A5102989200- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Esophageal Cancer Research and Treatment
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- Helicobacter pylori-related gastroenterology studies
- Colorectal and Anal Carcinomas
- Genetic factors in colorectal cancer
- Esophageal and GI Pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Sarcoma Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Estrogen and related hormone effects
- Cancer-related Molecular Pathways
- Lung Cancer Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- Breast Cancer Treatment Studies
- Monoclonal and Polyclonal Antibodies Research
- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Telomeres, Telomerase, and Senescence
- Peroxisome Proliferator-Activated Receptors
- Cancer-related gene regulation
- Soft tissue tumor case studies
Teikyo University of Science
2024
Mita Hospital
2011-2012
Chemotherapy Foundation
2011
Ibaraki Prefectural Central Hospital
1998-2008
National Cancer Research Institute
1977-1993
Tokyo Women's Medical University Hospital
1993
Tokyo National Hospital
1991-1993
Women Medical College
1991
National Cancer Center
1986-1989
Uji Hospital
1989
Intestinal metaplasia of the human stomach was classified into two types, complete and incomplete. The type associated with intestinal marker enzymes sucrose alpha-D-glucohydrolase, alpha, alpha-trehalase, aminopeptidase (microsomal) (APM), alkaline phosphatase (ALP). Tissue this contained goblet cells Paneth's but not high-iron diamine (HID)-positive mucin staining HID-Alcian blue. incomplete APM, cells, HID-positive ALP, or cells. For examination distribution types in 84, 27, 16 resected...
In view of the many studies early stage colorectal carcinoma from Japan, it is essential to know whether criteria for histologic diagnosis are similar in Japan and Western countries.Eight expert pathologists (4), North America (2), Europe (2) individually reviewed microscope slides 20 lesions Japanese patients who had undergone endoscopic mucosal resection or surgery because and/or adenoma was suspected. The indicated pathologic findings on which they based each diagnosis.For 11 that showed...
Severe diarrhea occurred during daily intraperitoneal administration of 7‐ethyl‐10‐[4‐(l‐piperidino)‐l‐piperidino]carbonyloxycamptothecin (CPT‐11) at a dose 50 mg/kg in athymic mouse. Serial determination CPT‐11 and 7‐ethyl‐10‐hydroxycamptothecin (SN‐38), with the use an on‐line solid extraction HPLC system, demonstrated that much higher levels compounds are retained intestine blood plasma after five consecutive injections than single injection. Histologic examination gastrointestinal tract...
We report 92 patients treated with esophagectomy for superficial esophageal carcinoma (SEC; 9.1% of all resected cancers at our institution). the operative mortality rate was 5.4%. in 24 cases, cancer invasion limited to mucosa, and 68 submucosa. Twenty-three former group had no lymph node involvement, whereas (35.3%) latter metastases. 5-year survival after surgery SEC mucosa 83.5%, which significantly better than that invading submucosa (54.9%). No recurrent disease occurred lesions...
In recent years, several reports on the experimental and clinical applications of Gianturco stent (self-expanding stainless steel stent) have been published. However, to our knowledge, use stents in rectosigmoid strictures has not reported. We used self-expanding dilate caused by nonresectable recurrent neoplasm. Insertion dilation (sigmoid colon rectum) two patients were successful. Accordingly, these able maintain bowel activity avoid palliative loop colostomy. believe that this procedure...
The present report reviews results from 20 carcinosarcoma patients, and compares them with 773 cases of squamous cell carcinoma the esophagus treated surgically at National Cancer Center Hospital 1971 to 1988. Although there were no significant differences in age, sex, symptoms or location between two groups, group had morphological characteristics as follows. (1) Seventy-five percent carcinosarcomas elevated type. (2) tumor was large. (3) depth invasion limited esophageal wall 80%...
Abstract Seventy‐nine patients with thoracic esophageal carcinoma underwent transthoracic esophagectomy neck, mediastinal, and abdominal lymphadenectomy. The operative mortality rate was 3.8%. Fifty‐seven (72.2%) had metastasis in the lymph nodes. Though three classified as pTis no positive nodes, nine (50.0%) of a pT1 5‐year survival for 57 nodes 33.6%. Twenty‐nine (36.7%) neck; 47 (59.5%), mediastinum; 33 (41.8%), abdomen. Their rates were 30.0%, 24.4%, 38.4%, respectively. differences...
BACKGROUND Large discrepancies have been found between Western and Japanese pathologists in the diagnosis of adenoma/dysplasia versus carcinoma for gastric colorectal glandular lesions. It is important to determine whether similar differences exist esophageal squamous METHODS Eleven expert gastrointestinal from Japan, North America, Europe individually reviewed a set microscopic slides containing 21 sections biopsies corresponding endoscopic mucosal resection specimens patients with...
Two hundred thirty-two biopsies of benign breast conditions from the National Cancer Center Hospital in Tokyo and 263 comparable Memorial New York City were reviewed. The component lesions disease identified evaluated according to their relative frequency for different ages. Apocrine cysts, apocrine hyperplasia, intraductal sclerosing adenosis, blunt duct atypical lobular hyperplasia at least twice as common American women. Solitary papillomas among Japanese patients tended show more...
Abstract Of 393 patients with squamous‐cell carcinoma in the thoracic esophagus, 60 were found by histologic examination to have intramural metastasis. Metastases 50 of these identified gross inspection. There appeared be no preference for location proximal primary lesion. Eighteen had metastasis gastric wall, which suggested existence communicating lymphatic channels between wall esophagus and stomach. All tumors invaded beyond submucosa. These (group A) compared a group matched control...
Background : Various types of classification gastritis have been proposed, but no plausible has available until now. The Research Society for Gastritis performed a pilot study to establish an endoscopic classification, taking into consideration the following: (i) ease use; (ii) permitting everyone common image; and (iii) presence histopathological evidence. Methods One hundred fifty‐five patients were enrolled underwent gastroscopy. Eight basic histological (superficial, hemorrhagic,...
In 1999, a group of Western and Asian pathologists gathered in Vienna reached consensus regarding the classification gastrointestinal epithelial neoplasia. this study, that is applied to colorectal adenomas.Colorectal adenomas from 1552 patients were histologically classified according categories listed Vienna: category 3, low-grade dysplasia; 4.1, high-grade 4.2, carcinoma situ; 4.3, suspicious intramucosal carcinoma; 5.1, 5.2, submucosal carcinoma. The criteria used diagnose these lesions...
In order to clarify the histogenesis and direction of differentiation spindle-cell sarcomatous components esophageal carcinosarcoma, 20 cases disease were reviewed histologically immunohistochemically using avidin-biotin-peroxidase complex method with monoclonal polyclonal antibodies various keratins, vimentin, desmin, muscle specific act in S-100 protein. A gradual transition between carcinomatous spindle cell was present all cases. Positive immunoreactivity for keratins found areas Spindle...
Five patients with hepatocellular carcinoma in the caudate lobe were evaluated. Computed tomography (CT) scan and/or angiography clearly demonstrated multiple intrahepatic metastases four (80%), and tumor thrombi portal vein two (40%), inferior vena cava one. Even though there was no recognizable lung metastasis, found orbita one patient, ribs thoracic vertebrae patients. Four died after a mean period of 5.5 months from initial diagnosis. The mechanism for early invasion into vessels arising...
A review of 2369 cases resected primary colorectal carcinoma identified 15 diffusely infiltrating carcinoma. Depending on the histologic pattern and extent, these were classified as linitis plastica (LP) type (seven cases) or lymphangiosis (LA) (eight cases). The LP consisted poorly differentiated adenocarcinoma signet ring cell carcinoma; it showed an annularly thickened rigid bowel wall. LA moderately adenocarcinoma. colon wall was hemilaterally at mesenteric side. prognosis extremely poor...
Helix Pomatia (HPA) and carcinoembryonic antigen (CEA) staining were studied in 113 primary breast carcinomas, 63 metastatic lymph nodes 10 resected local recurrences, using the avidin-biotin-peroxidase complex (ABC) method. Positive percentage rates 41 (46/113) for HPA 24 (27/113) CEA tumors, 80 (8/10) but only (1/10) lesions. showed a statistically significant correlation with negative estrogen receptor (ER) status (r -0.25, P = 0.05) high nuclear grade 0.20, 0.04). Cancers positive...
A rare association between primary pulmonary marginal zone B‐cell lymphoma of mucosa‐associated lymphoid tissue (MALT lymphoma), and immunoglobulin light chain (AL) amyloidosis is described in a 65‐year‐old woman suffering from rheumatoid arthritis (RA). All four nodules the resected upper lobe lung had similar histological appearance. They were composed small–medium‐sized atypical lymphocytes. Centrocyte‐like cells lymphoepithelial lesions. Immunohistochemically, tumor clonally expressed...
Telomerase activity is thought to be necessary for cellular immortality and carcinogenesis. The mRNA that encodes the telomerase catalytic subunit (hTERT) has recently been identified, expression of hTERT regulate activation telomerase. To determine at what stage carcinogenesis cells begin express hTERT, we analysed in gastric carcinoma precancerous conditions, focusing on chronic gastritis with or without intestinal metaplasia.Using reverse transcription-polymerase chain reaction, gene was...