A5075642805- Peripheral Neuropathies and Disorders
- Hereditary Neurological Disorders
- Myasthenia Gravis and Thymoma
- Peripheral Nerve Disorders
- Multiple Myeloma Research and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Nerve injury and regeneration
- Pain Mechanisms and Treatments
- Platelet Disorders and Treatments
- Multiple Sclerosis Research Studies
- Amyotrophic Lateral Sclerosis Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Neurogenetic and Muscular Disorders Research
- Cancer Treatment and Pharmacology
- Complement system in diseases
- Vagus Nerve Stimulation Research
- Autoimmune Neurological Disorders and Treatments
- Viral gastroenteritis research and epidemiology
- Histone Deacetylase Inhibitors Research
- Immunodeficiency and Autoimmune Disorders
- Plant-based Medicinal Research
- Blood groups and transfusion
- Circular RNAs in diseases
- Pediatric health and respiratory diseases
- Pituitary Gland Disorders and Treatments
IRCCS Humanitas Research Hospital
2022-2024
University of Milan
2009-2022
Humanitas University
2011-2021
Istituti di Ricovero e Cura a Carattere Scientifico
2007-2021
Foundation Center
2014
Fondazione Istituto Neurologico Nazionale Casimiro Mondino
2014
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2014
University of Pavia
2014
University College London
2014
MRC Mitochondrial Biology Unit
2014
Objectives: We performed responsiveness comparison between the patient-reported Inflammatory Rasch-built Overall Disability Scale (I-RODS) and widely used clinician-reported Neuropathy Cause Treatment–Overall Limitation (INCAT-ONLS) in patients with Guillain-Barré syndrome (GBS), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), immunoglobulin M–monoclonal gammopathy of undetermined significance related polyneuropathy (IgM-MGUSP). Methods: One hundred thirty-seven (GBS: 55,...
<h3>Background</h3> We reported that 6-month therapy with intravenous immunoglobulin (IVIg) was more frequently effective or tolerated than methylprednisolone (IVMP) in patients chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). now retrospectively compared the proportion of who eventually worsened after discontinuing and median time to clinical worsening. <h3>Methods</h3> By March 2013, data were available from 41 45 completing trial a follow-up discontinuation 42 months...
<h3>Background</h3> Increased titres of serum IgM antibodies to GM1 ganglioside are often associated with multifocal motor neuropathy (MMN). Testing for other antigens including GM2, the mixture and galactocerebroside (GM1/GalC) disulfated heparin disaccharide NS6S were reported increase sensitivity antibody testing in MMN even if it is unclear whether specificity positive (PPV) or negative predictive value (NPV) also affected. <h3>Methods</h3> We measured GM1, galactocerebroside, GM1/GalC...
Summary Given its anti‐angiogenic activity, lenalidomide may have a role in the treatment of POEMS ( P eripheral neuropathy, O rganomegaly, E ndocrinopathy, M onoclonal plasma cell disorder and S kin changes) syndrome. This prospective, open‐label, pilot study evaluated combination + dexamethasone RD ) 18 syndrome patients (13 pre‐treated, 5 newly‐diagnosed but ineligible for high‐dose therapy). Treatment consisted six cycles (25 mg/day 21 days followed by 7 rest) plus (40 mg/once week)....
Changes in adenosine receptors and neurotrophic factors the SOD1G93A mouse model of amyotrophic lateral sclerosis: Modulation by chronic caffeine,
Chronic inflammatory demyelinating polyneuropathy (CIDP) can be treated with corticosteroids or intravenous immunoglobulins. Various corticosteroid regimens are currently used in CIDP, but it is unknown whether they equally efficacious. In this retrospective study, we compared efficacy and safety of three CIDP patients. We included treatment naïve patients that fulfilled the EFNS/PNS criteria for CIDP. Patients were according to local protocol expertise centres. Corticosteroid consisted...
Abstract Phosphorylated TDP-43 (pTDP-43) aggregates in the cytoplasm of motor neurons and neuroglia brain are one pathological hallmarks amyotrophic lateral sclerosis. Although axons exceed total volume neuron soma by several orders magnitude, systematic studies investigating presence distribution pTDP-43 within nerves still lacking. The aim this study is to define TDP-43/pTDP-43 pathology diagnostic nerve biopsies performed on a large cohort patients presenting with lower syndrome assess...
Background To evaluate the efficacy of rituximab in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) patients not responding to conventional immune therapies. Methods An open-label, prospective exploratory study was conducted with intravenous on 17 CIDP who had responded at least two first-line The primary endpoint determine proportion showed improvement 6 months after therapy. percentage responders rituximab, along a 95% CI, reported and compared 30% response rate other...
To investigate the molecular defect underlying a large Italian kindred with progressive adult-onset respiratory failure, proximal weakness of upper limbs, and evidence lower motor neuron degeneration.We describe clinical features 5 patients presenting prominent insufficiency, no signs frontotemporal lobar degeneration or semantic dementia. Molecular analysis was performed combining linkage exome sequencing analyses. Further investigations included transcript immunocytochemical protein...
The aim of the present study is to investigate molecular pathways underlying amyotrophic lateral sclerosis (ALS) pathogenesis within peripheral nervous system. We analyzed gene expression changes in human motor nerve diagnostic biopsies obtained from eight ALS patients and seven affected by neuropathy as controls. An integrated transcriptomics system biology approach was employed. identified alterations 815 genes, with 529 up-regulated 286 down-regulated patients. Up-regulated genes...
Background and purpose Anti‐sulfatide immunoglobulin M (IgM) antibodies have been associated with different forms of neuropathies but their diagnostic role in neuropathy remains unclear. Methods The clinical association increased titers anti‐sulfatide IgM 570 patients related disorders examined our laboratory since 2004 was reviewed. Sera were tested by enzyme‐linked immunosorbent assay at the initial serum dilution 1:32 000 titrated serial two‐fold dilution. In all positive to...
Abstract To evaluate the utility of different outcome measures to monitor dose adjustment intravenous immunoglobulin (IVIg) therapy in patients with chronic inflammatory neuropathy (CIN). We assessed IVIg maintenance 20 (10 CIDP and 10 MMN) by regularly monitoring grip strength (GS) using a Martin Vigorimeter, RODS, quality life SF‐36 questionnaire. These were performed patient at home. also extended MRC sumscore (eMRC sumscore) each outpatient visit for infusion. enrolled 30 healthy...
The identification of a distinct subgroup patients within the spectrum lower motor neuron syndromes (LMNS) is crucial as some are potentially treatable. We describe clinical and neuropathological characteristics patient presenting with rapidly progressive LMNS associated high titers anti-GM1 antibodies, leading to respiratory failure 10 months. Histopathological study biopsy obturator nerve branch demonstrated predominantly axonal neuropathy, while electron microscopy analysis localized...
High-dose intravenous immunoglobulin (IVIg) is effective in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and multifocal motor neuropathy (MMN). Not all brands of IVIg are however licensed for these neuropathies. We reviewed six patients with CIDP seven MMN treated maintenance therapy from 2009 to 2013. In patients, we measured the Medical Research Council (MRC) Overall Neuropathy Limitation Scale (ONLS) scores before each infusion, registered monthly dose brand IVIg,...
Anti-sulfatide antibodies have been observed in heterogeneous neuropathies and their clinical relevance is still controversial. Whether the combination of sulfatide with galactocerebroside would increase sensitivity or specificity enzyme-linked immunosorbent assay testing compared to alone was assessed.Immunoglobulin M (IgM) sulfatides, combined (Sulf/GalC) were measured 229 neuropathy patients, including 73 IgM paraproteinemic [62 anti-myelin-associated glycoprotein (anti-MAG) antibody] 156...