A5101813829- Cardiac electrophysiology and arrhythmias
- ECG Monitoring and Analysis
- Cardiac Imaging and Diagnostics
- Heart Rate Variability and Autonomic Control
- Cardiovascular Function and Risk Factors
- Effects of Radiation Exposure
- Atrial Fibrillation Management and Outcomes
- Acute Myocardial Infarction Research
- Cardiac Arrhythmias and Treatments
- Immune Response and Inflammation
- interferon and immune responses
- Cardiac pacing and defibrillation studies
- Cardiovascular Effects of Exercise
- Hematopoietic Stem Cell Transplantation
- RNA Research and Splicing
- Immunotherapy and Immune Responses
- Nuclear Structure and Function
- Radioactive contamination and transfer
- Blood Pressure and Hypertension Studies
- Ion channel regulation and function
- Cardiac Structural Anomalies and Repair
- Cancer-related Molecular Pathways
- NF-κB Signaling Pathways
- Parkinson's Disease Mechanisms and Treatments
- Radioactivity and Radon Measurements
Hirosaki University
2016-2025
Shibuya University Network
2025
Kyorin University Hospital
2013-2021
Kyorin University
2005-2019
Juntendo University
1992-2017
RMIT University
2011-2015
Toho University
2012
Hiroshima University
2004
Wakayama Prefectural Tanabe High School
1998
Osaka Prefecture University
1995
Introduction: Autonomic modulation, particularly high vagal tone, plays an important role in the occurrence of ventricular tachyarrhythmias Brugada syndrome. Food intake modulates activity. We assessed usefulness a novel diagnostic technique, “full stomach test,” for identifying high‐risk group patients with Brugada‐type electrocardiogram (ECG). Methods and Results: In 35 ECG, we 12‐lead ECGs before after large meal, pilsicainide pharmacological test, spontaneous ST‐segment change, late...
Background: Recent studies suggest that the Brugada‐type electrocardiogram (ECG) is much more prevalent than manifest Brugada syndrome. Although invasive electrophysiologic investigations have been proposed as a risk stratifier, their value controversial, and alternative noninvasive techniques may be preferred. We sought strategy to detect high‐risk group in long‐term follow‐up study of subjects with ECG, no history cardiac arrest. Methods: This enrolled 124 consecutive ECG. Prognostic...
Background: Occasionally it is difficult to inhibit electrical storm (ES) with standard pharmacological treatment. In the present study effect of landiolol, an ultra-short-acting β1-selective blocker, on ES refractory class III antiarrhythmic drugs was evaluated. Methods and Results: The group comprised 42 consecutive patients who developed for which intravenous drugs, such as amiodarone nifekalant, were ineffective. Landiolol administered intravenously initial dose 2.5 μg · kg–1 min–1,...
Radionuclide concentrations in environmental samples such as surface soils, plants and water were evaluated by high purity germanium detector measurements. The contribution rate of short half-life radionuclides 132I to the exposure dose residents was discussed from measured values. highest values 131I/137Cs activity ratio ranged 49 70 collected at Iwaki City which is located south F1-NPS. On other hand, 132I/131I same had lowest values, ranging 0.01 0.02. By assuming that atmosphere equal...
T-wave alternans based on the modified moving average method (MMA-TWA) and heart rate turbulence (HRT) have been introduced as predictors for cardiac mortality. In this study, we simultaneously recorded MMA-TWA HRT in patients after myocardial infarction (MI) designed a prospective observational study.We prospectively enrolled 313 consecutive post-MI (age 70 ± 12 years, 232 men). The were measured using algorithms 24-h Holter ECG monitoring during daily activity. was determined positive when...
The authors performed linkage analysis in 39 families with autosomal recessive early-onset PD (AR-EOPD) negative for <i><i>parkin</i></i> and <i>DJ-1</i> mutations. Eight including three Japanese, two Taiwanese, one Turkish, Israeli, Philippine showed evidence of PARK6 multipoint log the odds (lod) score 9.88 at D1S2732. results indicate worldwide distribution PARK6-linked parkinsonism.
Late potentials (LP) detected with signal-averaged ECGs are known to be useful in identifying patients at risk of Brugada syndrome (BS) and arrhythmogenic right ventricular cardiomyopathy (ARVC). Because the pathophysiology is clearly different between these disorders, we clarified LP characteristics disorders.This study included 15 BS 12 ARVC 20 healthy controls. All had characteristic ECG changes symptomatic episodes. findings that were consistent recent criteria. Three parameters...
Macrophages are important in the host's immune defense against pathogens. However, recent evidence has demonstrated that macrophages also involved development of disease, including cancer. Therefore, it is to regulate apoptosis tumor‑related for effective cancer treatment. In present study, effect endoplasmic reticulum (ER) stress on induction was examined human monocytic cell‑derived macrophages. Radiation therapy results irradiating as well cells tumor microenvironment. Since ER been...
Abstract Nuclear import, mediated in part by karyopherin-α (KPNA)/importin-α subtypes, regulates transcription factor access to the genome and determines cell fate. However, cancer-specific changes of KPNA subtypes relevancy cancer biology remain largely unknown. Here, we report that KPNA4 , encoding karyopherin-α4 (KPNA4), is exclusively amplified overexpressed head neck squamous carcinoma (HNSCC). Depletion attenuated nuclear localization signal-dependent transport activity suppressed...
Master transcription factors such as TP63 establish super-enhancers (SEs) to drive core transcriptional networks in cancer cells, yet the spatiotemporal regulation of SEs within nucleus remains unknown. The nuclear pore complex (NPC) may tether where RNA export rates are maximal. Here, we report that NUP153, a component NPC, anchors NPC and enhances expression by maximizing mRNA export. This anchoring is mediated through protein-protein interaction between intrinsically disordered regions...
Background: The anticancer activity and radiosensitizing effect of Auranofin, an an-tirheumatic approved gold metallic drug, have been investigated from multiple perspectives. In this study, the action new complex compound TPN-Au(I)-MM4 was compared with that auranofin. Methods: inhibitory 10 μM 50 concentrations on cell proliferation using human colon cancer lines HCT116 SW480. cells evaluated by measuring ability to induce apoptotic death. mechanism qualitatively determined via western...
The relationship between Body Mass Index (BMI) and acute heart failure (HF) remains ill-defined. This study aimed to compare the influence of BMI on in-hospital mortality patients with HF preserved ejection fraction (HFpEF) those reduced (HFrEF) examine specific phenotypes HFpEF/HFrEF according BMI. multicenter retrospective included 5313 6332 consecutive HFpEF HFrEF, respectively. Low, normal, high BMIs were defined as <18.5, 18.5 ≤BMI <25.0, ≥25.0, Overweight/obesity was ≥25.0....
The circadian system influences the pathophysiology of many cardiovascular diseases; however, variations in patients with heart failure preserved ejection fraction (HFpEF) are unknown. Thus, this study aimed to compare clinical characteristics and risk factors for in-hospital mortality between daytime- versus nighttime-onset HFpEF. This multicenter retrospective included 3875 consecutive acute Daytime nighttime periods were defined as 6:00-17:59 18:00-5:59, respectively. Potential prognostic...
It is important to establish an easy-to-use therapeutic protocol for the emergency medical care of patients involved in radiation accidents reduce radiation-related casualties. The present study aimed optimum using currently approved pharmaceutical drugs increase survival victims exposed lethal radiation. Different combinations four drugs-recombinant human erythropoietin (EPO), granulocyte-colony stimulating factor (G-CSF), c-mpl receptor agonist romiplostim (RP) and nandrolone decanoate...
Abstract Toll-like receptors (TLRs) are pattern recognition that recognize pathogen-associated molecular patterns and indispensable for antibacterial antiviral immunity. Our previous report showed ionizing radiation increases the cell surface expressions of TLR2 TLR4 enhances their responses to agonists in human monocytic THP1 cells. The present study investigated how cells treated or not with pharmaceutical agents such as cycloheximide N-acetyl-L-cysteine (NAC) were exposed X-ray...
In the treatment of arrhythmia, β-blockers are mainly used to regulate heart rate. However, also known as drugs with an antiarrhythmic effect due suppression sympathetic activity. We evaluated effects a highly selective β1-blocker, bisoprolol, in patients diurnal paroxysmal atrial fibrillation (P-AF). A total 136 symptomatic P-AF were enrolled. Patients divided into diurnal-specific group and & nocturnal group, well bisoprolol single use combined drug. The 3 categories: subjective symptom...
Background: Few studies have described the clinical usefulness of heart rate turbulence (HRT), an autonomic predictor mortality, in stratifying patients with dilated cardiomyopathy (DCM) at risk cardiac mortality and arrhythmic events. We prospectively assessed utility HRT for stratification ischemic or nonischemic DCM. Methods: enrolled 375 consecutive DCM including (n = 241) causes 134). was measured using algorithm based on routine 24‐hour Holter electrocardiograms, assessing 2...
Background: Intravenous amiodarone (AMD) has been used for the treatment of ventricular tachycardia/fibrillation (VT/VF) in emergency care medicine. However, AMD acts slowly and is occasionally accompanied by hypotension bradycardia. The antiarrhythmic effect intravenous nifekalant (NIF) was assessed patients with VT/VF complicating acute coronary syndrome (ACS) according to our study protocol. Methods Results: Among a series 1,143 ACS patients, 41 who suffered sustained were enrolled; 19...