A5102740089- Lymphoma Diagnosis and Treatment
- Kawasaki Disease and Coronary Complications
- Coronary Artery Anomalies
- Acute Lymphoblastic Leukemia research
- CNS Lymphoma Diagnosis and Treatment
- Renal Diseases and Glomerulopathies
- Cardiac electrophysiology and arrhythmias
- Medical Imaging Techniques and Applications
- Lung Cancer Treatments and Mutations
- Vasculitis and related conditions
- Renal function and acid-base balance
- Ion channel regulation and function
- Cardiovascular Issues in Pregnancy
- Mechanical Circulatory Support Devices
- Childhood Cancer Survivors' Quality of Life
- Chronic Kidney Disease and Diabetes
- Neuroblastoma Research and Treatments
- Healthcare Systems and Practices
- Cancer-related gene regulation
- Traditional Chinese Medicine Analysis
- Diverticular Disease and Complications
- Nanoplatforms for cancer theranostics
- Neurological disorders and treatments
- Sepsis Diagnosis and Treatment
- Lipid metabolism and disorders
Children's Oncology Group
2020-2025
University of Florida
2020-2025
Xi'an Jiaotong University
2025
First Affiliated Hospital of Xi'an Jiaotong University
2025
Wuxi People's Hospital
2023
Nanjing Medical University
2023
Tongren Hospital
2023
Shanghai Jiao Tong University
2023
Henan Provincial People's Hospital
2022
Zhengzhou University
2022
Background— Sudden cardiac death takes the lives of more than 300 000 Americans annually. Malignant ventricular arrhythmias occurring in individuals with structurally normal hearts account for a subgroup these sudden deaths. The present study describes genetic basis new clinical entity characterized by and short-QT intervals ECG. Methods Results— Three families hereditary syndrome high incidence were studied. In 2 them, we identified different missense mutations resulting same amino acid...
Background— Loss-of-function mutations in SCN5A have been associated with the Brugada syndrome. We report first syndrome family compound heterozygous . The proband inherited 1 mutation from each parent and transmitted to daughter. Methods Results— effects of on function sodium channel were evaluated heterologous expression TSA201 cells, patch-clamp study, confocal microscopy. Genetic analysis revealed that carried 2 missense (P336L I1660V) separate alleles. He displayed a coved-type...
Background Poor glycemic control early in the course of type 1 diabetes mellitus (T1DM) increases risk for microvascular complications. However, predictors deteriorating after diagnosis have not been described, making it difficult to identify high-risk patients and proactively provide aggressive interventions. Objective We examined whether diagnostic age, gender, race were associated with during first 5 years diagnosis. Participants 2218 pediatric T1DM. Methods conducted a longitudinal...
Although the specific etiology of Henoch-Schonlein purpura (HSP) is still unknown, several kinds infectious triggers have been proved to participate in its pathogenesis. The objectives present study were analyze association with childhood HSP Anhui province, China.1200 children recruited from January 2015 December 2017. Serum antistreptolysin O titer, TORCH, Epstein-Barr virus, helicobacter pylori (HP), Mycoplasma antibodies (MP-Ab), tubercle bacillus antibody (TB-Ab), respiratory pathogens...
ABSTRACT A better understanding of positron emission tomography (PET) response in nodular lymphocyte‐predominant Hodgkin lymphoma (nLPHL) is critical for incorporating PET into prospective trials. scans from Children's Oncology Group study AHOD03P1 patients less than 22 years with low‐risk nLPHL, treated three cycles doxorubicin, vincristine, prednisone, and cyclophosphamide chemotherapy, were retrospectively reviewed assigned Deauville 5‐point scale (5PS) scores. Five‐year post‐PET...
Lactate-to-albumin ratio (LAR) is an emergency predictive indicator of sepsis-related mortality. An elevated LAR associated with poor outcomes in critically ill patients. However, its value for acute kidney injury (AKI) patients sepsis remains unclear. Therefore, this study aimed to investigate the relationship between and AKI sepsis. The population was derived from Medical Information Mart Intensive Care-IV (2.0) database stratified into quartiles based on LAR. primary endpoint occurrence...
10019 Background: The reported incidence of second malignant neoplasms (SMN) in long-term survivors Hodgkin lymphoma (HL) is derived from patients treated with outdated radiation therapy (RT) techniques. We modeled the risk SMN pediatric high-risk classic HL modern mediastinal RT. Methods: In who received RT on Children’s Oncology Group study AHOD1331, we lifetime attributable (LAR) at 70 years age thyroid, lung, and breast carcinoma. This value indicates absolute increased due to RT, above...
This study intends to investigate the effects of miR-142-5p encapsulated by serum-derived extracellular vesicles (EVs) on septic acute lung injury (ALI) following remote ischemic preconditioning (RIPC) through a PTEN-involved mechanism. ALI was induced in rats lipopolysaccharide (LPS) injection, 24 h before which RIPC performed via left lower limb. Next, binding affinity between and PTEN identified. EVs were isolated from serum injected into rats. The morphology tissues, pulmonary edema,...
Abstract Background Kawasaki disease (KD) is an acute, self‐limited vasculitis. Coronary artery aneurysm (CAA) serves as a major contributor to the long‐term prognosis of KD. In addition, acute KD usually also leads several kinds noncoronary cardiac abnormalities (NCA) involving pericardium, myocardium and endocardium. Materials methods A total 142 Chinese children with were recruited from July 2015 April 2018. Blood samples collected at 24 hours pre‐intravenous immunoglobulin (IVIG)...
Abstract Alcoholic hepatitis (AH), a kind of alcoholic liver disease, shows poor prognosis. Long noncoding RNAs (lncRNAs) exert critical role in diseases. Here, we intended to investigate the possible molecular mechanism that 1700020I14Rik-based regulation microRNA (miR)-137/Aldo-keto reductase family 1 member B10 (AKR1B10) affecting inflammatory response and hepatocyte damage AH. AH-related genes down-stream regulatory pathway were screnned by bioinformatics. Mouse normal cell line AML12...
Henoch-Schönlein purpura (HSP) is a common autoimmune vasculitis in childhood. The detailed pathogenesis of HSP still unclear, whereas several types predisposing factors have been proved to be the initial step. objectives present study were analyze distribution factors, association with clinical manifestations and relapse/recurrence. 1200 children recruited between January 2015 December 2017. We reviewed their laboratory tests medical histories associated onset. annual incidence was...
In the last decade, incomplete Kawasaki disease (KD), intravenous immunoglobulin (IVIG) non-response and coronary artery abnormalities (CAA) have experienced increasing trends in China. addition, enhancement of pediatricians' awareness may also raise diagnostic rate KD stimulate more aggressive initial therapy acute episode KD. Given this background, we hypothesize that time option IVIG treatment should be parallel with peak systemic inflammation; either earlier or later affect clinical...
Abstract Background Accurate classification of coronary artery abnormalities (CAAs) is essential for clinical decision‐making and long‐term management in Kawasaki disease (KD) patients. To date, there are several echocardiographic criteria CAA assessment. Materials methods The Japanese Ministry Health (JMH) the Z ‐score from 2004 American Heart Association guidelines were adopted their detective efficacies CAAs compared 251 Chinese patients with KD scores calculated by 6 published methods....
Hand, foot and mouth disease (HFMD) is a common infectious among children, caused primarily by human enterovirus-A71 (EV-A71) coxsackievirus-A16 (CV-A16). To date, only two case reports mention that renal involvement can be secondary to or coexisting with CV-A16-associated HFMD. In the present report, we describe 10-year-old girl who was infected EV-A71 subsequently developed definite acute kidney injury (AKI), mainly based on characteristic rash, virus isolation, eyelid edema, hypertension,...
Abstract Purpose/objective We compared the prognostic value of chest radiograph (CXR)‐ and computed tomography (CT)‐derived definition large mediastinal adenopathy (LMA) in pediatric Hodgkin lymphoma (HL). Materials/methods Total 143 patients treated for stage IIIB/IVB HL on COG AHOD0831 were included this study. Six definitions LMA investigated: (i) mass ratio CXR (MR ) > 1/3; (ii) CT (iii) volume (MV 200 mL; (iv) normalized /thoracic diameter [TD]) 1 mL/mm; (v) (MD 10 cm; (vi) /TD) 1/3....
Acute kidney injury (AKI) is a severe and frequent complication of sepsis that occurs in intensive care units with inflammation rapid decline renal function as the main pathological features. Systemic inflammation, microvascular dysfunction, tubule are causes sepsis-induced AKI (SI-AKI). The high prevalence death rate from SI-AKI great challenge for clinical treatment worldwide. However, addition to hemodialysis, there no effective drug improve tissue damage alleviate function. We conducted...
Readmission shortly after discharge is indicative of an increased disease severity for patients with ulcerative colitis (UC) and ineffectiveness to medical therapy, which may contribute a dismal prognosis.This study aimed explore prognostic variables nomogram predict unplanned UC-related readmission within 1 year discharge.A retrospective cohort study.Electronic records all UC treated at our center between January 2014 31 June 2021 were reviewed. A comprehensive analysis various...
Liu, Fei MD; Wang, Jing Wu, Yue Hui Hu, Peng MD, PhDAuthor Information