A5000297625- Heart Failure Treatment and Management
- Gut microbiota and health
- Platelet Disorders and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Protease and Inhibitor Mechanisms
- Congenital Heart Disease Studies
- Blood disorders and treatments
- Thyroid Disorders and Treatments
- Blood groups and transfusion
- Effects and risks of endocrine disrupting chemicals
- Blood Coagulation and Thrombosis Mechanisms
- Cardiac Structural Anomalies and Repair
- Air Quality and Health Impacts
- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Ion channel regulation and function
- Aortic aneurysm repair treatments
- Proteoglycans and glycosaminoglycans research
- Cardiac Valve Diseases and Treatments
- T-cell and B-cell Immunology
- Vitamin D Research Studies
- Aortic Disease and Treatment Approaches
- Diet and metabolism studies
- Cardiac pacing and defibrillation studies
- Cardiac Ischemia and Reperfusion
Kobe University
2015-2025
Tokyo Metropolitan Tama-Hokubu Medical Center
2023-2024
Kurashiki Central Hospital
2011-2024
Washington University in St. Louis
2021-2023
The University of Tokyo
1984-2023
Tokyo Institute of Technology
2023
Gifu Pharmaceutical University
2015-2022
Cyberdyne (Japan)
2011-2021
National Cerebral and Cardiovascular Center
2006-2021
Toyama University Hospital
2015-2021
Background: It is increasingly recognized that gut microbiota play a pivotal role in the development of atherosclerotic cardiovascular disease. Previously, we have reported abundance genus Bacteroides lower patients with coronary artery disease (CAD) than without CAD risk factors or healthy volunteers. However, it remains unclear which and how specific bacteria contribute to progression atherosclerosis. Methods: We recruited controls factors. then compared microbial composition using 16S...
Aim: Recent studies have suggested that metabolic disorders such as obesity and type 2 diabetes are associated with gut microbiota. The association between atherosclerosis microbiota has also been attracting increased attention. Our aim was to specify a characteristic trend of in coronary artery disease (CAD).
Gut microbiome composition or circulating microbiome-related metabolites in patients with heart failure (HF) have not been investigated at different time points (i.e., the decompensated (Decomp) and compensated (Comp) phases).
The gut microbiota were shown to play critical roles in the development of atherosclerosis, but detailed mechanism is limited. purpose this study clarify influence on atherogenesis via lipid metabolism and systemic inflammation. Germ-free or conventionally raised (Conv) ApoE-deficient (ApoE-/-) mice fed chow diet euthanized at 20 weeks age. We found that lack ApoE-/- caused a significant increase plasma hepatic cholesterol levels compared with Conv mice. absence changed bile acid composition...
Although T-cell-mediated chronic inflammation contributes to atherosclerosis development, the role of a negative regulatory molecule cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) in is poorly understood. We investigated effects CTLA-4 overexpression on apolipoprotein E-deficient (Apoe(-/-)) mice.We generated transgenic (CTLA-4-Tg)/Apoe(-/-) mice that display constitutive cell surface and intracellular expression T cells assessed at age 16 weeks. significantly reduced atherosclerotic...
Abstract Background Rare neuromuscular diseases such as spinal muscular atrophy, bulbar dystrophy, Charcot-Marie-Tooth disease, distal myopathy, sporadic inclusion body myositis, congenital and amyotrophic lateral sclerosis lead to incurable amyotrophy consequent loss of ambulation. Thus far, no therapeutic approaches have been successful in recovering the ambulatory ability. Thus, aim this trial was evaluate efficacy safety cybernic treatment with a wearable cyborg Hybrid Assistive Limb...
Spleen cells treated with mitogens produce a potent bone-resorbing factor called osteoclast-activating (OAF). To examine the relationship between and other protein factors produced by spleen cells, colony-stimulating (CSF), differentiation-inducing (DIF), macrophage fusion (MFF), growth (MGF) were purified from 2.68 liters of conditioned medium mouse cell cultures concanavalin A. Purification was performed successively DEAE-cellulose, Blue Sepharose, Sephadex G-150 column chromatography...
Abstract Aims Altered thyroid hormone metabolism characterized by a low triiodothyronine (T3), so‐called low‐T3 syndrome, is common finding in patients with severe systemic diseases. Additionally, subclinical dysfunction, defined as abnormal stimulating (TSH) and normal thyroxine (T4), causes left ventricular dysfunction. Our objective was to identify the prevalence prognostic impact of syndrome dysfunction acute decompensated heart failure (ADHF). Methods results We examined 274 ADHF who...
Abstract Faecal lipopolysaccharides (LPS) have attracted attention as potent elements to explain a correlation between the gut microbiota and cardiovascular disease (CVD) progression. However, underlying mechanism of how specific bacteria contribute faecal LPS levels remains unclear. We retrospectively analysed data 92 patients found that abundance genus Bacteroides was significantly negatively correlated with levels. The controls showed higher than in CVD. endotoxin units LPS, determined by...
Inflammatory pseudotumor of the liver is a localized mass consisting fibrous stroma and chronic inflammatory infiltrate without anaplasia. Diagnosis this rare disease important to avoid surgery. The purpose study was determine if CT useful in diagnosis lesion. scans nine patients with proved were reviewed. made by surgical resection three percutaneous biopsy six patients. Six had symptoms laboratory data suggesting active inflammation caused pseudotumor. remaining asymptomatic. performed IV...
Abstract Atrial fibrillation (AF) reduces the quality of life by triggering stroke and heart failure. The association between AF onset gut metabolites suggests a causal relationship microbiota dysbiosis; however, remains poorly understood. We prospectively enrolled 34 hospitalized patients with 66 age-, sex-, comorbidity-matched control subjects without history AF. Gut microbial compositions were evaluated amplicon sequencing targeting 16S ribosomal RNA gene. assessed differences in dietary...
1 alpha,25-Dihydroxyvitamin D3 [1 alpha,25-(OH)2D3] induces fusion of murine alveolar macrophages. This effect was observed in growth medium containing 5% human serum but not the with fetal bovine serum. Unlike alpha,25-(OH)2D3, bacterial lipopolysaccharides (LPS) did induce However, both alpha,25-(OH)2D3 and LPS activated macrophages, as measured by glucose consumption, increase Fc receptors, induction cytotoxicity. The number receptors on surface multinucleated giant cells induced much...
Epidemiologic studies have reported that particulate matter with aerodynamic diameters ≤2.5 μm (PM2.5) affect respiratory diseases, including asthma. The components and/or factors of PM2.5 contribute to the exacerbation asthma not been identified. We investigated effects extracts collected in Japan on and immune systems. was from an industrial area urban December 2013. Airway epithelial cells were exposed aqueous or organic PM2.5. Exposure both areas, especially rather than extracts, caused...
Aims: Circulating amino acid (AA) abnormalities serve as predictors of adverse outcomes in patients with heart failure (HF). However, the role gut microbiota AA disturbances remains unknown. Thus, we investigated microbial functions and their associations metabolic alterations HF. Methods Results: We performed whole-genome shotgun sequencing fecal samples mass spectrometry-based profiling AAs compensated Plasma levels total essential (EAAs) histidine were significantly lower HF than control...
Objective: The global trends in myocarditis burden over the past two decades remain poorly understood and might be increasing during coronavirus disease 2019 (COVID-19) worldwide pandemic. This study aimed to provide comprehensive estimates of incidence, mortality, disability-adjusted life years (DALYs) for globally from 1990 2017. Methods: Data regarding DALY, estimated annual percentage change (EAPC) between 2017 were collected calculated Global Burden Disease study. We additionally...
The role of immune checkpoints in the setting tissue injury remains unknown. Using an experimental model isoproterenol (ISO)-induced stress cardiomyopathy, we show that ISO-induced myocardial provokes tissue-autonomous up-regulation programmed death-1 (PD-1):programmed death ligand (PD-L) axis cardiac resident innate cells and T cells. PD-1 signaling was responsible for modulating acute inflammatory response, as well normalization impaired left ventricular structure function after ISO...
UVB irradiation is an established treatment for immunoinflammatory cutaneous disorders and has been shown to suppress systemic inflammatory diseases through modulation of the adaptive immune response. However, it remains unknown whether prevents disease arteries such as atherosclerosis.Here, we show that exposure inhibits development progression atherosclerosis in atherosclerosis-prone mice by expanding enhancing functional capacity CD4+ forkhead box P3+ regulatory T cells regulating...
Abstract Background Previously, we have reported that daily glucose fluctuations could affect coronary plaque vulnerability, but the underlying mechanisms remained unclear. This study sought to investigate impact of CD14 ++ CD16 + monocytes on as assessed by virtual histology intravascular ultrasound (VH-IVUS), well their relationship fluctuating levels in patients with asymptomatic artery disease (CAD). Methods Fifty-one CAD, who were undergoing lipid-lowering therapy and underwent VH-IVUS...
Bacteroides vulgatus and B. dorei have a protective effect against atherosclerosis, suggesting that expansion of these species in the gut microbiota could help patients with coronary artery disease (CAD). This study aimed to investigate resistant starch (RS) on its metabolites fecal sample cultures from CAD individuals without CAD, using single-batch fermentation system.Fecal samples 11 10 were fermented for 30 h or RS Kobe University Human Intestinal Microbiota Model (KUHIMM). Gut abundance...
Amiodarone is associated with a number of significant adverse effects, including elevated transaminase levels, pulmonary fibrosis, arrhythmia, and thyroid dysfunction. Although dysfunction considered to be common potentially serious effect amiodarone therapy, the exact pathogenesis remains unknown because its complex manifestations. Therefore, prevalence of, risk factors for, amiodarone-induced in Japanese patients were investigated present study.A retrospective analysis treated between...
MEPS Marine Ecology Progress Series Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout JournalEditorsTheme Sections 344:277-297 (2007) - DOI: https://doi.org/10.3354/meps06873 Provisioning strategies of Antarctic fur seals and chinstrap penguins produce different responses distribution common prey habitat Taro Ichii1,*, John L. Bengtson2, Peter Boveng2, Yoshimi Takao3, K. Jansen2, Lisa M. Hiruki-Raring2, Michael F....
Methyl paraben (MP) is often used as a preservative in foods, drugs, and cosmetics because of its high reliability safety based on the rapid excretion nonaccumulation following administration. Light irradiation sometimes produces unexpected activity from chemicals such MP; furthermore, there ample opportunity for MP to be exposed sunlight. Here, we investigated whether shows DNA damage after sunlight irradiation. Two major photoproducts, p-hydroxybenzoic acid (PHBA) 3-hydroxy methyl...