A5084794955- Natural product bioactivities and synthesis
- Marine Sponges and Natural Products
- Microbial Natural Products and Biosynthesis
- Aquaculture Nutrition and Growth
- Traditional and Medicinal Uses of Annonaceae
- Bioactive Compounds and Antitumor Agents
- Biochemical and Structural Characterization
- Organic Chemistry Synthesis Methods
- Tryptophan and brain disorders
- Ginseng Biological Effects and Applications
- IL-33, ST2, and ILC Pathways
- Cell death mechanisms and regulation
- Traditional Chinese Medicine Analysis
- Gut microbiota and health
- Eosinophilic Esophagitis
- Phytochemistry and Biological Activities
- Synthesis and bioactivity of alkaloids
- Plant-Microbe Interactions and Immunity
- Food and Agricultural Sciences
- Plant biochemistry and biosynthesis
- Medicinal Plants and Neuroprotection
- Bioactive natural compounds
- Garlic and Onion Studies
- Nitrogen and Sulfur Effects on Brassica
- Vanadium and Halogenation Chemistry
Cornell University
2018-2024
Seoul National University
2012-2021
University of California, Davis
1989
Innate lymphoid cells (ILCs) can promote host defense, chronic inflammation, or tissue protection and are regulated by cytokines neuropeptides. However, their regulation diet microbiota-derived signals remains unclear. We show that an inulin fiber promotes Tph1-expressing inflammatory ILC2s (ILC2INFLAM) in the colon, which produce IL-5 but not tissue-protective amphiregulin (AREG), resulting accumulation of eosinophils. This exacerbates inflammation a murine model intestinal damage ILC2-...
ABSTRACT Microbial secondary metabolites, including isocyanide moieties, have been extensively mined for their repertoire of bioactive properties. Although the first naturally occurring (xanthocillin) was isolated from fungus Penicillium notatum over half a century ago, biosynthetic origins fungal isocyanides remain unknown. Here we report identification family synthases (ICSs) opportunistic human pathogen Aspergillus fumigatus . Comparative metabolomics overexpression or knockout mutants...
The maintenance of sufficient but nontoxic pools metal micronutrients is accomplished through diverse homeostasis mechanisms in fungi. Siderophores play a well established role for iron homeostasis; however, no copper-binding analogs have been found Here we demonstrate that, Aspergillus fumigatus, xanthocillin and other isocyanides derived from the xan biosynthetic gene cluster (BGC) bind copper, impact cellular copper content, significant metal-dependent antimicrobial properties....
Twenty-four metabolites, including seven new compounds (1–7), were isolated from the dried fruits of Psoralea corylifolia. On basis combined spectroscopic and chemical analysis, determined to be six flavonoids (1–6) a meroterpenoid (7). The absolute configurations natural products obtained, previously undetermined 16 17, assigned by several methods, such as NOE spectroscopy, optical rotation, CD spectroscopy. Several these exhibited moderate inhibitory activity toward Staphylococcus...
Nine new compounds, tris-aromatic furanones (1, 2, 3a, 3b, and 4) related bis-aromatic diesters (5a, 5b, 6a, 6b), are described from the ascidian Synoicum sp. collected off coast of Chuja-do, Korea. The structures these designated as cadiolides E G–I (1–4) synoilides A B (5 6), were determined by extensive spectroscopic analyses. absolute configuration at asymmetric center cadiolide G (2) was assigned ECD analysis. Of I possess unprecedented carbon skeletons. Several compounds exhibited...
Five new manzamine alkaloids (1–5) and salt forms of two known manzamines (6 7), along with seven compounds (8–14) the same structural class, were isolated from an Indonesian Acanthostrongylophora sp. sponge. On basis results combined spectroscopic analyses, structure kepulauamine A (1) was determined to possess unprecedented pyrrolizine moiety, while others functional group variants manzamines. These exhibited weak cytotoxicity, moderate antibacterial activity, mild inhibition against...
Abstract Tumor heterogeneity is associated with the therapeutic failures of targeted therapies. To overcome such heterogeneity, a novel therapy proposed that could kill tumor populations diverse phenotypes by delivering nonselective cytotoxins to target‐positive cells as well surrounding via recurrent bystander killing effect. A representative prodrug prepared targets integrin αvβ3 and releases upon entering or caspase‐3. This allows αvβ3‐positive upregulate caspase‐3, which in turn,...
Abstract The genomes of many filamentous fungi, such as Aspergillus spp., include diverse biosynthetic gene clusters unknown function. We previously showed that low copper levels upregulate a cluster includes crmA , encoding putative isocyanide synthase. Here we show, using untargeted comparative metabolomics, CrmA generates valine-derived contributes to two distinct pathways under copper-limiting conditions. Reaction the with an ergot alkaloid precursor results in carbon-carbon bond...
Asperphenins A (1) and B (2), novel diastereomeric lipopeptidyl benzophenone metabolites, were isolated from a marine-derived Aspergillus sp. fungus. On the basis of results combined spectroscopic analyses, structures these compounds determined to be linear assemblies three motifs: hydroxy fatty acid, tripeptide, trihydroxybenzophenone. The absolute configurations assigned using chemical modifications electronic circular dichroism (ECD) calculations. exhibited significant cytotoxicity on...
Panax ginseng C.A. MEYER is one of the most popular medicinal herbs in Asia and chemical constituents are changed by processing methods such as steaming or sun drying. Metabolomic analysis was performed to distinguish age discrimination four- six-year-old red using ultra-performance liquid chromatography quadruple time flight mass spectrometry (UPLC-QToF-MS) with multivariate statistical analysis. Principal component (PCA) showed clear between extracts different ages suggest totally six...
Isocadiolides A-H (1-8) and cadiolide N (9), new polybrominated aromatic compounds, were isolated from a Korean Synoicum sp. ascidian. On the basis of results extensive spectroscopic analyses, these compounds possessed tris-bromohydroxyphenyl moieties as common structural motif, while their cores varied [cyclopentenedione (1-5), dihydrofuran (6 7), pyranone (8), furanone (9)], reflecting different extents rearrangement oxidation. Several exhibited weak antibacterial activities moderate...
The characteristic odors of freshly macerated tissue Allium species such as garlic and onion are due to the action enzyme alliin lyase (EC 4.4.1.4) on endogenous S‐alkyl‐I‐cysteine sulfoxides which present secondary amino acids yielding volatile sulfur‐containing products. Purification characterization leek ( porrum L.) has been carried out for comparison with analogous enzymes previously characterized from onion. purification involved homogenization, followed by ammonium sulfate...
Psammocindoles A–C (1–3), a new class of indole alkaloids, were isolated from Psammocinia vermis sponge. By combined spectroscopic analyses, the structures these compounds determined to be indole-γ-lactams derived three amino acid residues. In addition, an enantiomer psammocindole D (4), and N-lactam isomers isopsammocindoles A–D (5–8) also synthesized. These natural products synthetic analogues found significantly stimulate adiponectin secretion in human bone marrow mesenchymal stem cells.
A method based on HPLC coupled with an evaporative light scattering detection and ESI quadrupole TOF MS was established for the quantification identification of phenolics triterpene saponins in Kalopanacis Cortex using a gradient elution acetonitrile 0.1% formic acid water RP C18 column (4.6 × 250 mm, 5 μm). Diverse validation parameters, such as linearity, LOD LOQ, accuracy, precision, repeatability, stability, were successfully obtained. Additionally, efficiencies different extraction...