A5030256536- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Genetic Neurodegenerative Diseases
- Glycogen Storage Diseases and Myoclonus
- Neuroscience and Neural Engineering
- Transcranial Magnetic Stimulation Studies
- Amyotrophic Lateral Sclerosis Research
- Muscle activation and electromyography studies
- Cerebral Palsy and Movement Disorders
- Surface Chemistry and Catalysis
- Hereditary Neurological Disorders
- Ammonia Synthesis and Nitrogen Reduction
- Neurogenetic and Muscular Disorders Research
- EEG and Brain-Computer Interfaces
- Musicians’ Health and Performance
- Catalytic Cross-Coupling Reactions
- History and advancements in chemistry
- Lysosomal Storage Disorders Research
- Ophthalmology and Eye Disorders
- Neuroscience and Neuropharmacology Research
- Peripheral Neuropathies and Disorders
- Neurological and metabolic disorders
- Motor Control and Adaptation
- Trigeminal Neuralgia and Treatments
Columbia University Irving Medical Center
2007-2023
Columbia University
2009-2021
The Neurological Institute
2008-2016
University Physicians
2012
University of British Columbia
2012
Albert Einstein College of Medicine
2012
University of Manitoba
2012
Icahn School of Medicine at Mount Sinai
2011
Vancouver Biotech (Canada)
2008
University of Minnesota Rochester
2008
Isolated rest tremor, which is observed in some patients with essential tremor (ET), poses a diagnostic challenge. The phenomenon has been examined few studies and poorly understood.To determine the prevalence study clinical correlates of ET to examine electrophysiologic features subgroup patients.Sixty-four cared for at tertiary referral center underwent neurologic examination. Five 12 also quantitative computerized analysis using accelerometry handwritten spiral analysis.Twelve 64 had...
Essential tremor (ET) is the most prevalent movement disorder. It unknown to what extent ET clusters within families, and role of genetic susceptibility in etiology has not been adequately investigated at population level. The problem largely methodological, with few well-designed studies. Washington Heights-lnwood Genetic Study ET, begun 1995, designed investigate genetics using a methodology that applied research date. Part design includes new set clinical electrophysiological diagnostic...
The decision to treat patients with essential tremor (ET) is based primarily on the functional impact of tremor. Correlates disability, apart from severity itself, have not been studied. objective this work was study correlates disability in ET, and present data extent community-dwelling ET cases. cases age-matched control subjects were ascertained a tertiary referral center at Columbia-Presbyterian Medical Center community northern Manhattan, N.Y. Subjects underwent 2.5-hour evaluation,...
To evaluate the safety and efficacy of botulinum toxin type A injection in essential tremor hand.Botulinum is an effective treatment for dystonia, spasticity, other movement disorders has been found to be useful open-label studies one double-masked study hand tremor.One hundred thirty-three patients with were randomized low-dose (50 U) or high-dose (100 (Botox) vehicle placebo treatment. Injections made into wrist flexors extensors. Patients followed 16 weeks. The effect was assessed by...
The present study examined whether premovement central neural processing in Parkinson's disease was related to functional motor disability and plasma L-dopa concentration. Reaction time (RT) performance simple choice RT tasks assessed while levels were controlled by continuous IV infusion five parkinsonian patients. Five age-matched controls performed the same for comparison. Simple patients longer than normal control at all (p less or equal 0.005). However, when "on," but became prolonged...
To investigate the value of objective biomarkers for upper (UMN) and lower (LMN) motor neuron involvement in ALS.We prospectively studied 64 patients with ALS its subsets using clinical measures, proton MR spectroscopic imaging ((1)H MRSI), diffusion tensor imaging, transcranial magnetic stimulation, unit number estimation (MUNE) at baseline every 3 months 15 compared them control subjects.(1)H MRSI measures primary cortex N-acetyl-aspartate (NAA) concentration were markedly reduced (p =...
A new computational method for quantification of tremor and other aspects motor dysfunction is described. By using a digitizing tablet connected to microcomputer, this analysis derived from the handwritten Archimedean spiral. This technique extends standard clinical neurologic test spiral drawing into an objective accurate measure that can automatically detect, characterize, quantify in patients with movement disorders. Further, it safe, inexpensive, fast, portable, noninvasive, be...
Introduction Pre-clinical markers of Parkinson's Disease (PD) are needed, and to be relevant in pre-clinical disease, they should quantifiably abnormal early disease as well. Handwriting is impaired PD can evaluated using computerized analysis drawn spirals, capturing kinematic, dynamic, spatial abnormalities calculating indices that quantify motor performance disability. Digitized spiral drawing correlates with scores may more sensitive detecting changes than subjective ratings. However,...
Until now there has been only one community-based study to examine interethnic differences in the prevalence of essential tremor (ET). The suggested a higher among whites than African Americans. present is first ET Hispanics, Americans, and whites.To estimate (ET) cohort community-dwelling elderly mixed ethnic background.A random sample 2117 Medicare recipients residing Washington Heights-Inwood northern Manhattan, NY, were interviewed. A standardized neurological assessment was performed on...
Early motor experiences have been shown to be important for the development of skills in humans and animals. However, little is known about role experience system development. In this study, we address question whether early shaping corticospinal (CS) tract. We prevented limb use by intramuscular injection botulinum toxin A into selected forelimb muscles produce muscle paralysis during period CS connection specificity, which between postnatal weeks 3 7. terminations were examined using an...
Abstract Spiral analysis is an objective, easy to administer noninvasive test that has been proposed measure motor dysfunction in Parkinson disease (PD). We compared overall Unified Disease Rating Scale Part III scores selected indices derived from spiral seventy‐four patients with early PD (mean duration of 2.4 ± 1.7 years, mean age 61.5 9.7 years). Of the indices, degree severity, first order zero crossing, second smoothness, and speed were best correlated total Parkinson's (UPDRS) score...
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) performed using intraoperative microelectrode recording (MER) to adjust electrode placement has become a widely used treatment for patients with advanced Parkinson disease (PD). Few studies have been conducted examine location implanted electrodes relative intended target, and even fewer undertaken investigate degree which variations in these impacts their clinical efficacy. This study was issues.The authors located 52 bilaterally...
Objective: To develop objective markers for upper motor neuron (UMN) involvement in ALS, the value of single-voxel MR spectroscopy (MRS) and transcranial magnetic stimulation (TMS) was studied.
Tremors are among the most common movement disorders. As there can be considerable variability in manner which clinicians assess tremor, objective quantitative tools such as electromyography, accelerometry, and computerized, spiral analysis very useful establishing a clinical diagnosis research settings.In this review, we discuss various methods of tremor classification pathogenesis tremor. The pathologic tremors an approach to etiology described.Pathologic common, underlying is not always...
<h3>Objective:</h3> To compare the phenotype of primary-appearing dystonia due to variant ataxia-telangiectasia (A-T) with that other ascertained for genetics research. <h3>Methods:</h3> Movement disorder specialists examined 20 Canadian Mennonite adult probands dystonia, as well relatives in 4 families parent-child transmission dystonia. We screened exon 43 c.6200 C>A (p. A2067D) <i>ATM</i> mutation and mutations <i>DYT1</i> <i>DYT6</i>. Clinical features individuals who were harboring...
<strong>Background:</strong> Tremors are among the most common movement disorders. As there can be considerable variability in manner which clinicians assess tremor, objective quantitative tools such as electromyography, accelerometry, and computerized, spiral analysis very useful establishing a clinical diagnosis research settings. <strong>Methods:</strong> In this review, we discuss various methods of tremor classification pathogenesis tremor. The pathologic tremors an approach to etiology...
To determine the dosing, response expectation, efficacy, and most rational strategy for using intramuscular injections of botulinum toxin A (BTX) limb disorders.Open-label prospective analysis outcome after BTX treatment in patients with disorders.Botulinum prepared from lyophilized was injected into selected upper lower muscles under electromyographic guidance. Booster were given every 10 to 14 days during first month (if needed) until optimal effects achieved. Clinical data muscle strength...
Abstract Both postural and kinetic tremors may occur in essential tremor (ET), however the relative contribution of each is not clear. ET has been variably defined with respect to tremors. To examine severity ET, 50 cases from a clinic 55 community underwent videotaped examination. Kinetic were rated using validated clinical rating scale (score range, 0–3). Thirty‐one also accelerometry precisely quantify amplitude. In cases, mean was 1.25 (S.D., 0.89). The 52% higher (1.90; S.D., 0.57; P...
The central factor influencing therapeutic decisions in essential tremor (ET) is the functional impact of tremor. Neither neurological examination nor computerized analysis measures function. Questionnaires may assess function, but data are highly subjective. Performance-based tests impairment provide an alternative means with which to ET.To determine internal consistency and validity a performance-based measure ET.Subjects ET from community northern Manhattan, NY, clinic control subjects...