A5000172588- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Lymphoma Diagnosis and Treatment
- Family Support in Illness
- Adolescent and Pediatric Healthcare
- Hematopoietic Stem Cell Transplantation
- Economic and Financial Impacts of Cancer
- Cancer survivorship and care
- Hemoglobinopathies and Related Disorders
- Lung Cancer Treatments and Mutations
- Palliative Care and End-of-Life Issues
- Multiple and Secondary Primary Cancers
- Acute Myeloid Leukemia Research
- Health Systems, Economic Evaluations, Quality of Life
- Family and Patient Care in Intensive Care Units
- Family and Disability Support Research
- Global Cancer Incidence and Screening
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Chemotherapy-induced cardiotoxicity and mitigation
- Multiple Myeloma Research and Treatments
- Cancer Treatment and Pharmacology
- Neutropenia and Cancer Infections
- Cancer-related cognitive impairment studies
- Pharmaceutical studies and practices
Tufts Medical Center
2016-2025
Tufts University
2016-2025
Institute of Clinical Research
2012-2024
Baim Institute for Clinical Research
2024
Sylvester Comprehensive Cancer Center
2024
Fred Hutch Cancer Center
2024
City Of Hope National Medical Center
2024
Moffitt Cancer Center
2024
Prisma Health
2024
City of Hope
2024
The lack of standardized criteria for quantitative measurement therapeutic response in clinical trials poses a major obstacle the development new agents chronic graft-versus-host disease (GVHD). This consensus document was developed to address several objectives be used GVHD-related trials. proposed measures should practical use both by transplantation and nontransplantation medical providers, adaptable adults children, focused on most important GVHD manifestations. also give preference...
Over the past four decades, allogeneic hematopoietic cell transplantation (alloHCT) has evolved as a curative modality for patients with hematologic diseases. This study describes changes in use, technique, and survival population-based cohort.The included 38,060 malignancies or disorders who underwent first alloHCT US Canadian center from 1994 to 2005 were reported Center International Blood Marrow Transplant Research.AlloHCT treatment acute lymphoblastic (ALL) myeloid leukemias (AML),...
Advances in hematopoietic cell transplantation (HCT) have led to an increasing number of transplant survivors. To adequately support their healthcare needs, there is a need know the prevalence HCT We used data on 170,628 recipients autologous and allogeneic reported Center for International Blood Marrow Transplant Research from 1968 2009 estimate current future survivors United States. Stacked cohort simulation models were States make projections by year 2030. There 108,900 (range, 100,500...
LBA4 Background: The addition of BV to initial chemotherapy improves overall survival (OS) in adults and PFS pediatric patients (pts) with AS HL. However, frontline adds toxicity, most pts receive radiation therapy (RT), 7-20% still develop relapsed/refractory (RR) PD-1 pathway is central the pathogenesis HL blockade effective RR adult cooperative groups National Clinical Trials Network (NCTN) conducted randomized, phase 3 S1826 trial evaluate N-AVD vs BV-AVD newly diagnosed Methods:...
In adults with advanced-stage Hodgkin's lymphoma, the CD30-directed antibody–drug conjugate brentuximab vedotin combined multiagent chemotherapy has been shown to have greater efficacy, but also more toxic effects, than alone. The efficacy of this targeted therapy approach in children and adolescents lymphoma is unclear.
BackgroundIncorporating brentuximab vedotin into the treatment of advanced-stage classic Hodgkin's lymphoma improves outcomes in adult and pediatric patients. However, increases toxic effects adults, more than half patients who receive drug undergo consolidative radiation, relapse remains a challenge. Programmed death 1 blockade is effective lymphoma, including preliminary studies involving previously untreated patients.MethodsWe conducted phase 3, multicenter, open-label, randomized trial...
The factor structure of the Brief Symptom Inventory--18 (BSI-18; L. R. Derogatis, 2000) was investigated in a sample adult survivors childhood cancer enrolled Childhood Cancer Survivor Study (CCSS; N = 8,945). An exploratory analysis with randomly chosen subsample supported 3-factor closely corresponding to 3 BSI-18 subscales: Depression, Anxiety, and Somatization. Confirmatory structural equation modeling validated this 3-dimensional separate subsample, though an alternative 4-factor model...
Historically, health-related quality of life (HRQL) assessment in pediatrics, including the few validated instruments pediatric oncology, has been based on proxy reporting, relying primarily parental assessment. Children have deemed incapable providing consistent and reliable information about their level functioning or state well-being. Previous studies hampered by either limited poor correlation among reporters, i.e., teachers, parents physicians, comparisons to disease severity. Simply...
Autologous hematopoietic cell transplantation (auto-HCT) is performed to treat relapsed and recurrent malignant disorders as part of initial therapy for selected malignancies. This study evaluated changes in use, techniques, survival a population-based cohort 68,404 patients who underwent first auto-HCT US or Canadian center between 1994 2005 were reported the Center International Blood Marrow Transplant Research (CIBMTR). The mean annual number auto-HCTs was highest during 1996-1999 (6948),...
BACKGROUND Patient navigation may reduce cancer disparities associated with socioeconomic status (SES) and household factors. This study examined whether these factors were delays in diagnostic resolution among patients screening abnormalities patient ameliorated delays. METHODS analyzed data from 5 of 10 centers the National Cancer Institute's Navigation Research Program, which collected SES on employment, income, education, housing, marital status, composition. The primary outcome was time...
Background A high prevalence of obesity has been increasingly recognized in survivors pediatric ALL. However, longitudinal patterns weight change during and after treatment, associated factors, are less well elucidated. Procedure In a retrospective cohort 83 patients with ALL diagnosed between 1985 2010, we examined body mass index (BMI) status at several key time points: diagnosis; end induction; consolidation; every 6 months maintenance; yearly for up to 5 years post‐treatment. Results At...
Rationale: Expansion of chronic ventilation options and shared decision-making have contributed to an increasing population technology-dependent children. One particularly vulnerable group is children with tracheostomy who depend on technology for basic respiratory functions. Chronic critical care now provided in the homecare setting implications family caregivers.Objectives: This study explores experience caregivers young adults a during transition from hospital home care. We sought...
PURPOSE Health-related social needs (HRSNs) are associated with adverse cancer health outcomes. We assessed the processes for screening and responding to both HRSNs financial distress described methods used across National Cancer Institute Community Oncology Research Program (NCORP) practices. METHODS The NCORP 2022 Landscape Assessment survey focused on services screen respond within a national network of community oncology calculated proportions practices that screened responded distress,...
PURPOSE: Although the number of autologous and allogeneic stem-cell transplantations (SCT) is increasing, relatively little information about recovery after transplantation available. Quantitative appropriate for patient counseling difficult to discern from literature. We sought suggest reasonable expectations symptoms SCT hematologic malignancies other disorders using following measures: (1) objective measures health status, such as frequency clinic visits, need rehospitalization,...
Purpose To evaluate the feasibility of risk stratification children with cancer and febrile neutropenia using a simple set criteria from data available to clinician at time patient's presentation. Patients Methods This study is retrospective cohort all admitted single institution fever (defined as an absolute neutrophil count <500 cells/mm 3 ) in 1-year period. were defined priori low if they outpatients presentation neutropenia, had anticipated duration less than 7 days, no significant...
Bone marrow transplant patients have impaired responses to pure polysaccharide (PS) vaccines and are at an increased risk for disease caused by PS encapsulated pathogens such as Haemophilus influenzae type B (HIB) Streptococcus pneumoniae. We immunized 35 BMT (21 allogeneic 14 autologous) ages 2–45 years with pneumococcal (Pnu-imune 23), HIB-conjugate (HibTITER), tetanus toxoid vaccines. Patients were assigned receive either 12 24 months after transplantation or only. Only 19% of all...