A5061232049- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- T-cell and B-cell Immunology
- Gastrointestinal disorders and treatments
- Genetic Neurodegenerative Diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Hereditary Neurological Disorders
- Mitochondrial Function and Pathology
- Blood disorders and treatments
- Systemic Lupus Erythematosus Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Cell Function and Interaction
- Advanced Neuroimaging Techniques and Applications
- RNA regulation and disease
- Nutrition and Health in Aging
- Gastrointestinal Tumor Research and Treatment
- Esophageal and GI Pathology
- Lymphoma Diagnosis and Treatment
- Blood properties and coagulation
- Antibiotics Pharmacokinetics and Efficacy
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Sphingolipid Metabolism and Signaling
- DNA Repair Mechanisms
- RNA Research and Splicing
- Amyotrophic Lateral Sclerosis Research
University of Fukui
2024-2025
Kanazawa University
2024-2025
National Center of Neurology and Psychiatry
2015-2024
Neurology, Inc
2024
Tokyo Medical and Dental University
2024
Kindai University
2014-2023
National Center for Global Health and Medicine
2023
Kyoto Prefectural University of Medicine
2023
Kansai Medical University
2023
Kyoto University
2023
Neuromyelitis optica (NMO) is an inflammatory disease affecting the optic nerve and spinal cord, in which autoantibodies against aquaporin 4 (AQP4) water channel protein probably play a pathogenic role. Here we show that B-cell subpopulation, exhibiting CD19 int CD27 high CD38 CD180 − phenotype, selectively increased peripheral blood of NMO patients anti-AQP4 antibodies (AQP4-Abs) are mainly produced by these cells patients. These B showed morphological as well phenotypical characteristics...
A mammalian nucleotide excision repair (NER) factor, the XPC–HR23B complex, can specifically bind to certain DNA lesions and initiate cell-free reaction. Here we describe a detailed analysis of its binding specificity using various substrates, each containing single defined lesion. highly sensitive gel mobility shift assay revealed that binds small bubble structure with or without damaged bases, whereas dual incision takes place only when damage is present in bubble. This evidence...
To evaluate the safety and efficacy of a humanized anti-interleukin-6 receptor antibody, tocilizumab (TCZ), in patients with neuromyelitis optica (NMO).Seven anti-aquaporin-4 antibody (AQP4-Ab)-positive NMO or spectrum disorders were recruited on basis their limited responsiveness to current treatment. They given monthly injection TCZ (8 mg/kg) therapy for year. We evaluated annualized relapse rate, Expanded Disability Status Scale score, numerical rating scales neurogenic pain fatigue....
Multiple sclerosis (MS), a putative autoimmune disease of the central nervous system (CNS), commonly presents as relapsing-remitting MS (RRMS), characterized by recurrent episodes peripheral disabling symptoms resulting from inflammatory CNS damage. Many RRMS patients transition to chronic course with progressive neurological dysfunctions (secondary MS, SPMS), progression rate varying between and over time. SPMS pathogenesis is now linked immune-cell-mediated processes, although mechanisms...
Neuromyelitis optica (NMO) is an inflammatory disease characterized by recurrent attacks of optic neuritis and myelitis. It generally accepted that autoantibodies against aquaporin 4 water channel protein play a pathogenic role in neuromyelitis optica. We have recently reported plasmablasts are increased the peripheral blood this autoimmune disease, capable producing 4. Here, we demonstrate CD138+HLA-DR+ plasmablasts, subset IgG-producing cells, enriched among cerebrospinal fluid (CSF)...
INTRODUCTION: Consumption of green kiwifruit is known to relieve constipation. Previous studies have also reported improvements in gastrointestinal (GI) comfort. We investigated the effect consuming on GI function and METHODS: Participants included healthy controls (n = 63), patients with functional constipation (FC, n 60), constipation-predominant irritable bowel syndrome (IBS-C, 61) randomly assigned consume 2 kiwifruits or psyllium (7.5 g) per day for 4 weeks, followed by a 4-week...
Multiple sclerosis (MS) is a demyelinating disease of the CNS that presumably mediated by CD4(+) autoimmune T cells. Although both Th1 and Th17 cells have potential to cause inflammatory pathology in rodents, identity pathogenic remains unclear human MS. Given each Th cell subset preferentially expresses specific chemokine receptors, we were interested know whether defined particular receptor profile play an active role pathogenesis In this article, report CCR2(+)CCR5(+) constitute unique...
Background: Fingolimod is an oral drug approved for multiple sclerosis (MS) with ability to trap central memory T cells in secondary lymphoid tissues; however, its variable effectiveness individual patients indicates the need evaluate effects on other cells. Objective: To clarify of fingolimod B-cell populations MS. Methods: We analysed blood samples from 9 fingolimod-treated and 19 control MS by flow cytometry, determine frequencies activation states naive B cells, plasmablasts. Results:...
Resident memory T (Trm) cells are a unique population that can survive and function in compartmentalized tissue with inflammatory potential. We aim to investigate the alteration of Trm acute/chronic neurodegenerative diseases CNS.The frequencies CD4+ CD8+ expressing both CD69 CD103, markers for cells, were quantified peripheral blood CSF (n = 80 44, respectively) cross-sectional manner. The transcriptional profile Trm-like was further analyzed using public single-cell dataset.The frequency...
Abstract Background GGC repeat expansions in NOTCH2NLC are associated with neuronal intranuclear inclusion disease. Very recently, asymptomatic carriers were reported. In these individuals, the CpG island is hypermethylated, suggesting that two factors length and DNA methylation status should be considered to evaluate pathogenicity. Long-read sequencing can used simultaneously profile genomic epigenomic alterations. We analyzed four sporadic cases expansion their phenotypically normal...
Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system that causes damage to myelin sheath as well axonal degeneration. Individuals with MS appear have changes in numbers and functions T-cell subsets, leading immunological imbalance accompanied by enhanced autoreactivity. In previous preclinical studies, (2 S,3 S,4R)-1-O-(α-D-Galactopyranosyl)-N-tetracosanoyl-2-amino-1,3,4-nonanetriol (OCH), a synthetic analog α-galactosylceramide stimulatory for...
Neuromyelitis optica (NMO) is an autoimmune astrocytopathy mediated by anti-AQP4 antibody-producing B cells. Recently, a B-cell subset highly expressing CD11c and T-bet, originally identified as age-associated cells, has been shown to be involved in the pathogenesis of various diseases. The objective this study was determine relationship between frequency
We aimed to determine the association between sarcopenia and frailty in Japan's hyperaged society. investigated incidence of among 423 community-dwelling older adults (304 women 119 men ; mean age : 77.0 years). Interviews, Kihon Checklist (KCL) assessments, physical function tests, anthropometric measurements were performed at baseline. Sarcopenia was defined according Asian Working Group for 2019 criteria, with a KCL score ≥7 indicating frailty. Eight patients (1.9%) had alone, 113 (26.7%)...
On the basis of hypothesis that copy number mutations genes encoding myelin compact proteins are responsible for disorders in humans, we have explored possibility patients with Charcot-Marie-Tooth disease (CMT) whose remain undefined.A family 6 affected members 3 consecutive generations, presenting motor and sensory demyelinating polyneuropathy, was investigated. Characteristic clinical features this pedigree include Adie pupils substantial intrafamilial variability age at onset,...
Neuronal intranuclear inclusion disease (NIID) exhibits diverse clinical phenotypes caused by the intronic repeat expansion of NOTCH2NLC .1,2 An acute encephalopathic episode can manifest in some patients with NIID.3,4 Herein, we report an NIID patient harboring a de novo {(GGA)n(GGC)n}n , who developed abrupt mitochondrial encephalomyopathy, lactic acidosis, and stroke-like (MELAS)-like 15-year course diagnosed as chronic inflammatory demyelinating polyneuropathy (CIDP).
Oculopharyngodistal myopathy (OPDM) is caused by the expansion of CGG repeats in NOTCH2NLC (OPDM_NOTCH2NLC) GIPC1 (OPDM_GIPC1), or LRP12 (OPDM_LRP12). Neuronal intranuclear inclusion disease (NIID) clinically distinct from OPDM but also NOTCH2NLC, which may be an indicator skin biopsy. We investigated presence inclusions biopsies patients with and muscle diseases a similar pathology to evaluate whether they will have diagnostic findings on biopsy.We analysed frequency p62-positive sweat...