A5022594173- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Advanced Neuroimaging Techniques and Applications
- Mycobacterium research and diagnosis
- Monoclonal and Polyclonal Antibodies Research
- Advanced MRI Techniques and Applications
- Systemic Lupus Erythematosus Research
- Fluorine in Organic Chemistry
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Autoimmune Neurological Disorders and Treatments
- Polyomavirus and related diseases
- Neuroscience and Neuropharmacology Research
- Immunotherapy and Immune Responses
- Immunodeficiency and Autoimmune Disorders
- Myasthenia Gravis and Thymoma
- Tuberculosis Research and Epidemiology
- Pharmacological Effects of Natural Compounds
- Ultrasound Imaging and Elastography
- Synthesis and Reactions of Organic Compounds
- Cancer therapeutics and mechanisms
- RNA regulation and disease
- Systemic Sclerosis and Related Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Hereditary Neurological Disorders
Juntendo University Hospital
2011-2025
Juntendo University
2015-2024
National Epilepsy Center
2023
Astellas Pharma (Japan)
2022
Hyogo Social Welfare Corporation
1989-2021
Takeda (Japan)
2019-2020
Pharmac
2020
Kissei Pharmaceutical (Japan)
2019
The University of Tokyo
2003-2016
Hokkaido University
2011-2014
Behavioral and psychological symptoms of dementia (BPSDs) negatively impact the prognosis patients increase caregiver distress. The aims this study were to clarify differences trajectories 12 kinds BPSDs by disease severity in four major dementias develop charts showing frequency, severity, associated distress (ACD) using data a Japan multicenter (J-BIRD).We gathered Neuropsychiatric Inventory (NPI) with Alzheimer's (AD; n = 1091), Lewy bodies (DLB; 249), vascular (VaD; 156), frontotemporal...
<h3>BACKGROUND AND PURPOSE:</h3> Synthetic MR imaging enables the creation of various contrast-weighted images including double inversion recovery and phase-sensitive from a single quantification scan. Here, we assessed whether synthetic is suitable for detecting MS plaques. <h3>MATERIALS METHODS:</h3> Quantitative conventional data on 12 patients with were retrospectively analyzed. T2-weighted, FLAIR, recovery, produced after T1 T2 values proton density. Double optimized each patient by...
<h3>BACKGROUND AND PURPOSE:</h3> Synthetic FLAIR images are of lower quality than conventional images. Here, we aimed to improve the synthetic image using deep learning with pixel-by-pixel translation through conditional generative adversarial network training. <h3>MATERIALS METHODS:</h3> Forty patients MS were prospectively included and scanned (3T) acquire MR imaging created SyMRI software. Acquired data divided into 30 training 10 test datasets. A was trained generate improved from raw as...
Neuromyelitis optica (NMO) is an inflammatory disease characterized by recurrent attacks of optic neuritis and myelitis. It generally accepted that autoantibodies against aquaporin 4 water channel protein play a pathogenic role in neuromyelitis optica. We have recently reported plasmablasts are increased the peripheral blood this autoimmune disease, capable producing 4. Here, we demonstrate CD138+HLA-DR+ plasmablasts, subset IgG-producing cells, enriched among cerebrospinal fluid (CSF)...
Cognitive impairment could affect quality of life for patients with multiple sclerosis (MS), and cognitive function may be correlated several factors such as depression fatigue. This study aimed to evaluate in Japanese MS the association between apathy, fatigue, depression. The Brief Repeatable Battery Neuropsychological tests (BRB-N) was performed 184 163 healthy controls matched age, gender, education. Apathy Scale (AS), Fatigue Questionnaire (FQ), Beck Depression Inventory Second Edition...
Few reports describe the influence pregnancy has on annualized relapse rate (ARR) in neuromyelitis optica spectrum disorder (NMOSD).To examine pregnancy-related attacks (attacks during or within 1 year postpartum) and identify risk factors for an attack Japanese NMOSD patients.We retrospectively reviewed 139 women whom had aquaporin-4 (AQP4) antibody-positive NMOSD. Among 114 patients with information, 47 56 pregnancies. We compared ARR before, after pregnancy.Of pregnancy, 22 (46.8%) a of...
A number of MR-derived quantitative metrics have been suggested to assess the pathophysiology MS, but reports about combined analyses these are scarce. Our aim was spatial distribution parameters for white matter myelin and axon integrity in patients with relapsing-remitting MS by multiparametric MR imaging. Twenty-four 24 age- sex-matched controls were prospectively scanned synthetic 2-shell diffusion Synthetic imaging data used retrieve relaxometry (R1 R2 relaxation rates proton density)...
IntroductionDespite differences in the pathogenesis and treatment of multiple sclerosis (MS) neuromyelitis optica spectrum disorders (NMOSD), it remains difficult to distinguish them. In this study, we aimed discriminate between MS NMOSD using diffusion tensor imaging (DTI), free water (FW) imaging, neurite orientation dispersion density (NODDI).MethodsThirty patients with relapsing-remitting (RR) MS, 18 positive anti-aquaporin-4 immunoglobulin G seroreactivity, 20 age- sex- matched...
✓ Dissecting intracranial arterial aneurysms were identified in a 16-year-old girl and 48-year-old man with moyamoya disease. Hemiplegia or tetraplegia rapidly developed. Angiography revealed bilateral stenoses occlusion of the bifurcation internal carotid arteries (ICA's) an unusual vascular network at base brain. Autopsy confirmed massive hemorrhage from thalamus putamen, intraventricular extension. The segments both ICA's markedly stenotic patients, due to eccentric fibroelastic intimal...
The aim of this study was to evaluate the gender and age differences in normal adult human brain, using voxel-based morphometry.In study, 227 right-handed adults (male:female ¼ 111:116) were examined.Three-dimensional magnetic resonance brain images each subject segmented into gray white matter statistical parametric mappings.All individual data transformed standard space then divided older younger groups before examining effects gender.There a significant negative correlation between...
<h3>BACKGROUND AND PURPOSE:</h3> T1 and T2 values proton density can now be quantified on the basis of a single MR acquisition. The myelin edema in voxel also estimated from these values. purpose this study was to evaluate multiparametric quantitative imaging model that assesses for characterizing plaques, periplaque white matter, normal-appearing matter patients with MS. <h3>MATERIALS METHODS:</h3> We examined 3T data 21 partial volume, excess parenchymal water inverse transverse relaxation...
Abstract Intracellular trafficking of receptor proteins is essential for neurons to detect various extracellular factors during the formation and refinement neural circuits. However, precise mechanisms underlying neurotrophin receptors synapses remain elusive. Here, we demonstrate that a brain-enriched sorting nexin, ARHGAP33, new type regulator intracellular TrkB, high-affinity brain-derived neurotrophic factor. ARHGAP33 knockout (KO) mice exhibit reduced expression synaptic impaired spine...
<h3>BACKGROUND AND PURPOSE:</h3> Myelin and axon volume fractions can now be estimated via MR imaging in vivo, as the g-ratio, which equals ratio of inner to outer diameter a nerve fiber. The purpose this study was evaluate WM damage patients with MS novel technique. <h3>MATERIALS METHODS:</h3> Twenty relapsing-remitting combined total 149 chronic plaques were analyzed. fraction calculated based on simultaneous tissue relaxometry. Intracellular CSF compartment quantified neurite orientation...
Eculizumab is a humanized monoclonal antibody that targets complement protein C5 and inhibits terminal complement-mediated damage at the neuromuscular junction. Recently, REGAIN study showed eculizumab was effective well tolerated in patients with anti-acetylcholine receptor antibody-positive refractory generalized myasthenia gravis (gMG). However, there no consensus regarding which kind of gMG are selected to preferentially receive eculizumab.Between January December 2018, we followed 1388...
Pembrolizumab is an immune-checkpoints inhibitor that enhances the immune response against cancer cells and therefore useful for treatment of several carcinomas. However, pembrolizumab sometimes perturbs system resulting in various autoimmune neurological complications. In this situation, myositis due to a rare but not-negligible complication. Here, we report two cases pembrolizumab, with systemic involving levator palpebrae superioris, extraocular hindneck muscles.Case 1 was 78-year-old man...
Abstract Purpose To evaluate a vendor‐agnostic multiparametric mapping scheme based on 3D quantification using an interleaved Look–Locker acquisition sequence with T2 preparation pulse (3D‐QALAS) for whole‐brain T1, T2, and proton density (PD) mapping. Methods This prospective, multi‐institutional study was conducted between September 2021 February 2022 five different 3T systems from four prominent MRI vendors. The accuracy of this technique evaluated standardized system phantom....
N-methyl-d-aspartate (NMDA) receptors regulate structural plasticity by modulating actin organization within dendritic spines. Herein, we report identification and characterization of p250GAP, a novel GTPase-activating protein for Rho family proteins that interacts with the GluRepsilon2 (NR2B) subunit NMDA in vivo. The p250GAP mRNA was enriched brain, high expression cortex, corpus striatum, hippocampus, thalamus. Within neurons, highly concentrated postsynaptic density colocalized...
Abstract Programmed death-1 (PD-1) is a known immunoinhibitory receptor that contributes to immune evasion of various tumor cells and pathogens causing chronic infection, such as bovine leukemia virus (BLV) infection. First, in this study, establish method for the expression functional analysis PD-1, hybridomas producing monoclonal antibodies (mAb) specific PD-1 were established. Treatment with these anti-PD-1 mAb enhanced interferon-gamma (IFN-γ) production peripheral blood mononuclear...