A5009086600- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- Vitamin D Research Studies
- Cytokine Signaling Pathways and Interactions
- Systemic Sclerosis and Related Diseases
- Myasthenia Gravis and Thymoma
- Rheumatoid Arthritis Research and Therapies
- Polyomavirus and related diseases
- Sphingolipid Metabolism and Signaling
- Powdery Mildew Fungal Diseases
- Monoclonal and Polyclonal Antibodies Research
- Psoriasis: Treatment and Pathogenesis
- Mycobacterium research and diagnosis
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Immune Cell Function and Interaction
- RNA regulation and disease
- Hereditary Neurological Disorders
- RNA Interference and Gene Delivery
- Amyotrophic Lateral Sclerosis Research
- Autoimmune and Inflammatory Disorders Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Medical and Biological Ozone Research
National Hospital Organization Hokkaido Medical Center
2016-2025
Yonezawa Chuo Senior High School
2016-2017
Hokuto Hospital
2017
Niigata University
2017
Obihiro Kosei General Hospital
2017
Hokuyukai Neurology Hospital
2003-2016
Nagasaki Kawatana Medical Center
2016
Tohoku University
2016
Kushiro Rosai Hospital
2015
Neurology, Inc
2011
Abstract Although recent animal studies have fuelled growing interest in Ab-independent functions of B cells, relatively little is known about how human cells and their subsets may contribute to the regulation immune responses either health or disease. In this study, we first confirm that effector cytokine production by normal context dependent demonstrate involves reciprocal proinflammatory anti-inflammatory cytokines. We further report network dysregulated patients with autoimmune disease...
Background: Treatment with natalizumab, a monoclonal antibody against the adhesion molecule very late activation antigen 4, an ␣4 1 integrin, was recently associated development of progressive multifocal leukoencephalopathy, demyelinating disorder central nervous system caused by JC virus infection.Objective: To test effect natalizumab treatment on CD4 ϩ /CD8 T-cell ratios in cerebrospinal fluid (CSF) and peripheral blood.Design: Prospective longitudinal study.Setting: Academic private...
Abstract Objective Our objective was to study in vivo biological effects of natalizumab on immune cell phenotype and function multiple sclerosis (MS) patients. Methods Blood obtained before after serial monthly infusions track functional expression VLA‐4 migratory capacity cells. The impact infusion activation thresholds cells evaluated. Results Preinfusion differed across subsets. Natalizumab significantly, albeit partially, diminished circulating Cell subsets were differentially affected....
To assess safety and immune modulation by BHT-3009, a tolerizing DNA vaccine encoding full-length human myelin basic protein, in patients with multiple sclerosis (MS).The study was randomized, double-blind, placebo-controlled trial. Subjects receiving placebo were crossed over into an active arm after treatment unblinding.The trial conducted at 4 academic institutions within North America. Patients Thirty relapsing-remitting or secondary progressive MS who not taking any other...
<h3>Objective:</h3> To clarify the prevalence and clinical characteristics of neuromyelitis optica spectrum disorders (NMOSD) in Japan compare them with those other ethnic populations. <h3>Methods:</h3> Data processing sheets were sent to all related institutions northern collected from April May 2016. Prevalence was determined on March 31, 2016, using 2015 International Panel for NMO Diagnosis criteria. <h3>Results:</h3> The crude 4.1/100,000 (95% confidence interval 2.2–6.9) NMOSD Japan, a...
Cognitive impairment could affect quality of life for patients with multiple sclerosis (MS), and cognitive function may be correlated several factors such as depression fatigue. This study aimed to evaluate in Japanese MS the association between apathy, fatigue, depression. The Brief Repeatable Battery Neuropsychological tests (BRB-N) was performed 184 163 healthy controls matched age, gender, education. Apathy Scale (AS), Fatigue Questionnaire (FQ), Beck Depression Inventory Second Edition...
Type 1 diabetes mellitus is recognized as a T-cell-mediated autoimmune disease. Vitamin D compounds are known to suppress T-cell activation by binding the vitamin receptor (VDR); and thus, VDR gene polymorphisms may be related diseases. We, therefore, investigated polymorphism in type diabetes. We examined Bsm I 203 diabetic patients 222 controls, association between their onset pattern. found significantly higher frequency of B allele diabetics overall, compared with controls (P = 0.0010)....
We previously reported that prevalence of multiple sclerosis (MS) in Japan was 8.6/100,000 individuals 2001. This much higher than from Asian countries. A second epidemiologic survey conducted to assess changes MS and incidence over the last 30 years Tokachi province Hokkaido, northernmost island Japan.The authors studied frequency community Province, where population has stabilized between 350,000 360,000 years. The at same institutions using methods as first 2001.On March 31, 2006, 47...
No large-scale studies have compared the efficacy of intravenous methylprednisolone pulse therapy (IVMP) for multiple sclerosis (MS) and neuromyelitis optica (NMO).To explain differences in treatment responses MS NMO patients to IVMP.Changes neurological symptoms/signs Expanded Disability Status Scale (EDSS) scores before within 1 week IVMP completion were obtained 2010 at 28 institutions, retrospectively collated from 271 (478 courses) 73 (118 cases.In patients, decreased EDSS score was...
Background and purpose The prevalence of multiple sclerosis ( MS ) is considered to be lower in East Asia than Western countries. An increasing trend has been reported globally for the . We investigated changes clinical characteristics Tokachi province Hokkaido, northern Japan from 2001 2016. Methods Prevalence was determined on 31 March Data‐processing sheets were collected all ‐related institutions province. applied Poser's diagnostic criteria as used our previous three studies. Cases...
<b><i>Background:</i></b> Oligoclonal IgG bands (OCB) are present in most patients with MS Western countries; however, Japanese patients, the OCB-positive rate is not as high. A relationship between immunogenetic backgrounds, namely, human leukocyte antigen (HLA) DR2 and DR4 positivity, OCB production from Hokkaido, northernmost island of Japan, has been previously suggested by authors. <b><i>Objectives:</i></b> To investigate role to verify interaction backgrounds positivity....
Higher latitude and human leukocyte antigen (HLA)-DRB1*04:05 increase susceptibility to multiple sclerosis (MS) in the Japanese population, but their effects on disease severity are unknown. We aimed clarify of HLA-DRB1 HLA-DPB1 genes patients with MS. enrolled 247 MS 159 healthy controls (HCs) from northernmost main island Japan, Hokkaido Island (42–45° north), 187 235 HCs southern half (33–35° north) archipelago (33–45° north). genotyped alleles, compared demographic features, analyzed...
HLA genotype-clinical phenotype correlations are not established for multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD). We studied HLA-DRB1/DPB1 genotype-phenotype in 528 MS 165 NMOSD cases using Japan MS/NMOSD Biobank materials. HLA-DRB1*04:05, DRB1*15:01 DPB1*03:01 correlated with susceptibility DRB1*01:01, DRB1*09:01, DRB1*13:02 DPB1*04:01 were protective against MS. HLA-DRB1*15:01 was associated increased optic neuritis cerebellar involvement worsened visual...