University
2009
Foundation University Islamabad
2004-2007
Istituti di Ricovero e Cura a Carattere Scientifico
1997-2006
University of Trieste
2006
Single cases and small series of Guillain-Barré syndrome (GBS) have been reported during the SARS-CoV-2 outbreak worldwide. We evaluated incidence clinical features GBS in a cohort patients from two regions northern Italy with highest number COVID-19.GBS diagnosed 12 referral hospitals Lombardy Veneto March April 2020 were retrospectively collected. As control population, 2019 same considered.Incidence was 0.202/100 000/month (estimated rate 2.43/100 000/year) vs 0.077/100 0.93/100 months...
Abstract Increased titers of antibodies to GM1 ganglioside in humans are associated with lower motor neuron disease and predominantly neuropathy or without conduction block. To investigate the possible mechanism these antibodies, we injected serum a patient anti‐GM1 who had multifocal block, into rat sciatic nerve. When fresh human complement, serum‐induced block temporal dispersion deposits immunoglobulin were detected at nodes Ranvier. Electron microscopic studies revealed demyelination...
Guillain–Barré syndrome is divided into two major subtypes, acute inflammatory demyelinating polyneuropathy and motor axonal neuropathy. The characteristic electrophysiological features of neuropathy are reduced amplitude or absence distal compound muscle action potentials indicating degeneration. In contrast, autopsy study results show early nodal changes in that may produce nerve conduction block. Because the presence block has yet to be fully recognized, we reviewed how often occurred...
<h3>Objective</h3> To electrophysiologically classify an Italian Guillain–Barré syndrome (GBS) population into demyelinating and axonal subtypes, to investigate how serial recordings changed the classification underline pitfalls in electrodiagnosis of GBS subtypes. <h3>Methods</h3> The authors applied two current electrodiagnostic criteria sets for subtypes 55 patients who had at least three motor sensory nerves. <h3>Results</h3> At first test, was almost identical with both criteria: 65–67%...
Whether or not antiganglioside antibodies are related to axonal demyelinating Guillain-Barré syndrome (GBS) is still a matter of controversy, as detailed in previous studies conducted Western and Asian countries.To clarify whether associated with dysfunction Japanese Italian GBS patient cohorts.Clinical electrophysiological profiles were reviewed for 156 patients collected from Japan (n=103) Italy (n=53). Serum IgG against GM1, GM1b, GD1a GalNAc-GD1a measured by ELISA the same laboratory....
Abstract We studied 193 hands of 113 patients referred for typical carpal tunnel syndrome (CTS). Ninety‐five (49%) had normal median distal motor latency (≤4.2 ms) and or borderline sensory conduction velocity from digit 2 stimulation (≥45 m/s). In these cases we performed three to ulnar comparative tests: (1) difference between latencies recorded the second lumbrical interossei muscles (2L‐INT); (2) 4 (D4M‐D4U); (3) mixed nerve palmar (PM‐PU). The 2L‐INT was ≥0.6 ms in 10% hands. PM‐PU...
Because digit 4 (D4) has dual innervation, median and ulnar sensory latencies can be determined over identical distances. To determine if D4 testing is more sensitive than other commonly used techniques to diagnose carpal tunnel syndrome (CTS), we examined 42 hands with clinical evidence of 43 control hands. latency was significantly longer controls often 2 (D2) in patients CTS. Comparing from the most method make diagnosis In mild CTS, a characteristic double peak potential seen recordings...
We studied 169 patients with motor neuron disease. Seventeen showed abnormal amplitude reduction of the compound muscle action potential. Ten had focal loss both and area across a specific segment (conduction block). Eight 10 slowing conduction that segment. Nine were men prominent hand involvement. Six probable or definite upper signs. Five immunologic abnormalities (elevated GM<sub>1</sub> antibody titers paraproteinemia), eight symptoms for more than 4 years. Seven 17 without...
<b><i>Objective:</i></b> To report two patients with an acute exclusively motor neuropathy conduction blocks. <b><i>Methods:</i></b> Serial electrophysiologic studies were carried out. <b><i>Results:</i></b> Two developed symmetric proximal and distal weakness without sensory abnormalities after enteritis. Tendon reflexes normal in one patient brisk the other. One had high titer immunoglobulin G to GD1a GM1, other GD1b, GD1a, GM1 a recent <i>Campylobacter jejuni</i> infection....
Abstract We studied a patient with amyotrophic lateral sclerosis, multifocal motor conduction block, and IgM anti‐GM1 antibodies. A sural nerve biopsy demonstrated deposits of at nodes Ranvier by direct immunofluorescence. The were granular located in the nodal gap between adjacent myelin internodes, some instances, they extended along surface paranodal sheath. When injected into rat sciatic nerve, serum bound to Ranvier, binding activity was removed preincubation GM1. These observations...