A5078783207- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- Microbial Natural Products and Biosynthesis
- Nematode management and characterization studies
- Metabolomics and Mass Spectrometry Studies
- Marine and coastal ecosystems
- Biochemical Acid Research Studies
- Gut microbiota and health
- Neuroendocrine regulation and behavior
- Insect and Pesticide Research
- Plant-Microbe Interactions and Immunity
- Tryptophan and brain disorders
- Amphibian and Reptile Biology
- Fungal Biology and Applications
- Microbial Metabolic Engineering and Bioproduction
- Water Quality Monitoring and Analysis
- Mitochondrial Function and Pathology
- Insect-Plant Interactions and Control
- Adenosine and Purinergic Signaling
- Connexins and lens biology
- Plant and animal studies
- Traditional and Medicinal Uses of Annonaceae
- Adipose Tissue and Metabolism
- Insect Utilization and Effects
- Neurobiology and Insect Physiology Research
Cornell University
2016-2025
Ithaca College
2008-2025
Russian Research Institute for Phytopathology
2024
University of Illinois Chicago
2018
Harvard University
2005-2016
GTx (United States)
2016
Helmholtz-Zentrum Hereon
2016
University of Wisconsin–Madison
2012
Max Planck Institute for Developmental Biology
2012
Center for Medical, Agricultural and Veterinary Entomology
2011
The nematode C. elegans is an important model for the study of social behaviors. Recent investigations have shown that a family small molecule signals, ascarosides, controls population density sensing and mating behavior. However, despite extensive studies aggregation behaviors, no intraspecific signals promoting attraction or wild-type hermaphrodites been identified. Using comparative metabolomics, we show known ascarosides are accompanied by series derivatives featuring tryptophan-derived...
Abstract Plant-defense responses are triggered by perception of conserved microbe-associated molecular patterns (MAMPs), for example, flagellin or peptidoglycan. However, it remained unknown whether plants can detect derived from plant-parasitic animals, including nematodes. Here we show that several genera nematodes produce small molecules called ascarosides, an evolutionarily family nematode pheromones. Picomolar to micromolar concentrations ascr#18, the major ascaroside in nematodes,...
The ≈80-kb pksX gene cluster in Bacillus subtilis encodes an unusual hybrid polyketide/nonribosomal peptide synthase that has been linked to the production of uncharacterized antibiotic bacillaene. Multiple copies this synthase, each similar size ribosome, assemble into a single organelle-like complex with mass tens hundreds megadaltons. resource requirements assembled megacomplex suggest bacillaene important biological role. By coupling differential NMR spectroscopic technique genetically...
Summary The cleavage of glucosinolates by myrosinase to produce toxic breakdown products is a characteristic insect defense cruciferous plants. Although green peach aphids ( Myzus persicae ) are able avoid most contact with when feeding from the phloem Arabidopsis thaliana , indole nevertheless degraded during passage through insects. A defensive role for suggested observation that atr1D mutant plants, which overproduce glucosinolates, more resistant M. whereas cyp79B2 cyp79B3 double...
Small molecule metabolites play important roles in Caenorhabditis elegans biology, but effective approaches for identifying their chemical structures are lacking. Recent studies revealed that a family of glycosides, the ascarosides, differentially regulate C. development and behavior. Low concentrations ascarosides attract males thus appear to be part sex pheromone, whereas higher induce developmental arrest at dauer stage, an alternative, nonaging larval stage. The act synergistically,...
Given worldwide increases in the incidence of obesity and type 2 diabetes, new strategies for preventing treating metabolic diseases are needed. The nuclear receptor PPARγ (peroxisome proliferator-activated gamma) plays a central role lipid glucose metabolism; however, current PPARγ-targeting drugs characterized by undesirable side effects. Natural products from edible biomaterial provide structurally diverse resource to alleviate complex disorders via tailored nutritional intervention. We...
In the model organism Caenorhabditis elegans, a family of endogenous small molecules, ascarosides function as key regulators developmental timing and behavior that act upstream conserved signaling pathways. The are based on dideoxysugar ascarylose, which is linked to fatty-acid-like side chains varying lengths derived from peroxisomal β-oxidation. Despite importance for many aspects C. elegans biology, knowledge their structures, biosynthesis, homeostasis remains incomplete. We used an...
Fine fescue grasses displace neighboring plants by depositing large quantities of an aqueous phytotoxic root exudate in the soil rhizosphere. Via activity-guided fractionation, we have isolated and identified nonprotein amino acid m-tyrosine as major active component. m-Tyrosine is significantly more than its structural isomers o- p-tyrosine. We show that exposure results growth inhibition for a wide range plant species propose release this interferes with development competing plants. Acid...
Battle of the Sexes In many species, males compete with one another to propagate their own DNA, often detriment females (see Perspective by Promislow and Kaeberlein ). Shi Murphy (p. 536 , published online 19 December) discovered that mating in Caenorhabditis species causes mothers shrink die soon after they have ceased producing progeny. Males appear hijack longevity stress resistance pathways normally employed slow reproduction somatic aging times stress. Maures et al. 541 29 November)...
Small molecules are central to biology, mediating critical phenomena such as metabolism, signal transduction, mating attraction, and chemical defense. The traditional categories that define small molecules, metabolite, secondary pheromone, hormone, so forth, often overlap, a single compound can appear under more than one functional heading. Therefore, we favor unifying term, biogenic (BSMs), describe any molecule from biological source. In similar vein, two major fields of research,natural...
Anthelmintic resistance has become a global phenomenon in gastro-intestinal nematodes of farm animals, including multi-drug against the three major classes anthelmintics. There is an urgent need for anthelmintic with new mode action. The recently discovered amino-acetonitrile derivatives (AADs) offer class synthetic chemicals activity. evaluation AADs was pursued applying vitro assays and efficacy tolerability studies rodents, sheep, cattle. Amongst various suitable compounds, AAD 1566...