A5032859480- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Acute Myocardial Infarction Research
- Sex and Gender in Healthcare
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Receptor Mechanisms and Signaling
- ECG Monitoring and Analysis
- Insect and Pesticide Research
- Neuroscience and Neural Engineering
- Insect Resistance and Genetics
- Cardiac Health and Mental Health
- Lipoproteins and Cardiovascular Health
- Heart Failure Treatment and Management
- Cardiac pacing and defibrillation studies
- Cardiomyopathy and Myosin Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Electrostatic Discharge in Electronics
- Bacteriophages and microbial interactions
- Biotechnology and Related Fields
- Cardiac Structural Anomalies and Repair
- Venous Thromboembolism Diagnosis and Management
- Genetically Modified Organisms Research
- Cardiac, Anesthesia and Surgical Outcomes
- Autopsy Techniques and Outcomes
Hospital Italiano de Buenos Aires
2022
Cardiovascular Research Foundation
2013-2015
Icahn School of Medicine at Mount Sinai
2011-2015
Masonic Medical Research Laboratory
2005-2012
Amsterdam UMC Location University of Amsterdam
2009
University of Szeged
2009
University of Louisville
2009
Hungarian Academy of Sciences
2009
Danish National Research Foundation
2008
University of Copenhagen
2008
Cardiac ion channelopathies are responsible for an ever-increasing number and diversity of familial cardiac arrhythmia syndromes. We describe a new clinical entity that consists ST-segment elevation in the right precordial ECG leads, shorter-than-normal QT interval, history sudden death.Eighty-two consecutive probands with Brugada syndrome were screened channel gene mutations direct sequencing. Site-directed mutagenesis was performed, CHO-K1 cells cotransfected cDNAs encoding wild-type or...
Background— Sudden cardiac death takes the lives of more than 300 000 Americans annually. Malignant ventricular arrhythmias occurring in individuals with structurally normal hearts account for a subgroup these sudden deaths. The present study describes genetic basis new clinical entity characterized by and short-QT intervals ECG. Methods Results— Three families hereditary syndrome high incidence were studied. In 2 them, we identified different missense mutations resulting same amino acid...
The Brugada Syndrome (BrS), an inherited syndrome associated with a high incidence of sudden cardiac arrest, has been linked to mutations in four different genes leading loss function sodium and calcium channel activity. Although the transient outward current (I(to)) is thought play prominent role expression syndrome, I(to)-related have not identified as yet.One hundred five probands BrS were screened for ion gene using single strand conformation polymorphism (SSCP) electrophoresis direct...
Background— Brugada syndrome, characterized by ST-segment elevation in the right precordial ECG leads and development of life-threatening ventricular arrhythmias, has been associated with mutations 6 different genes. We identify characterize a mutation new gene. Methods Results— A 64-year-old white male displayed type 1 V1 V2 during procainamide challenge. Polymerase chain reaction-based direct sequencing was performed using candidate gene approach. missense (L10P) detected exon SCN3B , β3...
The Brugada syndrome is an arrhythmogenic disease caused in part by mutations the cardiac sodium channel gene, SCN5A. electrocardiographic pattern characteristic of dynamic and often absent affected individuals. Sodium blockers are effective unmasking carriers disease. However, value test remains controversial.We studied 147 individuals representing 4 large families with SCN5A mutations. Of these, 104 were determined to be at possible risk for underwent both genetic evaluation. Twenty-four...
Mosquitocidal Bacillus thuringiensis strains show as a common feature the presence of toxic proteins with cytolytic and hemolytic activities, Cyt1Aa1 being characteristic toxin subsp. israelensis. We have detected another cyt gene in this subspecies, highly homologous to cyt2An1, coding for 29-kDa from B. kyushuensis. This gene, designated cyt2Ba1, maps upstream cry4B 130-kDa crystal toxin, on 72-MDa plasmid strain 4Q2-72. Sequence analysis revealed, remarkable feature, 5' mRNA stabilizing...
ABSTRACT In the same way that cry genes, coding for larvicidal delta endotoxins, constitute a large and diverse gene family, cyt genes hemolytic toxins seem to compose another set of highly related in Bacillus thuringiensis . Although occurrence Cyt factors B. has been typically associated with mosquitocidal strains, we have recently shown are also present strains different pathotypes; this is case morrisoni subspecies, which includes biologically active against dipteran, lepidopteran,...
Background: Inherited loss of function mutations in SCN5A have been linked to overlapping syndromes including cardiac conduction disease and Brugada syndrome (BrS). The mechanisms responsible for the development one without other are poorly understood. Methods: Direct sequencing was performed a family with disease. Wild-type (WT) mutant channels were expressed TSA201 cells electrophysiological study. Green fluorescent protein (GFP)-fused WT or genes used assess channel trafficking. Results:...
Contrast-induced acute kidney injury (CI-AKI) may occur after percutaneous coronary intervention (PCI).We evaluated patients with ST-elevation myocardial infarction (STEMI) undergoing emergency PCI serial biomarkers.Of the 390 enrolled in HORIZONS-AMI biomarker substudy, 56 (14.3%) developed AKI. In AKI group, levels of B-type natriuretic peptide were consistently higher than no-AKI group at baseline (P = 0.0327), hospital discharge 0.0002), 30-day follow-up 0.0193), and 1-year 0.031). At...
Introduction: Long QT Syndrome (LQTS) is an inherited disorder characterized by prolonged intervals and life‐threatening polymorphic ventricular tachyarrhythmias. LQT1 caused KCNQ1 mutations the most common form of LQTS. Methods Results: Patients diagnosed with LQTS were screened for disease‐associated in KCNQ1, KCNH2, KCNE1, KCNE2, KCNJ2, SCN5A . A novel mutation was identified a three‐base deletion at position 824–826, predicting phenylalanine codon 275 segment 5 (ΔF275). Wild‐type (WT)...
ABSTRACT We cloned and sequenced a new cytolysin gene from Bacillus thuringiensis subsp. medellin . Three IS 240 -like insertion sequence elements the previously cyt1Ab p21 genes were found in vicinity of gene. The encodes protein 29.7 kDa size that is 91.5% identical to Cyt2Ba israelensis has been designated Cyt2Bc. Inclusions containing Cyt2Bc purified crystal-negative strain SPL407 B. reacted weakly with antibodies directed against was not recognized by an antiserum reference Cyt1Aa....
Routine scheduled angiographic follow-up (SAF) after percutaneous coronary intervention (PCI) has been associated with a higher rate of target vessel revascularization (TVR). Its benefits are not known. SAF at 13 months ST-segment elevation myocardial infarction (STEMI) was planned in the first 1,800 successfully stented patients enrolled Harmonizing Outcomes RevascularIZatiON and Stents Acute Myocardial Infarction (HORIZONS-AMI) trial. We compared outcomes without 1 year (before SAF) 3...