A5083009228- Lipoproteins and Cardiovascular Health
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Peripheral Artery Disease Management
- Atherosclerosis and Cardiovascular Diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- Angiogenesis and VEGF in Cancer
- Cardiac Structural Anomalies and Repair
- Heart Failure Treatment and Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Cardiac Arrest and Resuscitation
- Cardiovascular Disease and Adiposity
- Cancer, Lipids, and Metabolism
- Cardiomyopathy and Myosin Studies
- Atrial Fibrillation Management and Outcomes
- Adipokines, Inflammation, and Metabolic Diseases
- Blood Pressure and Hypertension Studies
- Electrolyte and hormonal disorders
- Lymphatic System and Diseases
- Abdominal vascular conditions and treatments
Kyoto Prefectural University of Medicine
2020-2025
Matsushita Memorial Hospital
2017-2024
Nihon University
2005-2016
Surugadai Nihon University Hospital
2004-2013
Background: Basic fibroblast growth factor (bFGF) is an angiogenic with a short half-life. Because recombinant bFGF in clinical use, we hypothesized that the localization of atelocollagen would have effects at injection site normal and hind limb ischemic animal models.
Acute mesenteric ischemia is rare, and few large-scale trials have evaluated endovascular therapy (EVT) open surgical revascularization (OS). This study aimed to assess clinical outcomes after EVT or OS for acute superior artery occlusion identify predictors of mortality bowel resection.
Previous studies have reported the efficacy and safety of therapeutic angiogenesis through bone marrow-derived mononuclear cell (BM-MNC) implantation in patients with no-option chronic limb-threatening ischemia (CLTI) from atherosclerotic lower extremity artery disease (LEAD). However, uncertain clinical prognostic factors impact treatment outcomes. This study aimed to elucidate long-term outcomes LEAD-derived CLTI after BM-MNC identify factors.In this retrospective, single-center,...
Background: The purpose of this study was to explore the effect lifestyle modification, mainly daily aerobic exercise, on coronary atherosclerosis in patients with artery disease (CAD). Methods and Results: A 6-month prospective observational conducted 84 CAD receiving pravastatin treatment order evaluate relationship between particular plaque volume as assessed by intravascular ultrasound (IVUS). Lifestyle during period the-lifestyle modification score. significant decrease 12.9% observed...
Low density lipoproteins (LDLs) are heterogeneous aggregations of molecules different particle sizes, and small-size LDLs more potent risk factors for atherosclerosis. We examined the qualitative characteristics in patients with stable coronary artery disease (CAD) receiving statin therapy. LDL-particle size was estimated based on LDL-cholesterol/apolipoprotein B ratio (LDL-C/apoB) 214 age-adjusted men The LDL-C/apoB significantly lower CAD (+) group (n = 107) than (-) (median, 1.17 versus...
Thromboangiitis obliterans (TAO) can lead to the development of critical limb-threatening ischemia (CLTI). Despite conventional treatments, such as smoking cessation or revascularization, young patients (<50 years) still require limb amputation. Therapeutic angiogenesis using bone marrow-derived mononuclear cell (BM-MNC) implantation has been tested and shown have reasonable efficacy in CLTI. In this multicenter prospective clinical trial, we evaluated safety BM-MNC CLTI with TAO.
Combined therapy with a statin and calcium channel blocker, which can improve lipid metabolism reduce oxidative stress, may attenuate coronary vasoconstriction in patients spastic angina (CSA). After 6 months of benidipine pravastatin, an acetylcholine provocation test was performed second time 25 CSA. The were divided into 2 groups according to whether the result this positive (n = 13) or negative 12). designated as when intracoronary injection induced angiographically demonstrable total...
Progress in reperfusion therapy for acute myocardial infarction (AMI) has greatly reduced phase mortality, but few data exist regarding the time trends left ventricular (LV) remodeling hospital survivors of AMI.The study enrolled 813 patients with AMI who had received and survived to discharge. The were divided into chronological groups: first treatment between 1989 1992, n=196; 1993 1995, n=193; 1996 1998, n=211; 1999 2002, n=213. A comparison was made LV ejection fraction (LVEF)...
Patients with hypertrophic cardiomyopathy (HCM) in sinus rhythm commonly show the fourth heart sound (S4). The lack of S4 may be a marker impaired atrial function HCM patients rhythm.This retrospective study consisted 47 who had undergone phonocardiography and cardiopulmonary exercise test. primary outcome was composite cardiac death, stroke, hospitalization for worsening failure, newly developed fibrillation (AF). detected 38 43 (88%). Peak oxygen consumption highest (23.6 ± 5.6 mL/kg/min),...
Aim: Obesity is a well known strong risk factor for coronary artery disease (CAD). We prospectively investigated the influence of body mass index (BMI) on inhibitory effects pravastatin against development atherosclerosis.Methods: In 56 patients with stable CAD, 3-dimensional intravascular ultrasound was performed in matched segments at baseline and after 6-month treatment pravastatin.Results: The plaque volume significantly reduced by 11% (p<0.001 vs. baseline). percent positively...
Angiotensin-converting enzyme inhibitors (ACE-I) and angiotensin II receptor blockers (ARB) have been shown to a significant cardioprotective effect in high-risk patients after myocardial infarction (MI). However, there are few data on the effects of these drugs left-ventricular (LV) remodeling MI Japanese patients.We randomly assigned 100 with anterior-wall who had received reperfusion therapy treatment either enalapril (n=50) or losartan (n=50), calculated LV ejection fraction (LVEF)...
Cardiac rupture (CR) is a catastrophic complication of acute myocardial infarction. Primary percutaneous coronary intervention (pPCI) reduces the incidence CR. This study aimed to investigate clinical risk factors and characteristics CR after pPCI.This was retrospective, case-control, multicenter study. We enrolled 2444 consecutive patients with ST-elevation infarction (STEMI) who had undergone pPCI between 2009 2015; 33 experienced (1.35%): 19 were assigned as early (≤72 h) 14 late (>72 h)....
Abstract Aims The impact of hospital volume on clinical performance has been investigated by many researchers to date and thought that it is associated with quality care outcome for patients heart failure (HF). This study sought determine whether annual admissions HF per cardiologist are process care, mortality, readmission. Methods results Among the nationwide registry ‘Japanese all cardiac vascular diseases ‐ diagnostics procedure combination’ data collected from 2012 2019, a total 1 127...
Objective A direct renin inhibitor, aliskiren, has a longer stable antihypertensive effect compared with other renin-angiotensin-aldosterone system (RAAS) inhibitors. Methods This study was 6-month, single-center, open trial conducted between December 2010 and November 2011 to assess the of adding aliskiren (300 mg) treatment essential hypertension patients whose target blood pressure (BP) had not been achieved whether it possible reduce amount drugs used. Results The results showed an...
The coronavirus disease 2019 pandemic occurred in several countries, making the conventional medical system difficult to maintain. Recent recommendations aim prevent nosocomial infections and among health care workers. Therefore, establishing a cardiovascular under an emergency for patients with ST-segment elevation myocardial infarction (STEMI) is desired. This study aimed determine relationship between prognosis door-to-balloon time (DBT) shortening based on severity arrival.This...
Background Calcium channel blockers (CCBs) may have a positive influence on the long-term prognosis of Japanese patients with ischemic heart disease. Methods and Results The effect nifedipine-retard (NR) (n=202) compared that non-CCB treatment (n=92) secondary prevention myocardial infarction (MI) was retrospectively investigated in who had survived acute MI between 1987 1996. primary endpoint occurrence cardiac death or non-fatal MI. median follow-up 6.3±2.4 years. incidence events 8.9% NR...
Arterial and venous thrombi can coexist without preexisting conditions, such as malignant disease, thrombotic predisposition, or arteriovenous shunt. We herein report a case of acute cerebral infarction pulmonary thromboembolism in the absence underlying disease. A 71-year-old woman presented with left hemiplegia. On an examination, her oxygen saturation was 91% on ambient air despite chest symptoms clear lung fields radiograph. The patient finally diagnosed caused by large artery...