A5004022583- Autoimmune Neurological Disorders and Treatments
- Peripheral Neuropathies and Disorders
- Infectious Diseases and Tuberculosis
- Genetics and Neurodevelopmental Disorders
- Herpesvirus Infections and Treatments
- Bacterial Infections and Vaccines
- Spinal Hematomas and Complications
- IgG4-Related and Inflammatory Diseases
- Multiple Sclerosis Research Studies
- Autoimmune and Inflammatory Disorders
- Fungal Infections and Studies
- Myasthenia Gravis and Thymoma
- Sarcoidosis and Beryllium Toxicity Research
- Cardiac tumors and thrombi
- Polyomavirus and related diseases
- Spinal Dysraphism and Malformations
- Vestibular and auditory disorders
- RNA and protein synthesis mechanisms
- Cerebral Venous Sinus Thrombosis
- Immunotherapy and Immune Responses
- Aortic Disease and Treatment Approaches
- Diabetes Management and Education
- Antifungal resistance and susceptibility
- Pneumocystis jirovecii pneumonia detection and treatment
- Pulmonary Hypertension Research and Treatments
National Center of Neurology and Psychiatry
2024-2025
Tokyo Medical and Dental University
2019-2024
Tsuchiura Kyodo General Hospital
2017-2021
Kyoto Prefectural University of Medicine
2021
Chiba Cancer Center
2021
Neuromyelitis optica (NMO) is an autoimmune astrocytopathy mediated by anti-AQP4 antibody-producing B cells. Recently, a B-cell subset highly expressing CD11c and T-bet, originally identified as age-associated cells, has been shown to be involved in the pathogenesis of various diseases. The objective this study was determine relationship between frequency
ABSTRACT Age‐associated B cells (ABCs), initially identified in aged mice, are a distinct cell subset that plays crucial roles autoimmune diseases through the production of autoantibodies, proinflammatory cytokines, and antigen presentation. Although definitive set markers for identifying ABCs has not yet been established, they commonly characterized by expression CD11c, CD11b, transcription factor T‐bet, along with reduced levels CD21, either alone or combination. ABC differentiation is...
Rationale: OSAM is a rare ventriculoperitoneal (VP) shunt complication where cervical spinal cord compression by epidural venous plexus engorgement caused cerebrospinal fluid (CSF) overdrainage. Symmetrically indented deformity of the upper and surrounding are characteristic radiological findings. Both them typically detected on magnetic resonance imaging (MRI) enhanced computed tomography (CT). Patient concerns: The 77-year-old man who underwent placement VP without an antisiphon device to...
Although paradoxical reactions (PRs) to anti-tuberculosis (anti-TB) therapy during treatment are well-established occurrences, PRs presenting as a new lesion after the completion of extremely rare, and little is known about management such cases, particularly central nervous system (CNS) tuberculosis.A 27-year-old female, with past medical history tuberculous meningitis 10 years ago who completed anti-TB asymptomatic remnant tuberculomas in basal cistern, was admitted our hospital because...
A 42-year-old immunocompetent man developed left-sided orbital and temporal stabbing pain, accompanied by ipsilateral lacrimation conjunctival injection with periorbital edema (figure 1A). On day 10, Hutchinson sign, which is defined as zoster skin lesions in the root, dorsum, apex of nose,1 became evident severe keratoconjunctivitis iritis 1B). PCR testing blood revealed varicella-zoster virus he was diagnosed herpes ophthalmicus (HZO). sign indicates involvement nasociliary nerve, a branch...
Objective Cryptococcal meningoencephalitis (CM) causes significant morbidity and mortality in human immunodeficiency virus (HIV)-negative HIV-positive populations. White matter lesions (WMLs) have been reported both populations of CM patients; however, the mechanisms underlying WML formation remain unknown. We herein report relationship between intrathecal immune response development WMLs HIV-negative patients with CM.
Abstract Background Hypertrophic pachymeningitis (HP) is a rare disorder that involves localized or diffuse thickening of the dura mater. HP associated with various inflammatory, infectious, and malignant diseases, such as rheumatic arthritis, sarcoidosis, anti-neutrophil cytoplasmic antibody-associated vasculitis, IgG4-related disorders, syphilis, tuberculosis, bacterial fungal infections, cancer, idiopathic when evaluation fails to reveal cause. Among them, chronic infection...
<h3>Background and Objective</h3> Alexander disease (ALXDRD) is an autosomal dominant neurologic disorder caused by mutations in the glial fibrillary acidic protein (<i>GFAP</i>) gene pathologically defined Rosenthal fiber accumulation. Most are exonic missense mutations, splice site rare. We report a very-late-onset autopsied case of adult-onset ALXDRD with novel mutation. <h3>Methods</h3> Genetic testing <i>GFAP</i> was performed Sanger sequencing. Using brain tissues, transcript analysis...
Abstract Background: Hypertrophic pachymeningitis (HP) is a rare disorder that involves localized or diffuse thickening of the dura mater. HP associated with various inflammatory, infectious, and malignant diseases, such as rheumatic arthritis, sarcoidosis, anti-neutrophil cytoplasmic antibody-associated vasculitis, IgG4-related disorders, syphilis, tuberculosis, bacterial fungal infections, cancer, idiopathic when evaluation fails to reveal cause. Among them, chronic infection...
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Thursday, April 30April 14, 2020Free AccessBilaterally Synchronized Faciobrachial Dystonic Seizures in Anti-LGI1 Encephalitis: A Case Report (1724)Takahisa Mikami, Eiichiro Amano, Takahiro Iizuka, and Akira MachidaAuthors Info & AffiliationsApril 2020 issue94 (15_supplement)https://doi.org/10.1212/WNL.94.15_supplement.1724 Letters to the Editor
Aortic dissection is a rare cause of an acute ischemic stroke or transient attack (TIA). particularly challenging in patients who are eligible for thrombolysis secondary to the diagnostic difficulty within narrow time window (4.5 h) and have risk developing life-threatening hemorrhagic complications following thrombolysis. Computed tomographic angiography (CTA) has been mainstay imaging when evaluating aortic syndrome. However, it cannot be routinely performed pregnant those with renal...