A5076422953- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Lipid metabolism and disorders
- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer, Lipids, and Metabolism
- Regulation of Appetite and Obesity
- Biomarkers in Disease Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Blood properties and coagulation
- Cholesterol and Lipid Metabolism
- Peroxisome Proliferator-Activated Receptors
- Liver Disease Diagnosis and Treatment
- Angiogenesis and VEGF in Cancer
- Cell Adhesion Molecules Research
- Apelin-related biomedical research
- Ion Transport and Channel Regulation
- Metabolism, Diabetes, and Cancer
- Hormonal Regulation and Hypertension
- Lymphatic System and Diseases
- Cardiac Imaging and Diagnostics
- Systemic Lupus Erythematosus Research
- Caveolin-1 and cellular processes
- Diet, Metabolism, and Disease
University of Copenhagen
2023-2025
Osaka University
2015-2024
University of Auckland
2018-2024
MacDiarmid Institute for Advanced Materials and Nanotechnology
2018-2024
Victoria University of Wellington
2024
Hyogo Prefectural Nishinomiya Hospital
2018-2023
Australian Nuclear Science and Technology Organisation
2020-2021
Flinders University
2020-2021
Utrecht University
2021
Maurice Wilkins Centre
2021
Abstract —Adiponectin is a novel, adipose-specific protein abundantly present in the circulation, and it has antiatherogenic properties. We analyzed plasma adiponectin concentrations age- body mass index (BMI)–matched nondiabetic type 2 diabetic subjects with without coronary artery disease (CAD). Plasma levels of CAD were lower than those (6.6±0.4 versus 7.9±0.5 μg/mL men, 7.6±0.7 11.7±1.0 women; P <0.001). The patients (4.0±0.4 6.6±0.4 μg/mL, <0.001 men; 6.3±0.8 women). In contrast,...
Among the many adipocyte-derived endocrine factors, we recently found an adipocyte-specific secretory protein, adiponectin, which was decreased in obesity. Although obesity is associated with increased cardiovascular mortality and morbidity, molecular basis for link between vascular disease has not been fully clarified. The present study investigated whether adiponectin could modulate endothelial function relate to coronary disease.For vitro study, human aortic cells (HAECs) were...
Fat tissue produces a variety of secreted proteins (adipocytokines) with important roles in metabolism. We isolated newly identified adipocytokine, visfatin, that is highly enriched the visceral fat both humans and mice whose expression level plasma increases during development obesity. Visfatin corresponds to protein previously as pre–B cell colony-enhancing factor (PBEF), 52-kilodalton cytokine expressed lymphocytes. exerted insulin-mimetic effects cultured cells lowered glucose levels...
Background —Among the many adipocyte-derived endocrine factors, we found an plasma protein, adiponectin, that was decreased in obesity. We recently demonstrated adiponectin inhibited tumor necrosis factor-α (TNF-α)–induced expression of endothelial adhesion molecules and level reduced patients with coronary artery disease ( Circulation . 1999;100:2473–2476). However, intracellular signal by which suppressed molecule not elucidated. The present study investigated mechanism modulation for...
Insulin resistance and its dreaded consequence, type 2 diabetes, are major causes of atherosclerosis. Adiponectin is an adipose-specific plasma protein that possesses anti-atherogenic properties, such as the suppression adhesion molecule expression in vascular endothelial cells cytokine production from macrophages. Plasma adiponectin concentrations decreased obese diabetic subjects with insulin resistance. A regimen normalizes or increases might prevent atherosclerosis patients In this...
Adiponectin is an adipocyte-derived plasma protein that accumulates in the injured artery and has potential antiatherogenic properties. This study was designed to determine whether a decreased adiponectin level (hypoadiponectinemia) can be independently associated with prevalence of coronary disease (CAD). The consecutive 225 male patients were enrolled from inpatients who underwent angiography. Voluntary blood donors (n=225) matched for age served as controls. Plasma levels CAD...
Background —Excessive lipid accumulation in macrophages plays an important role the development of atherosclerosis. Recently, we discovered adipocyte-specific plasma protein, adiponectin, that is decreased patients with coronary artery disease. We previously demonstrated adiponectin acts as a modulator for proinflammatory stimuli and inhibits monocyte adhesion to endothelial cells. The present study investigated effects on human monocyte-derived macrophages. Methods Results —Human monocytes...
Dysregulation of adipocyte-derived bioactive molecules plays an important role in the development atherosclerosis. We previously reported that adiponectin, adipocyte-specific plasma protein, accumulated injured artery from and suppressed endothelial inflammatory response vascular smooth muscle cell proliferation, as well macrophage-to-foam transformation vitro. The current study investigated whether increased adiponectin could actually reduce atherosclerosis vivo.Apolipoprotein E-deficient...
Background— High-sensitive C-reactive protein (hs-CRP) is a well-known risk factor for coronary artery disease (CAD). Recently, we have demonstrated that adiponectin served as an antiatherogenic plasma which was secreted specifically from adipocytes. The present study investigated the association between and CRP in blood stream adipose tissue. Methods Results— We studied total of 101 male patients, 71 whom had angiographically documented atherosclerosis. As control group, 30 patients with...
Adiponectin, an adipose-specific secretory protein, exhibits antidiabetic and antiatherogenic properties. In the present study, we examined effects of sex hormones on regulation adiponectin production. Plasma concentrations were significantly lower in 442 men (age, 52.6 +/- 11.9 years [mean SD]) than 137 women (53.2 12.0 years) but not different between pre- postmenopausal women. mice, ovariectomy did alter plasma levels. contrast, high levels found castrated mice. Testosterone treatment...
Obesity is more linked to vascular disease, including atherosclerosis and restenotic change, after balloon angioplasty. The precise mechanism linking obesity disease still unclear. Previously we have demonstrated that the plasma levels of adiponectin, an adipose-derived hormone, decreases in obese subjects, hypoadiponectinemia associated ischemic heart disease. In current study, investigated vivo role adiponectin on neointimal thickening artery injury using adiponectin-deficient mice...
ABSTRACT. Adiponectin (ADPN), which is a secretory protein of adipose tissue, attenuates endothelial inflammatory responses in vitro. Among human subjects, plasma ADPN concentrations are reduced among patients with atherosclerotic complications but substantially increased advanced renal failure. The clinical and biochemical correlates levels were investigated the predictive power respect to survival rates cardiovascular events was prospectively tested cohort 227 hemodialysis patients, who...
The metabolic syndrome, a cluster of abdominal obesity, dyslipidemia, hypertension and hyperglycemia, is common basis for atherosclerotic vascular diseases in industrial countries exposed to overnutrition. Adiponectin an adipose-derived plasma protein with anti-atherogenic insulin-sensitizing activities.A total 661 Japanese adults (479 men, 53+/-10 years; 182 women 56+/-10 years) were enrolled. Plasma adiponectin concentrations correlated negatively waist circumference, visceral fat area,...
Adiponectin is an adipocyte-specific adipocytokine with anti-atherogenic and anti-diabetic properties. Here, we investigated whether adiponectin regulates angiogenic processes in vitro vivo. stimulated the differentiation of human umbilical vein endothelium cells (HUVECs) into capillary-like structures functioned as a chemoattractant migration assays. promoted phosphorylation AMP-activated protein kinase (AMPK), Akt/protein B, endothelial nitric oxide synthesis (eNOS) HUVECs. Transduction...
Obesity is a risk factor for the development of many severe human diseases such as cardiovascular disorders, diabetes, and cancer, which are tightly linked to angiogenesis. The adipose tissue produces several growth factors/hormones including leptin, tumor necrosis α, adiponectin. It has been found that adiponectin levels reduced in obesity. Here, we report unique function negative regulator In vitro , potently inhibits endothelial cell proliferation migration. chick chorioallantoic membrane...
Background — Vascular smooth muscle cell proliferation plays an important role in the development of atherosclerosis. We previously reported that adiponectin, adipocyte-specific plasma protein, accumulated human injured artery and suppressed endothelial inflammatory response as well macrophage-to-foam transformation. The present study investigated effects adiponectin on migration aortic cells (HASMCs). Methods Results HASMC was estimated by [ 3 H] thymidine uptake number. Cell assay...
Revisions 1. CQs and Systematic Review (SR)In the subsections on dyslipidemia in assessment of risk factors, absolute ASCVD, lipid management targets as well drug therapy diet improving lifestyle habits, we created performed an SR based MINDS method.For our SR, essentially chose literature published before end 2015. Calculation Absolute RiskFollowing 2012 version, has been using calculation described this set guidelines.The NIPPON DATA80, which was used to calculate result baseline surveys...
Adiponectin is an adipocyte-derived, antiatherogenic protein that present in serum as three isoforms. Total adiponectin levels are decreased obese or diabetic humans animal models. This study was designed to elucidate the relative isoform distribution of human disease states and identify active form toward vascular endothelial cells. The percentage high molecular weight (HMW) per total significantly lower patients with coronary artery than control subjects, whereas hexamer similar trimer...