A5103109255- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Pain Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Cerebrospinal fluid and hydrocephalus
- Functional Brain Connectivity Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuropeptides and Animal Physiology
- Neurosurgical Procedures and Complications
- Vestibular and auditory disorders
- Neurotransmitter Receptor Influence on Behavior
- EEG and Brain-Computer Interfaces
- Liver Disease and Transplantation
- Insect and Pesticide Research
- Neural dynamics and brain function
- Diet and metabolism studies
- Mycotoxins in Agriculture and Food
- Organ Transplantation Techniques and Outcomes
- Olfactory and Sensory Function Studies
- Veterinary Pharmacology and Anesthesia
- Hepatitis C virus research
- Health and Wellbeing Research
- Cerebrovascular and Carotid Artery Diseases
- Neurological and metabolic disorders
- Advanced MRI Techniques and Applications
Kyorin University
2019-2024
Chibune General Hospital
2023-2024
Osaka University
2015-2022
Henry Ford Hospital
2021-2022
Toranomon Hospital
2014-2021
University of Fukui Hospital
2021
Nagoya University Hospital
2020
University of Shizuoka
2004-2019
Komatsu (Japan)
2019
Toho University
2017
Behavioral and psychological symptoms of dementia (BPSDs) negatively impact the prognosis patients increase caregiver distress. The aims this study were to clarify differences trajectories 12 kinds BPSDs by disease severity in four major dementias develop charts showing frequency, severity, associated distress (ACD) using data a Japan multicenter (J-BIRD).We gathered Neuropsychiatric Inventory (NPI) with Alzheimer's (AD; n = 1091), Lewy bodies (DLB; 249), vascular (VaD; 156), frontotemporal...
Hot water extracts of coffee grinds and commercial instant solutions have been shown to exhibit marked antiviral virucidal activities against herpes simplex virus type 1 (HSV-1). Specifically, it has that caffeine N-methyl-pyridinium formate inhibit the multiplication HSV-1 in HEp-2 cells. The present study examined virological properties activity caffeic acid HSV-1. Caffeic inhibited vitro, while chlorogenic acid, a ester with quinic did not. These reagents not direct effect. one-step...
More than half of all human cancers are associated with mutations the TP53 gene. In regard to functional interaction remaining wild-type (WT) p53 allele, classified into two types, recessive and dominant-negative (DN) mutations. The latter mutant protein has a DN activity over WT allele. We previously showed that was useful as predictor poor outcome or risk factor for metastatic recurrence in patients some types cancers, regardless presence absence loss heterozygosity (LOH) p53, suggesting...
Background Sleep disturbances in Alzheimer disease (AD) may affect behavioral and psychological symptoms of dementia (BPSD). Our aim was to elucidate the associations between sleep other BPSD at different stages AD. Methods This investigation part a multicenter‐retrospective study Japan (J‐BIRD). Eligible for final analyses were 684 AD patients. Global severity estimated using Clinical Dementia Rating (CDR) scale. assessed Neuropsychiatric Inventory (NPI). We analyzed relationships according...
The CDKN2A and CDKN2B genes, encoding p16 p15 respectively, are located on chromosome 9p21, a locus at which frequent homozygous heterozygous deletions occur in many primary human tumors, including esophageal carcinoma. inhibit cyclin dependent kinase 4 (CDK4) CDK6 control cellular proliferation by preventing entry into the S phase of cell cycle. Their inactivation may contribute to uncontrolled growth cancer. We previously described exon 2 mutations pilot study 43 cancers. In order...
Magnetic resonance imaging of 28 patients with radiological and/or histopathologically proved ossification the ligamentum flavum (OLF) was reviewed. The locations OLF were cervical (n = 4), thoracic 22), and lumbar 2). On T1− T2-weighted images, demonstrated low signal intensity. Areas high or intermediate intensity within on T1-weighted images observed in three cases interpreted to be due fat infiltration. In six cases, areas spinal cord caused by compressing images....
Dementia with Lewy bodies (DLB) is characterized by progressive cognitive decline, fluctuating cognition, visual hallucinations, rapid eye movement sleep behavior disorder, and parkinsonism. DLB the second most common type of degenerative dementia all cases. However, DLB, particularly in early stage, underdiagnosed sometimes misdiagnosed other types dementia. Thus, it great interest investigating neurophysiological markers DLB.We introduced exact low-resolution brain electromagnetic...
The broader autism phenotype (BAP), which refers to the expression of behavioral and cognitive propensities that are milder but qualitatively similar those defining spectrum disorder, can play a crucial role in postpartum depression (PPD). We investigated whether pregnant women's BAP would increase risk for PPD, using representative birth cohort Japan. Pregnant women were enrolled Hamamatsu Birth Cohort (HBC) Study during their mid-gestation (N = 841) followed up until 3 months after...
Background: Although apathy is associated with damage to the frontal and temporal lobes in Alzheimer's disease (AD), crucial regions for patients amnestic mild cognitive impairment (aMCI) are unknown. Objective: To identify brain aMCI patients. M ethods: The subjects of this study were 98 who entered our dementia registry between March 1, 2009 April 30, 2015 satisfied criteria aMCI. association score Neuropsychiatric Inventory regional gray matter volume was analyzed using voxel-based...
We report a 34-year-old male who manifested T1 shortening of the cerebral cortices after more than 86 contrast-enhanced MRI studies. observed high-signal intensity (SI) on T1-weighted images (T1WIs) not only in globus pallidus, dentate nucleus, and pulvinar thalamus, but also pre- post-central gyri around calcarine sulcus. High SI was clearly demonstrated T1WI scans performed 11 years earlier. The high we these areas brain corresponded to with normal iron-deposition predilection. Gadolinium...
The Organ Procurement and Transplantation Network (OPTN)/United for Sharing (UNOS) policy regarding kidney allocation liver transplantation (LT) patients was implemented in August 2017. This study evaluated the effects of simultaneous liver-kidney (SLKT) on outcomes LT alone (LTA) with dysfunction. We analyzed adult primary LTA dysfunction at listing (estimated glomerular filtration rate [eGFR] less than 30 mL/minute or dialysis requirement) between January 2015 March 2019 using OPTN/UNOS...
Recently, cerebrospinal fluid (CSF) biomarkers related to Alzheimer’s disease (AD) have garnered a lot of clinical attention. To explore neurophysiological traits AD and parameters for its diagnosis, we examined the association between CSF electroencephalography (EEG) in 14 probable patients. Using exact low-resolution electromagnetic tomography (eLORETA), artifact-free 40-sesond EEG data were estimated with current source density (CSD) lagged phase synchronization (LPS) as parameters....
Idiopathic normal pressure hydrocephalus (iNPH) is a neuropsychiatric disease characterized by gait disturbance, cognitive dysfunction, and urinary incontinence that affects large population of elderly people. These symptoms, especially can potentially be improved cerebrospinal fluid (CSF) drainage, which more effective if performed at an early stage the disease. However, neurophysiological mechanisms these symptoms their recovery CSF drainage are poorly understood. In this study, using...
Background Specific ventriculomegaly features, including tight high‐convexity and medial subarachnoid spaces, are found on magnetic resonance images in patients with idiopathic normal pressure hydrocephalus (iNPH). However, some healthy elderly individuals no typical triad symptoms of iNPH also exhibit specific image features iNPH. Therefore, this study quantitatively clarified the brain morphology suspected objective (iNPH‐NOS). Methods We recruited divided them into two groups based their...
There is already an indication of a potential worldwide spread influenza projected for this coming autumn and winter. In review, we propose aqueous arginine solution as novel agent preventive measures possible chemotherapy against A virus infection. Influenza spreads among the human population through both droplets direct contact, hand mouth wash are primary measures. Upon infects epithelial cells upper respiratory tracts in initial phase infection over mucosal surface tracts, leading to...
Background: Previous research has demonstrated that the season of birth may predict development emotional and behavioral regulation during childhood or adolescence. This study examined whether predicts effortful control (i.e., ability to voluntarily choose course actions conflict plan for future) aggression use physical force expression anger toward others) in 18-month-old infants. Methods: Participants included 885 infants who were enrolled Hamamatsu Birth Cohort Mothers Children Hamamatsu,...