A5023688808- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- ECG Monitoring and Analysis
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Nutrition and Health in Aging
- Cardiac Imaging and Diagnostics
- Diet and metabolism studies
- Inflammatory Bowel Disease
- Heart Rate Variability and Autonomic Control
- Retinal Diseases and Treatments
- Nutritional Studies and Diet
- Cardiovascular Function and Risk Factors
- Gut microbiota and health
- Glaucoma and retinal disorders
- Reservoir Engineering and Simulation Methods
- Seismic Imaging and Inversion Techniques
- Ion channel regulation and function
- Methane Hydrates and Related Phenomena
- Clinical Nutrition and Gastroenterology
- Retinal and Optic Conditions
- Retinal and Macular Surgery
- Cardiac tumors and thrombi
- Nutrition, Health and Food Behavior
- Pancreatitis Pathology and Treatment
JA Toride Medical Center
2024-2025
St. Marianna University School of Medicine
2017-2025
Meiji (Japan)
2019-2024
Toho University
2007-2023
Urasoe General Hospital
2017-2023
Toho University Medical Center Sakura Hospital
2007-2023
Yokohama City University
2021-2022
Yokohama City University Medical Center
2021
St. Luke's International Hospital
2021
St. Luke's International University
2021
Clinical and animal studies suggested that a medium-chain triglyceride (MCT)-based ketogenic diet provides an alternative energy substrate to the brain has neuroprotective effects, but clinical evidence is still scarce. Here we examined effect of MCT-based formula on cognitive function in patients with Alzheimer's disease (AD). The subjects were 20 Japanese mild-to-moderate AD (11 males, nine females, mean age 73.4 ± 6.0 years) who, separate days, underwent neurocognitive tests 120 min after...
AIM:To evaluate the effectiveness of probiotic therapy for suppressing relapse in patients with inactive ulcerative colitis (UC). METHODS:Bio-Three tablets, each containing 2 mg maintaining clinical remission quiescent UC, especially those who belong to cluster Ⅰ on fecal bacterial analysis.
Low-carbohydrate, high-fat diets (ketogenic diets) might prevent tumor progression and could be used as supportive therapy; however, few studies have addressed the effect of such on colorectal cancer. An infant formula with a ketogenic composition formula; KF) is to treat patients refractory epilepsy. We investigated KF cancer cachexia in colon tumor-bearing mice. Mice were randomized into normal (NR), (TB), (KF) groups. Colon 26 cells inoculated subcutaneously TB The NR groups received...
Introduction: Autonomic modulation, particularly high vagal tone, plays an important role in the occurrence of ventricular tachyarrhythmias Brugada syndrome. Food intake modulates activity. We assessed usefulness a novel diagnostic technique, “full stomach test,” for identifying high‐risk group patients with Brugada‐type electrocardiogram (ECG). Methods and Results: In 35 ECG, we 12‐lead ECGs before after large meal, pilsicainide pharmacological test, spontaneous ST‐segment change, late...
We report two autopsy cases of severe fever with thrombocytopenia syndrome ( SFTS ) a high fatality rate in aged J apanese patients. Both were caused by tick‐bite. The pathognomonic histological feature was necrotizing lymphadenitis systemic lymphoid tissue viruses and SFTSV‐RNA copies. Marked fungal infections also observed the lungs both Since cellular immune function may be suppressed patients, physicians should aware possible infections.
Dark chocolate, rich in polyphenols, increases cerebral blood flow and improves cognitive function. This study aimed to determine whether the consumption of chocolate with a high concentration polyphenols helps maintain performance during cognitively demanding tasks. In this randomized, single-blinded, crossover, dose-comparison study, 18 middle-aged adults consumed two types (25 g each), one (635.0 mg) other low (211.7 cacao performed task requiring response inhibition selective attention...
Objective. Intestinal microflora has been implicated in the etiology of ulcerative colitis (UC). Over past few years, use probiotics UC gained attention. The aim this study was to evaluate efficacy therapy for mild moderate distal refractory conventional therapies. Material and methods. Twenty patients with took 9 BIO-THREE tablets per day 4 weeks. Clinical symptoms endoscopic findings were evaluated as disease activity index (UCDAI) scores before after administration BIO-THREE. Fecal...
Dairy products and fermented foods have a reported association with maintained cognitive function. Camembert cheese, dairy product by the white mold Penicillium camemberti , has also been shown to enhance function in vivo . Oleamide, derived from fermentation of mold, is candidate for an active component, expected improve both sleep conditions. Thus, this study investigated whether milk-based culture (MCW), oleamide, could state clinically. A multi-arm randomized, double-blind,...
A 65-year-old woman aspirated scallop-containing rice porridge, presenting with dyspnea. Computed tomography revealed a foreign body in the right upper bronchus, which was removed using flexible bronchoscopy. Pathology suggested to be scallop adductor muscle fibres. Scallop-related airway bodies are rare, and bronchoscopy is effective.
Transvenous lead extraction (TLE) is a less invasive alternative to surgical removal, but leads may break during TLE. The purpose of this study was compare the tensile strength and behavior under stress from different manufacturers TLE using techniques. Different types (Tendril STS, INGEVITY, INGEVITY+, Solia S, CapSure Fix) were subjected testing machine. tested in up 3 configurations: terminal removed, retained, removal snare. Lead durability assessed by increasing force measuring...
Ketogenic diets, which are carbohydrate-restricted high-fat may have therapeutic effects on various diseases, including cancer. However, ketogenic diets often not standardized and, therefore, results difficult to interpret. We previously investigated the usefulness of in cancer therapy, where formulas (KF) were used as supplements enhance blood ketone bodies; however, amount KF was determined empirically with reference bodies levels. Here, determine a optimal KF, we temporal changes...
Diet modification may contribute to the prevention of age-related cognitive decline. The association between dairy product consumption and function in older people remains unknown. We investigated whether cheese intake is associated with lower (LCF) community-dwelling adults. This cross-sectional study included 1503 adults aged over 65 years. analyzed data were obtained through face-to-face interviews functional ability measurement. Cognitive was assessed using mini-mental state examination...
Evidence suggests that oral intake of medium-chain triglycerides (MCTs), which promote the production ketone bodies, may improve cognitive functions in elderly people; however, underlying brain mechanisms remain elusive. We tested hypothesis improvement accompanies physiological changes and reflects use bodies as an extra energy source. To this end, by using functional magnetic resonance imaging, cerebral blood oxygenation level-dependent (BOLD) signals were measured while 20 healthy...
In the treatment of arrhythmia, β-blockers are mainly used to regulate heart rate. However, also known as drugs with an antiarrhythmic effect due suppression sympathetic activity. We evaluated effects a highly selective β1-blocker, bisoprolol, in patients diurnal paroxysmal atrial fibrillation (P-AF). A total 136 symptomatic P-AF were enrolled. Patients divided into diurnal-specific group and & nocturnal group, well bisoprolol single use combined drug. The 3 categories: subjective symptom...
Cacao polyphenol-enriched dark chocolate may have beneficial effects on human health, such as facilitating maintaining good performance in long-lasting cognitive tasks. This study examined the of intake improving brain function during tasks using functional magnetic resonance imaging (fMRI). In this randomized, single-blinded, crossover, and dose-comparison study, 26 healthy middle-aged participants ingested (25 g) either with a low concentration (LC) (211.7 mg) or high (HC) (635 cacao...
There is ongoing debate as to whether or not α-hydroxyisocaproic acid (HICA) positively regulates skeletal muscle protein synthesis resulting in the gain maintenance of muscle. We investigated effects HICA on mouse C2C12 myotubes under normal conditions and during cachexia induced by co-exposure TNFα IFNγ. The phosphorylation AMPK ERK1/2 was significantly altered 30 min after treatment conditions. basal rates measured a deuterium-labeling method were lowered cachexic Conversely, myotube...