A5054037976- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Acute Lymphoblastic Leukemia research
- Polyomavirus and related diseases
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Renal Transplantation Outcomes and Treatments
- Lymphoma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Cytomegalovirus and herpesvirus research
- Transplantation: Methods and Outcomes
- Mesenchymal stem cell research
- CAR-T cell therapy research
- Immunodeficiency and Autoimmune Disorders
- Hemoglobinopathies and Related Disorders
- Multiple Myeloma Research and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Monoclonal and Polyclonal Antibodies Research
- Virus-based gene therapy research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Viral-associated cancers and disorders
- Neutropenia and Cancer Infections
Harvard University
2016-2025
Dana-Farber Cancer Institute
2016-2025
Brigham and Women's Hospital
2013-2024
Dana-Farber Brigham Cancer Center
2011-2024
Infinity Pharmaceuticals (United States)
2011-2017
Bristol-Myers Squibb (Switzerland)
2017
Seagen (Canada)
2017
Bristol-Myers Squibb (United States)
2017
MSD K.K. (Japan)
2017
Pfizer (United Kingdom)
2017
PURPOSE Recipients of allogeneic bone marrow transplants (BMTs) who have relapsed may attain complete remissions when treated with transfusions leukocytes obtained from the original donor. We performed a retrospective study to characterize better this new treatment modality. PATIENTS AND METHODS surveyed 25 North American BMT programs regarding their use donor leukocyte infusions (DLI). Detailed forms were used gather data BMT, relapse, DLI, response complications and long-term follow-up...
Dysfunction of regulatory T (Treg) cells has been detected in diverse inflammatory disorders, including chronic graft-versus-host disease (GVHD). Interleukin-2 is critical for Treg cell growth, survival, and activity. We hypothesized that low-dose interleukin-2 could preferentially enhance vivo suppress clinical manifestations GVHD.
▪ Objective: To determine whether glutamine-supplemented parenteral nutrition improves nitrogen retention and reduces hospital morbidity compared with standard after bone marrow transplantation. Design: Double-blind, randomized, controlled clinical trial. Setting: University teaching hospital. Patients: Forty-five adults receiving allogeneic transplants for hematologic malignancies. Intervention: Parenteral was initiated the day transplantation (day 1). The experimental solution supplemented...
Genetic mutations drive the pathogenesis of myelodysplastic syndrome (MDS) and are closely associated with clinical phenotype. Therefore, genetic may predict outcomes after allogeneic hematopoietic stem-cell transplantation.We performed targeted mutational analysis on samples obtained before transplantation from 1514 patients MDS who were enrolled in Center for International Blood Marrow Transplant Research Repository between 2005 2014. We evaluated association outcomes, including overall...
The behavior of intact rats and with chronic gastric fistulas was observed scored during a 60-min test period when they were offered liquid diet after 17 hr food deprivation. Intact closed displayed specific behavioral sequence at the end each meal: They stopped eating, engaged in grooming exploration for short time, then rested or slept. Thus, fixed characterizes satiety rat. Although fixed, cessation feeding not sufficient condition appearance rest sequence: Quinine adulteration sham but...
Loss of donor-mediated immune antitumor activity after allogeneic hematopoietic stem-cell transplantation (HSCT) permits relapse hematologic cancers. We hypothesized that checkpoint blockade established by targeting cytotoxic T-lymphocyte–associated protein 4 with ipilimumab could restore reactivity through a graft-versus-tumor effect.
The ability of allogeneic bone marrow transplantation to cure chronic myeloid leukemia (CML) is due both the conditioning regimen and antileukemic effects lymphocytes in grafted marrow. We studied interferon alfa-2b infusions mononuclear cells from donor induce a graft-versus-leukemia reaction patients with CML relapse after transplantation.
Regulatory T cell homeostasis is restored in patients with chronic graft-versus-host disease who receive low-dose interleukin-2 therapy.
Purpose Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related condition characterized by somatic mutations in the blood otherwise healthy adults. We hypothesized that patients undergoing autologous stem-cell transplantation (ASCT) for lymphoma, CHIP at time ASCT would be associated with increased risk myelodysplastic syndrome and acute myeloid leukemia, collectively termed therapy-related neoplasm (TMN), other adverse outcomes. Methods performed whole-exome sequencing on...