A5088387334- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Diabetes Management and Research
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pharmacology and Obesity Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Diabetes Management and Education
- Diet and metabolism studies
- Regulation of Appetite and Obesity
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Lipoproteins and Cardiovascular Health
- Cardiovascular Function and Risk Factors
- Growth Hormone and Insulin-like Growth Factors
- Chronic Kidney Disease and Diabetes
- Pancreatitis Pathology and Treatment
- Endoplasmic Reticulum Stress and Disease
- Obstructive Sleep Apnea Research
- Gastric Cancer Management and Outcomes
- Neuroendocrine Tumor Research Advances
Yokohama City University
2016-2025
Japan Association for Diabetes Education and Care
2011-2024
Yokohama City University Hospital
2013-2023
Yokohama City University Medical Center
2008-2021
Kyoto University
2021
Yamato University
2020
Nagoya City University
2020
Fujisawa City Hospital
2018-2019
Chigasaki Rehabilitation College
2018
Advanced Materials Enterprises (China)
2018
The adipocyte-derived hormone adiponectin has been proposed to play important roles in the regulation of energy homeostasis and insulin sensitivity, it reported exhibit putative antiatherogenic properties <i>in vitro</i>. In this study we generated adiponectin-deficient mice directly investigate whether a physiological protective role against diabetes atherosclerosis vivo</i>. Heterozygous (<i>adipo</i> <sup>+/−</sup>) showed mild resistance, while homozygous <sup>−/−</sup>) moderate...
The adipocyte-derived hormone adiponectin has been shown to play important roles in the regulation of energy homeostasis and insulin sensitivity. In this study, we analyzed globular domain (gAd) transgenic (Tg) mice crossed with leptin-deficient ob/ob or apoE-deficient mice. Interestingly, despite an unexpected similar body weight, gAd Tg showed amelioration resistance β-cell degranulation as well diabetes, indicating that leptin appeared have both distinct overlapping functions....
Based on the fact that aging is associated with a reciprocal decrease of osteogenesis and an increase adipogenesis in bone marrow osteoblasts adipocytes share common progenitor, this study investigated role PPARγ, key regulator adipocyte differentiation, metabolism. Homozygous PPARγ-deficient ES cells failed to differentiate into adipocytes, but spontaneously differentiated osteoblasts, these were restored by reintroduction PPARγ gene. Heterozygous mice exhibited high mass increased...
Based on the fact that aging is associated with a reciprocal decrease of osteogenesis and an increase adipogenesis in bone marrow osteoblasts adipocytes share common progenitor, this study investigated role PPARγ γ, key regulator adipocyte differentiation, metabolism.Homozygous γ-deficient ES cells failed to differentiate into adipocytes, but spontaneously differentiated osteoblasts, these were restored by reintroduction γ gene.Heterozygous mice exhibited high mass increased...
Peroxisome proliferator-activated receptor (PPAR) γ is a ligand-activated transcription factor and member of the nuclear hormone superfamily that thought to be master regulator fat storage; however, relationship between PPARγ insulin sensitivity highly controversial. We show here supraphysiological activation by agonist thiazolidinediones (TZD) markedly increases triglyceride (TG) content white adipose tissue (WAT), thereby decreasing TG liver muscle, leading amelioration resistance at...
Adiponectin/Acrp30 is a hormone secreted by adipocytes, which acts as an antidiabetic and antiatherogenic adipokine. We reported previously that AdipoR1 -R2 serve receptors for adiponectin mediate increased fatty acid oxidation glucose uptake adiponectin. In the present study, we examined expression levels roles of AdipoR1/R2 in several physiological pathophysiological states such fasting/refeeding, obesity, insulin resistance. Here show target organs, skeletal muscle liver, significantly...
To investigate the role of insulin receptor substrate (IRS)-2 in vivo, we generated IRS-2-deficient mice by gene targeting. Although homozygous (IRS-2-/- mice) had a body weight similar to wild-type mice, they progressively developed type 2 diabetes at 10 weeks. IRS-2-/- showed resistance and defect insulin-stimulated signaling pathway liver but not skeletal muscle. Despite resistance, amount beta-cells was reduced 83% that which marked contrast 85% increase IRS-1-deficient (IRS-1-/-...
Glucose metabolism in glycolysis and mitochondria is pivotal to glucose-induced insulin secretion from pancreatic β cells. One or more factors derived other than pyruvate appear be required for the generation of mitochondrial signals that lead secretion. The electrons glycolysis-derived reduced form nicotinamide adenine dinucleotide (NADH) are transferred through NADH shuttle system. By abolishing function, increases autofluorescence, membrane potential, adenosine triphosphate content were...
Mice with a targeted gene disruption of p85α, regulatory subunit phosphoinositide 3-kinase, had impaired B cell development at the pro–B stage, reduced numbers mature cells and peritoneal CD5 + Ly-1 cells, proliferative responses, no T cell–independent antibody production. These phenotypes are nearly identical to those Btk −/− or xid (X-linked immunodeficiency) mice. results provide evidence that p85α is functionally linked pathway in antigen receptor–mediated signal transduction pivotal functions.
OBJECTIVE This trial compared the efficacy and safety of first oral glucagon-like peptide 1 (GLP-1) receptor agonist, semaglutide, as monotherapy with placebo in patients type 2 diabetes managed by diet exercise alone. Two estimands addressed two efficacy-related questions: a treatment policy estimand (regardless product discontinuation or rescue medication use) (on without all randomized patients. RESEARCH DESIGN AND METHODS was 26-week, phase 3a, randomized, double-blind,...
Glucokinase (Gck) functions as a glucose sensor for insulin secretion, and in mice fed standard chow, haploinsufficiency of β cell–specific Gck (Gck+/–) causes impaired secretion to glucose, although the animals have normal cell mass. When high-fat (HF) diet, wild-type showed marked hyperplasia, whereas Gck+/– demonstrated decreased replication insufficient hyperplasia despite showing similar degree resistance. DNA chip analysis revealed receptor substrate 2 (Irs2) expression HF diet–fed...
Thiazolidinediones have been shown to up-regulate adiponectin expression in white adipose tissue and plasma levels, these up-regulations proposed be a major mechanism of the thiazolidinedione-induced amelioration insulin resistance linked obesity. To test this hypothesis, we generated knock-out (adipo-/-) ob/ob mice with C57B/6 background. After 14 days 10 mg/kg pioglitazone, diabetes were significantly improved association significant up-regulation serum levels. Amelioration was attributed...
Diet composition alters the metabolic states of adipocytes and hepatocytes in diabetes. The effects dipeptidyl peptidase-4 (DPP-4) inhibition on adipose tissue inflammation fatty liver have been obscure. We investigated extrapancreatic DPP-4 visceral fat liver.We diet-induced changes β-cell-specific glucokinase haploinsufficient (Gck(+/-)) diabetic mice. challenged animals with a diet containing combination sucrose oleic acid (SO) or linoleic (SL). Next, we assessed inhibitor,...
In recent years, several oral antidiabetic drugs with new mechanisms of action have become available, expanding the number treatment options. Sodium/glucose cotransporter-2 (SGLT2) inhibitors are a class an insulin-independent mechanism promoting urinary glucose excretion. We report results combined Phase 2 and 3 clinical study (Japic CTI-101349) SGLT2 inhibitor tofogliflozin (CSG452, RG7201) in Japanese patients type diabetes mellitus. The efficacy safety were assessed this multicenter,...
PPARγ is a ligand-activated transcription factor and functions as heterodimer with retinoid X receptor (RXR). Supraphysiological activation of by thiazolidinediones can reduce insulin resistance hyperglycemia in type 2 diabetes, but these drugs also cause weight gain. Quite unexpectedly, moderate reduction activity observed heterozygous PPARγ-deficient mice or the Pro12Ala polymorphism human PPARγ, has been shown to prevent obesity induced high-fat diet. In this study, we investigated...