A5101667744- Aortic aneurysm repair treatments
- Rheumatoid Arthritis Research and Therapies
- Vasculitis and related conditions
- T-cell and B-cell Immunology
- Aortic Disease and Treatment Approaches
- Peripheral Artery Disease Management
- Cardiac, Anesthesia and Surgical Outcomes
- Systemic Lupus Erythematosus Research
- Abdominal vascular conditions and treatments
- Immune Cell Function and Interaction
- Atherosclerosis and Cardiovascular Diseases
- Colorectal and Anal Carcinomas
- Vascular Procedures and Complications
- Infectious Aortic and Vascular Conditions
- Angiogenesis and VEGF in Cancer
- Chronic Lymphocytic Leukemia Research
- Nutrition and Health in Aging
- Lymphoma Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Colorectal Cancer Treatments and Studies
- Muscle and Compartmental Disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Colorectal Cancer Surgical Treatments
- Cardiac tumors and thrombi
- Vascular anomalies and interventions
Kensei Hospital
2020-2025
Ehime University
2013-2024
Jikei University School of Medicine
2024
The University of Tokyo
2024
Jikei University Kashiwa hospital
2024
Society for Vascular Surgery
2023
Kanto Gakuin University
2022-2023
University of New Haven
2023
Tokyo Metropolitan Tama Medical Center
2022
Saiseikai Yahata General Hospital
2022
Aim: Recent studies have suggested that metabolic disorders such as obesity and type 2 diabetes are associated with gut microbiota. The association between atherosclerosis microbiota has also been attracting increased attention. Our aim was to specify a characteristic trend of in coronary artery disease (CAD).
Abstract Purpose: Positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) has been widely used in the management of colorectal cancer (CRC). However, relationship between FDG accumulation and KRAS/BRAF mutations not yet investigated. The purpose this study was to investigate whether affect CRC. Experimental Design: Retrospective analysis conducted 51 patients CRC who underwent FDG-PET/computed tomographic (CT) scans for staging before primary tumor resection. maximum...
Abstract Human peripheral CD4+CD25− T cells can be induced to express Foxp3 when activated in vitro by TCR stimulation with TGF-β and IL-2. However, these TGF-β–induced Foxp3+ regulatory (iTregs) lack a phenotype. From libraries of nuclear receptor ligands bioactive lipids, we screened three peroxisome proliferator-activated (PPAR)α (bezafibrate, GW7647, 5,8,11,14-eicosatetraynoic acid) two PPARγ agonists (ciglitazone 15-deoxy-Δ-12,14-PG J2) as molecules that increased expression human...
Targeted proteomics, which involves quantitative analysis of targeted proteins using selected reaction monitoring (SRM) mass spectrometry, has emerged as a new methodology for discovery clinical biomarkers. In this study, we used serum proteomics to identify circulating biomarkers prediction disease activity and organ involvement in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).A large-scale SRM assay targeting 135 biomarker candidates was established...
Background and Purpose— Aging is a major risk for stroke highly complex biological process believed to involve multiple mechanisms. Mutant mice that express low levels of the spindle assembly checkpoint protein BubR1 are known develop several aging-associated phenotypes at very young age, including cataracts, lordokyphosis, loss subcutaneous fat, impaired wound healing. However, whether acts prevent vascular aging has not yet been established. The present study was designed investigate...
We here report the results of a Phase I/IIa open-label four dose-escalation clinical study assessing safety, tolerability, and possible therapeutic efficacy single intramuscular administration DVC1-0101, new gene transfer vector based on nontransmissible recombinant Sendai virus (rSeV) expressing human fibroblast growth factor-2 (FGF-2) (rSeV/dF-hFGF2), in patients with peripheral arterial disease (PAD). Gene was done 12 limbs rest pain, three them had ischemic ulcer(s). No cardiovascular or...
BACKGROUND: The management of asymptomatic primary tumor in patients with unresectable metastatic colorectal cancer remains inconsistent. OBJECTIVE: This study aimed to determine the rate symptom-directed surgery after systemic chemotherapy and estimate impact initial resection on survival an tumor. DESIGN: was a single-institution, retrospective observational study. SETTINGS: conducted tertiary referral hospital. PATIENTS: Between 2005 2011, 191 consecutive newly diagnosed stage IV were...
Background:The protective function of regulatory T cells (Treg) has been identified in experimental atherosclerosis, but the contribution Tregto pathogenesis human coronary artery disease (CAD) remains poorly understood. We investigated Tregand T-cell/effector T-cell (Treg/Teff) ratio peripheral blood samples from CAD patients using a new strategy for precise identification Treg.Methods and Results:Peripheral were collected 73 stable (55 middle-aged 18 old patients) 64 controls (47 17 young...
The aim of this study was to assess the effects soluble sialic acid-binding immunoglobulin-type lectin (sSiglec)-9 on joint inflammation and destruction in a murine collagen-induced arthritis (CIA) model monolayer cultures macrophages (RAW264.7 cells peritoneal macrophages) fibroblast-like synoviocytes (FLS) derived from patients with rheumatoid arthritis. DBA/1J mice were immunized type II collagen. Effects sSiglec-9 evaluated using physiologic score, histological analysis, serum tumor...
UVB irradiation is an established treatment for immunoinflammatory cutaneous disorders and has been shown to suppress systemic inflammatory diseases through modulation of the adaptive immune response. However, it remains unknown whether prevents disease arteries such as atherosclerosis.Here, we show that exposure inhibits development progression atherosclerosis in atherosclerosis-prone mice by expanding enhancing functional capacity CD4+ forkhead box P3+ regulatory T cells regulating...
<h3>Importance</h3> Postoperative health care–associated infections are associated with a greater deterioration in patients' general status and social economic burden, at least 1 occurring approximately 4% of acute care hospital patients. Antimicrobial prophylaxis prevents surgical site various orthopedic procedures; however, its relationship remains unknown. <h3>Objective</h3> To examine whether shorter antimicrobial duration less than 24 hours after surgery is not inferior to longer...
Abstract Vascular inflammation via T-cell-mediated immune responses has been shown to be critically involved in the pathogenesis of abdominal aortic aneurysm (AAA). T-cell coinhibitory molecule cytotoxic T-lymphocyte–associated antigen-4 (CTLA-4) is known act as a potent negative regulator responses. However, role this development AAA remains completely unknown. We determined effects CTLA-4 overexpression on experimental AAA. continuously infused transgenic (CTLA-4-Tg)/apolipoprotein...
Objectives Hydroxychloroquine (HCQ) has been shown to reduce thrombotic events in patients with SLE. However, the antiplatelet effects of HCQ are only supported by platelet aggregation assay, which is a non-physiological test. The total thrombus-formation analysis system (T-TAS) microchip-based flow chamber that mimics physiological conditions and allows for quantitative thrombogenicity. present study investigated using T-TAS. Methods This was single-centre cross-sectional on 57 We measured...
Abstract Objective The present non-inferiority study was designed to compare the effect of discontinuing versus continuing methotrexate (MTX) alongside certolizumab pegol (CZP) on maintaining low disease activity (LDA) in rheumatoid arthritis (RA) patients already stable combination therapy. Methods This multicentre, open-label, randomised, controlled trial included RA with sustained LDA (Clinical Disease Activity Index [CDAI] ≤ 10) for ≥ 12 weeks CZP + MTX. Patients were randomised 1:1 by...