A5052282738- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Mycobacterium research and diagnosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pneumonia and Respiratory Infections
- Neonatal Respiratory Health Research
- Tuberculosis Research and Epidemiology
- Medical Imaging and Pathology Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Restraint-Related Deaths
- Occupational and environmental lung diseases
- Asthma and respiratory diseases
- Cytokine Signaling Pathways and Interactions
- Sarcoidosis and Beryllium Toxicity Research
- Antifungal resistance and susceptibility
- Respiratory Support and Mechanisms
- Lung Cancer Research Studies
- Antibiotic Resistance in Bacteria
- Pleural and Pulmonary Diseases
- Pulmonary Hypertension Research and Treatments
- Respiratory and Cough-Related Research
- Autopsy Techniques and Outcomes
- Genetics, Aging, and Longevity in Model Organisms
Fukuoka University
2016-2025
Fukuoka University Hospital
2016-2025
Toray (United States)
2025
Tohoku University
2015-2024
High Energy Accelerator Research Organization
2024
Waseda University
2024
Shizuoka University
2023-2024
Kyushu University
2005-2023
Edogawa Hospital
2009-2023
Nakanishi (Japan)
2022-2023
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES
Tumor necrosis factor (TNF)-α is a key proinflammatory cytokine that thought to be important in the development of pulmonary fibrosis, whereas its role emphysema has not been as thoroughly documented. In present study, TNF-α was overexpressed alveolar type II cells under control human surfactant protein C promoter. this report, we further characterized abnormalities and provided physiological assessment these mice. Histopathology lungs revealed chronic inflammation, severe air space...
Abstract Transforming growth factor-β1 (TGF-β1) has important roles in lung fibrosis and the potential to induce apoptosis several types of cells. We previously demonstrated that epithelial cells induced by Fas ligation may be involved development pulmonary fibrosis. In this study, we show TGF-β1 induces primary cultured bronchiolar via caspase-3 activation down-regulation cyclin-dependent kinase inhibitor p21. Concentrations were not sufficient alone could enhance agonistic anti-Fas Ab or...
Presence of Mycobacterium fortuitum in respiratory tracts usually indicates mere colonization or transient infection, whereas true pulmonary infection occurs patients with gastroesophageal disease. However, little is known about the diagnostic indications for M. and natural history disease.A 59-year-old man was referred to our hospital treatment against infection. Fifteen years before referral, he underwent total gastrectomy, after which experienced esophageal reflux symptoms. After patient...
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES
Excess of cancer in patients receiving renal transplantation is well-known Western countries, but information Japan remains limited. Our study examined whether excess risk found Japan. Between 1970 and 1995, 1155 males 589 females underwent 6 hospitals, a total 12,982 person-years observation was accumulated. Malignancies developed 2.6% patients; O/E ration 2.78. Median interval from to tumor development 58 months. The the medication with cyclosporine-A (CyA) (median, 42.5 months)...
Three major MAP kinases (MAPKs), including extracellular signal-regulated kinase (ERK), c-jun N-terminal (JNK), and p38 (p38 MAPK), are involved in the regulation of lung inflammation injury. This study investigated whether MAPKs activated associated with injury tissues from patients idiopathic pulmonary fibrosis (IPF). The expression active ERK, JNK, MAPK was examined using western blot analysis immunohistochemistry apoptosis also by TUNEL method, ten IPF obtained thoracoscopic biopsy eight...
Mycobacterium avium complex (MAC) pulmonary disease presents significant therapeutic challenges in respiratory medicine. While amikacin liposome inhalation suspension (ALIS) has emerged as a promising option for treatment-refractory cases, some patients continue to show persistence of infection. We report case 64-year-old male with MAC who demonstrated remarkable clinical response sitafloxacin (STFX) after failing both guideline-based therapy and subsequent ALIS treatment. Although initially...
Tumor necrosis factor-alpha (TNF-alpha) is thought to be important in the development of pulmonary fibrosis. However, surfactant protein-C/TNF-alpha transgenic mice do not spontaneously develop fibrosis but instead alveolar enlargement and loss elastic recoil. We hypothesized that overexpression TNF-alpha lung requires an additional insult produce In this study we evaluated whether altered due bleomycin or transforming growth factor-beta (TGF-beta). Either 0.2 U saline was administered into...
Lung epithelial cells are a primary target for reactive oxygen species (ROS). ROS can cause oxidative deoxyribonucleic acid modification, such as 8-hydroxy-deoxyguanosine (8-OHdG). A human homologue of the MutT protein (hMTH1) prevents this modification. Mitochondria most important cellular source and may be susceptible to damage. The purpose study is investigate stress mitochondrial damage in lung from idiopathic interstitial pneumonias (IIPs). authors analysed 8-OHdG, hMTH1, proteins on...
Istradefylline is a first-in-class, non-dopaminergic, selective adenosine A2A receptor antagonist for the treatment of Parkinson's disease (PD) in patients experiencing wearing-off phenomenon with levodopa (L-DOPA). The authors present an interim report from post-marketing surveillance (PMS) evaluating safety and effectiveness long-term istradefylline real-world setting.Istradefylline was assessed by incidence adverse events (AE) drug reactions (ADRs). Effectiveness using physician's...
Previous work has shown that all-trans-retinoic acid reverses elastase induced emphysema in rats. Since there is currently no effective treatment for pulmonary emphysema, the effect of retinoic should be further investigated other adult species. A study was undertaken using two murine models to evaluate acid.The used were an model acute alveolar destruction and a tumour necrosis factor (TNF)-alpha transgenic mouse which exhibits chronic air space enlargement, loss elastic recoil, increased...
Tumor necrosis factor-α (TNF-α) transgenic mice have previously been found to characteristics consistent with emphysema and severe pulmonary hypertension. Lungs demonstrated alveolar enlargement as well interstitial thickening due chronic inflammation perivascular fibrosis. In the present report, we sought determine potential mechanisms leading development of hypertension in TNF-α mice. To whether sustained vasoconstriction was an important component this hypertension, nitric oxide...
Aims To investigate the histological evolution in development of pleuroparenchymal fibroelastosis ( PPFE ). Methods and results We examined four patients who had undergone surgical lung biopsy twice, or been autopsied, whom diagnosis first was not , but second autopsy . The patterns were cellular fibrotic interstitial pneumonia, pneumonia CIP ) with organizing granulomas acute injury cases 1, 2, 3, 4, respectively. Septal elastosis already present non‐specific pneumonia‐like histology case a...